This chapter seeks to explore some aspects of the complex relations existing between learning and work. It investigates how individuals engaging in production tasks may encounter learning opportunities in the workplace and how these opportunities may best be recognised, understood and reproduced for training purposes. These considerations have become of particular interest as increasingly aspects of professional practice are being connected to educational purposes. These connections certainly have a long tradition and history, particularly in western apprenticeship programmes, where the workplace is conceptualised as a legitimate and rich context for the development of professional competences (Fuller and Unwin 2013;Gonon 2005). These connections between learning and work have also been under particular scrutiny in the context of tertiary education, where an increasing number of vocational training programmes are engaging students with practicum experiences. These experiences, which complement formal teaching periods, occur in the circumstances of practice and are subject to complex forms of learning outcomes, which are highly dependent on individual and contextual factors (Akkerman and Bakker 2012;Billett et al. 2013;Tynjälä 2008). Hence, vocational training programmes appear as highly concerned by the conditions under which learning arises in and through professional practice itself. These concerns have certainly been extensively addressed in Anglophone research traditions, but they have also attracted a lot of attention in the Francophone research fields related to training and work.More specifically, the chapter focuses on the role and place of guidance and mentoring in learning as it may occur in the circumstances of work. The recent literature in the field of workplace learning has stressed the importance of guidance in the process of learning in and from practice (Billett 2001a, b;Fuller and Unwin