Conceptualization of depression in Parkinson?s disease

Looi, Jeffrey Cl; Matias, May; Ruzich, Michelle J

doi:10.2147/nedt.1.2.135.61051

Cited by 3 publications

(3 citation statements)

References 59 publications

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“…Despite the widespread adoption of Mask R-CNN, we found this algorithm did not perform exceptionally well in our study. Our results suggest that this is due to dense cell fields with overlapping bounding boxes, a feature known to corrupt the training process and produce poor network outputs for Mask R-CNN 44 . By contrast, the StarDist network makes robust predictions, but it fails to assemble accurate cell masks because the cells in our dataset are not well approximated by star-convex polygons 26 .…”

Section: Discussionmentioning

confidence: 95%

Omnipose: a high-precision morphology-independent solution for bacterial cell segmentation

Cutler

Stringer

Wiggins

et al. 2021

Preprint

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Advances in microscopy hold great promise for allowing quantitative and precise readouts of morphological and molecular phenomena at the single cell level in bacteria. However, the potential of this approach is ultimately limited by the availability of methods to perform unbiased cell segmentation, defined as the ability to faithfully identify cells independent of their morphology or optical characteristics. In this study, we present a new algorithm, Omnipose, which accurately segments samples that present significant challenges to current algorithms, including mixed bacterial cultures, antibiotic-treated cells, and cells of extended or branched morphology. We show that Omnipose achieves generality and performance beyond leading algorithms and its predecessor, Cellpose, by virtue of unique neural network outputs such as the gradient of the distance field. Finally, we demonstrate the utility of Omnipose in the characterization of extreme morphological phenotypes that arise during interbacterial antagonism and on the segmentation of non-bacterial objects. Our results distinguish Omnipose as a uniquely powerful tool for answering diverse questions in bacterial cell biology.

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Section: Discussionmentioning

confidence: 95%

Omnipose: a high-precision morphology-independent solution for bacterial cell segmentation

Cutler

Stringer

Wiggins

et al. 2021

Preprint

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“…It is possible then that depression among those with or at risk of PD may be represented by outcomes other than major depression, such as depressed mood. Consideration to a broader interpretation of depression among those with PD has been suggested [23]. …”

Section: Discussionmentioning

confidence: 99%

“…In a study of an Irish family kindred, Khan et al observed dopaminergic dysfunction in the caudate and putamen measured by [ 18 F]-dopa among four subjects with heterozygous parkin mutations, all of whom were asymptomatic [27]. Degeneration of dopaminergic fibers, especially those arising from the ventral tegmental area, has been suggested to be involved in depression [23]. Parkin knockout mice with the exon 7 deletion exhibit cell loss in the locus coeruleus [28] where such loss is postulated to be developmental rather than age-related.…”

Section: Discussionmentioning

confidence: 99%

The relation between depression and parkin genotype: The CORE-PD study

Srivastava

Tang

Mejia‐Santana

et al. 2011

Parkinsonism & Related Disorders

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Background Mutations in parkin are a known genetic risk factor for early-onset Parkinson’s disease (EOPD) but their role in non-motor manifestations is not well established. Genetic factors for depression are similarly not well characterized. We investigate the role of parkin mutations in depression among those with EOPD and their relatives. Methods We collected psychiatric information using the Patient Health Questionnaire and Beck Depression Inventory II on 328 genotyped individuals including 88 probands with early onset PD (41 with parkin mutations, 47 without) and 240 first and second degree relatives without PD. Results Genotype was not associated with depression risk among probands. Among unaffected relatives of EOPD cases, only compound heterozygotes (n=4), and not heterozygotes, had significantly increased risk of depressed mood (OR=14.1; 95% CI 1.2–163.4), moderate to severe depression (OR=17.8; 95% CI 1.0–332.0), depression (score ≥15) on the Beck Depression Inventory II (BDI-II) (OR=51.9; 95% CI 4.1–657.4), and BDI-II total depression score (β=8.4; 95% CI 2.4–11.3) compared to those without parkin mutations. Conclusions Relatives of EOPD cases with compound heterozygous mutations and without diagnosed PD may have a higher risk of depression compared to relatives without parkin mutations. These findings support evidence of a genetic contribution to depression and may extend the phenotypic spectrum of parkin mutations to include non-motor manifestations that precede the development of PD.

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Depression and Parkinson's disease: a Chicken-Egg story

Chakraborty¹,

Diwan

2022

AIMSN

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<abstract> <p>Parkinson's disease (PD) is a neurodegenerative disease, however, besides the motor symptoms, such as rest tremor, hypokinesia, postural instability and rigidity, PD patients have also non-motor symptoms, namely neuropsychiatric disorders. Apart from the required motor symptoms, psychopathological symptoms are very common and include mood disorders, anxiety disorders, hallucinations, psychosis, cognitive deterioration and dementia. The underlying pathophysiological process in PD is mainly due to the loss of dopaminergic neural cells and thereby causes the shortage of nigrostriatal dopamine content in them. In addition, it may involve other neurotransmitter systems such as the noradrenergic, serotonergic, cholinergic and noradrenergic systems as well. Depression can result from any unhealthy conditions making the diagnosis a challenging task. The manifestation of depression associated with or without PD is inadequate. The co-occurrence of depression and PD often leads to the conceptual discussion on whether depressive symptoms appear before or after PD develops. This paper will discuss the conceptual mechanism of PD and depression. Keep in mind both conditions belong to two separate entities but share some similar aspects in their pathophysiology.</p> </abstract>

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Conceptualization of depression in Parkinson?s disease

Cited by 3 publications

References 59 publications

Omnipose: a high-precision morphology-independent solution for bacterial cell segmentation

Omnipose: a high-precision morphology-independent solution for bacterial cell segmentation

The relation between depression and parkin genotype: The CORE-PD study

Depression and Parkinson's disease: a Chicken-Egg story

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