Concerted functions of<i>Streptococcus gordonii</i>surface proteins PadA and Hsa mediate activation of human platelets and interactions with extracellular matrix

Haworth, Jennifer; Jenkinson, Howard F.; Petersen, H; Back, Catherine R.; Brittan, Jane L.; Kerrigan, Steven W.; Nobbs, Angela H.

doi:10.1111/cmi.12667

Cited by 14 publications

(10 citation statements)

References 61 publications

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“…The unique character of having these proteins are that they may cause thrombus as well as being self-protected by biofilm. This might explain the virulence of the bacteria leading to IE even in immunocompetent patient 8. Our patient is an immunocompetent patient who developed IE which later complicated with devastating condition.…”

Section: Discussionmentioning

confidence: 81%

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Intracranial bleeding (ICB) as a catastrophic complication of Streptococcus gordonii infective endocarditis (IE) in an immunocompetent patient

et al. 2018

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We present an interesting case of late-onset intracranial bleeding (ICB) as a complication of causing infective endocarditis. A previously healthy young woman was diagnosed with infective endocarditis. While she was already on treatment for 2 weeks, she had developed seizures with a localising neurological sign. An urgent non-contrasted CT brain showed massive left frontoparietal intraparenchymal bleeding. Although CT angiogram showed no evidence of active bleeding or contrast blush, massive ICB secondary to vascular complication of infective endocarditis was very likely. An urgent decompressive craniectomy with clot evacuation was done immediately to release the mass effect. She completed total 6 weeks of antibiotics and had postoperative uneventful hospital stay despite having a permanent global aphasia as a sequel of the ICB.

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Section: Discussionmentioning

confidence: 81%

“…Recent study revealed that S. gordonii interact with platelets to form clot 8. An interesting pathomechanism of S. gordonii is that it can mimic a damaged endothelium.…”

Section: Discussionmentioning

confidence: 99%

Intracranial bleeding (ICB) as a catastrophic complication of Streptococcus gordonii infective endocarditis (IE) in an immunocompetent patient

et al. 2018

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“…Rather, what is expressed and present during colonization of the oral cavity may be sufficient to colonize the endocardium. In support of this, surface adhesins Hsa, PadA and SspA/B from S. gordonii have been implicated in IE through their engagement with platelets, yet also contribute to the capacity for S. gordonii to bind salivary pellicle and other oral microbes (134)(135)(136)(137).…”

Section: S Sanguinis As An Etiological Agent Of Extraoral Diseasesmentioning

confidence: 89%

Genetics ofsanguinis-Group Streptococci in Health and Disease

Nobbs

Kreth

2019

Microbiol Spectr

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With the application of increasingly advanced “omics” technologies to the study of our resident oral microbiota, the presence of a defined, health-associated microbial community has been recognized. Within this community, sanguinis -group streptococci, comprising the closely related Streptococcus sanguinis and Streptococcus gordonii , together with Streptococcus parasanguinis , often predominate. Their ubiquitous and abundant nature reflects the evolution of these bacteria as highly effective colonizers of the oral cavity. Through interactions with host tissues and other microbes, and the capacity to readily adapt to prevailing environmental conditions, sanguinis -group streptococci are able to shape accretion of the oral plaque biofilm and promote development of a microbial community that exists in harmony with its host. Nonetheless, upon gaining access to the blood stream, those very same colonization capabilities can confer upon sanguinis -group streptococci the ability to promote systemic disease. This article focuses on the role of sanguinis -group streptococci as the commensurate commensals, highlighting those aspects of their biology that enable the coordination of health-associated biofilm development. This includes the molecular mechanisms, both synergistic and antagonistic, that underpin adhesion to substrata, intercellular communication, and polymicrobial community formation. As our knowledge of these processes advances, so will the opportunities to exploit this understanding for future development of novel strategies to control oral and extraoral disease.

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“…S. gordonii, also amongst the common pathogens isolated from subjects with infective endocarditis, is ubiquitous within the human oral cavity. Two of their cell surface proteins mediate adherence and activation of platelets, binding to cellular fibronectin and vitronectin, and also promote formation of biofilms [ 141 , 142 ]. Platelet aggregation was promoted by biofilms of oral bacteria in vitro, including P. gingivalis [ 142 , 143 , 144 ].…”

Section: Main Textmentioning

confidence: 99%

“…One is a systemic dissemination from the ulcerated gingival pockets into the bloodstream that allows P. gingivalis or F. nucleatum access to the colon. In this context a biofilm-platelet complex make sense [ 133 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 ]. These species have been implicated in other diseases such as adverse pregnancy outcomes including stillbirth, liver cirrhosis, and rheumatoid arthritis [151] .…”

Section: Main Textmentioning

confidence: 99%

Oral hygiene might prevent cancer

Cordero

Varela-Calviño

2018

Heliyon

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Many evidences support that species from the Human Oral Microbiome Database such as Fusobacterium nucleatum or Bacteroides, linked previously to periodontitis and appendicitis, play a role in colorectal cancer (CRC), including metastasis. These typically oral species are invasive anaerobes that form biofilms in their virulent state.Aspirin (a NSAID) has been recently included into routine CRC prevention rationale. NSAIDs can prevent the growth of neoplastic lesions by inhibiting COX enzymes and another set of recently identified COX-independent targets, which include the WNT, AMPK and MTOR signaling pathways, the crosstalk between nucleoli and NF-κB transcriptional activity in apoptosis, and the biochemistry of platelets. These are signaling pathways related to tumor-promoting inflammation. In this process, pathogens or simple deregulation of the microbiota play an important role in CRC. Aspirin and other NSAIDs are efficient inhibitors of biofilm formation and able to control periodontitis development preventing inflammation related to the microbiota of the gingival tissue, so its seems plausible to include this pathway in the mechanisms that aspirin uses to prevent CRC.We propose arguments suggesting that current oral hygiene methods and other future developments against periodontitis might prevent CRC and probably other cancers, alone or in combination with other options; and that the multidisciplinary studies needed to prove this hypothesis might be relevant for cancer prevention.

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Concerted functions ofStreptococcus gordoniisurface proteins PadA and Hsa mediate activation of human platelets and interactions with extracellular matrix

Cited by 14 publications

References 61 publications

Intracranial bleeding (ICB) as a catastrophic complication of Streptococcus gordonii infective endocarditis (IE) in an immunocompetent patient

Intracranial bleeding (ICB) as a catastrophic complication of Streptococcus gordonii infective endocarditis (IE) in an immunocompetent patient

Genetics ofsanguinis-Group Streptococci in Health and Disease

Oral hygiene might prevent cancer

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