Conceptual model of adding antibiotics to dialysate fluid during renal replacement therapy

Abstract

Studies have shown significant variability in antibiotic trough concentrations in critically ill patients receiving renal replacement therapy (RRT). The purpose of this study was to assess whether adding beta-lactam antibiotics to dialysate solution can maintain stable antibiotic concentrations during RRT in experimental conditions. A single compartment model reflecting the patient was constructed and connected to the RRT machine. Dialysate fluid was prepared in three different concentrations of meropenem (0 mg/L; 16 mg/L; 64 mg/L). For each dialysate concentration various combinations of dialysate and blood flow rates were tested by taking different samples. Meropenem concentration in all samples was calculated using spectrophotometry method. Constructed experimental model results suggest that decrease in blood meropenem concentration can be up to 35.6%. Moreover, experimental data showed that antibiotic loss during RRT can be minimized and stable plasma antibiotic concentration can be achieved with the use of a 16 mg/L Meropenem dialysate solution. Furthermore, increasing meropenem concentration up to 64 mg/L is associated with an increase antibiotic concentration up to 18.7–78.8%. Administration of antibiotics to dialysate solutions may be an effective method of ensuring a constant concentration of antibiotics in the blood of critically ill patients receiving RRT.

Dialysis as a Novel Adjuvant Treatment for Malignant Cancers

“…The loss of drugs during dialysis treatment is well known in both chronic dialysis and acute dialysis [ 56 , 57 ]. Possibly, a cytotoxic agent may be added to the dialysis fluid as suggested for antibiotics during CRRT in sepsis—either to compensate for the loss of the drug this way or to fully administer the cytotoxic agent in the dialysis fluid, thereby adding the benefit of controlling the levels of the agent in the blood throughout the CancerDialysis treatment [ 56 , 58 ]. Nevertheless, the best opportunity for applying CancerDialysis could be closely in time after the TCT.…”