Concerning the Mechanism of Trigeminal Neuralgia and Hemifacial Spasm

Wj, Gardner

doi:10.3171/jns.1962.19.11.0947

Cited by 458 publications

(167 citation statements)

References 49 publications

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“…Janneta and his colleagues observed neurogenic hypertension in surgical cases and suggested that pulsatile compression of the lateral medulla oblongata may cause arterial hypertension. 4 The results of clinical studies 11,12 and a microanatomical study 13 support this concept. Kleineberg et al 5 also found evidence suggesting that essential hypertension is related to neurovascular compression in an angiographic study.…”

Section: Discussionmentioning

confidence: 88%

“…6,7 Clinical studies using MRT have suggested that the neurovascular compression may cause hypertension has been reported. 8,9,13 The frequency of neurovascular compression of the RVLM has been found to be high in German, 9 Italian 14 and Japanese 8,9 patients with essential hypertension. These observations suggest that neurovascular compression of the RVLM may play an important role in the pathogenesis of essential hypertension.…”

Section: Discussionmentioning

confidence: 97%

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The potent role of increased sympathetic tone in pathogenesis of essential hypertension with neurovascular compression

et al. 2000

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Objective: To study the role of increased sympathetic tone in pathogenesis of hypertension in patients with essential hypertension with neurovascular compression. Methods: Twenty-three patients with essential hypertension, 13 patients with secondary hypertension, and 46 normotensive subjects were investigated. Neurovascular compression was evaluated by MRT. The power spectral components of heart rate variability as indices of autonomic nerve tone were determined to investigate the possibility that sympathetic tone mediates the neurovascular compression-induced increase in blood pressure. Results: Neurovascular compression of the rostral ventrolateral medulla (RVLM) was observed in 70% of essential hypertension group, none of secondary hyperension group and 16% of normotensive group (P Ͻ 0.001). The age-adjusted low-frequency power spectral density (A-PSD) (0.04 to 0.15 Hz), which is an index of

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 97%

The potent role of increased sympathetic tone in pathogenesis of essential hypertension with neurovascular compression

et al. 2000

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“…3 Campbell and Keedy 2 and Gardner 4 had reported that vascular compression of the facial nerve was the potential mechanism of HFS. However, they never mentioned the site of compression to the nerve.…”

Section: Discussionmentioning

confidence: 99%

Microvascular decompression for atypical hemifacial spasm: lessons learned from a retrospective study of 12 cases

Liu¹,

Yue²,

Fang

et al. 2016

JNS

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obJective Typical hemifacial spasm (HFS) commonly initiates from the orbicularis oculi muscle to the orbicularis oris muscle. Atypical HFS (AHFS) is different from typical HFS, in which the spasm of muscular orbicularis oris is the primary presenting symptom. The objective of this study was to analyze the sites of compression and the effectiveness of microvascular decompression (MVD) for AHFS. Methods The authors retrospectively analyzed the clinical data for 12 consecutive patients who underwent MVD for AHFS between July 2008 and July 2013. results Postoperatively, complete remission of facial spasm was found in 10 of the 12 patients, which gradually disappeared after 2 months in 2 patients. No recurrence of spasm was observed during follow-up. Immediate postoperative facial paralysis accompanied by hearing loss occurred in 1 patient and temporary hearing loss with tinnitus in 2. All 3 patients with complications had gradual improvement during the follow-up period. coNclusioNs The authors conclude that most cases of AHFS were caused by neurovascular compression on the posterior/rostral side of the facial nerve distal to the root entry zones. MVD is a safe treatment for AHFS, but the incidence of postoperative complications, such as facial paralysis and decrease in hearing, remains high.

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“…Most cases of TN are elicited by vascular compression at the REZ of the trigeminal nerve. 3,7,9) In our series of 684 patients with TN treated surgically between 1975 and 2005, approximately 90% of cases of TN were elicited by compression from a conflicting artery. In the remaining 10% of cases, TN apparently occurred without any vascular involvement.…”

Section: Discussionmentioning

confidence: 99%

Intrinsic Arteriovenous Malformation Embedded in the Trigeminal Nerve of a Patient With Trigeminal Neuralgia -Case Report-

Sumioka

Kondo

Tanabe

et al. 2011

Neurol. Med. Chir.(Tokyo)

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A 66-year-old man presented with typical right trigeminal neuralgia. Neuroimaging showed a small arteriovenous malformation (AVM) in the right cerebellopontine angle. Suboccipital craniotomy verified that the AVM was almost completely embedded in the root entry zone of the trigeminal nerve and the nerve axis was tilted infero-posteriorly. The patient obtained complete pain relief without sequelae after surgery by transposition of the superior cerebellar artery and correction of the tilted nerve axis. The nidus of the unresected AVM was obliterated by gamma knife radiosurgery.

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Concerning the Mechanism of Trigeminal Neuralgia and Hemifacial Spasm

Cited by 458 publications

References 49 publications

The potent role of increased sympathetic tone in pathogenesis of essential hypertension with neurovascular compression

The potent role of increased sympathetic tone in pathogenesis of essential hypertension with neurovascular compression

Microvascular decompression for atypical hemifacial spasm: lessons learned from a retrospective study of 12 cases

Intrinsic Arteriovenous Malformation Embedded in the Trigeminal Nerve of a Patient With Trigeminal Neuralgia -Case Report-

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