Concerted Inhibition and Its Reversal by End Products of Aspartate kinase in Brevibacterium flavum*

Pathway and Regulation of Lysine Biosynthesis inBrevibacterium lactofermentum

“…it has been reported that the aspartokinase was sensitive to the feedback inhibition in the simultaneous presence of Lthreonine and L-lysine, and this enzyme was the main regulatory site in the lysine biosynthesis. 8 ) In order to examine the properties of the aspartokinase of B. lactofermentum, the enzyme was partially purified.…”

Regulation of aspartokinase in Lactobacillus plantarum

“…Reports have shown that there is no universal mechanism of regulation for aspartokinases produced by different micro-organisms. Overproduction of lysine in bacteria results from an altered feedback control of aspartokinase (Shiio and Miyajima 1969).…”

l-Lysine Production by S-(2-Aminoethyl)l-Cysteine and α-Amino-β-hydroxyvareIic Acid Resistant Mutants ofBrevibacterium lactofermentum

“…I} Shiio et al,9) reported that the inhibition by L-Iysine was competitive to aspartate, while the inhibition by L-threonine was partially competitive to both aspartate and ATP in B.flavum. When L-threonine had been bound to the enzyme or the enzyme-ATP complex, L-Iysine showed approximately 17 and 100 times higher affinity to these enzyme complexes, respectively.…”