Concerns about 99mTc-labelled ciprofloxacin for infection detection

Overview of Host Defense Peptides and Their Applications for Plastic and Reconstructive Surgeons

“…Host defense peptides exert their multiple actions through a myriad of mechanisms. In general, these mechanisms must be specific for infectious agents and malignant cells while simultaneously sparing host tissues;importantly, HDPs have been observed to specifically differentiate infectious processes from sterile inflammation 30.…”

Preliminary evaluation of technetium-99m-labeled ceftriaxone: infection imaging agent for the clinical diagnosis of orthopedic infection

“…However, bottlenecks in the use of the kit such as the need for filtration during reconstitution caused additional radiation burden and led to the loss of radioactivity. [15][16][17] Looking at the need for a better infection imaging formulation with higher specificity towards bacteria, we labeled ceftriaxone (CRO) (Figure 1a), a third-generation…”

The many roads to infection imaging

“…On the contrary, most pre-clinical studies have shown poor specificity of technetium-labelled ciprofloxacin for bacterial infections [2-7] and vivid discussions related to this topic took place [8-10, 17]. One of the most tested radiolabelled ciprofloxacin is Infecton® (Draximage, Quebec, Canada).…”