Concepts of Stroke Before and After Virchow

Abstract

CoNTRARY to chronology, or the logic of first things first-but to nobody's surprisethe latest ideas about strokes are readily accessible, while much effort is needed to bridge the gap lying in the direction of their past.' Yet the essential observations go far back and are much hidden by contemporary, often ephemeral growth. We hardly get to see the wood for the leaves. Where are the stems that keep our knowledge green? 'Stroke' for us-unlike coup in French or Schlag in German-acquires its morbid meaning simply from the context. 'He had a stroke' needs no elaboration. Former ages, taking no semantic chances, would not let the word go unattended by a qualification such as 'paralytic' or 'apoplectic', used indiscriminately. In the Oxford English Dictionary the first synonym for the 'stroke of the palsy' is given as 'stroke of God's hands', 1599. Today, apoplexy sounds a little quaint. It is the classical striking off or down. The Latin equivalents morbus attonitus and sideratio-literally 'being thunderstruck'-suggest both a celestial force and an affliction of the mind.2 Embolism and thrombosis are usually traced, with good reason, to Virchow and the mid-nineteenth century. Thrombus, since antiquity, has been a coagulum, clot, or curd in blood and milk. In surgery it has done duty for the seal that is on a vessel punctured or severed. Embolus, long before Virchow, was in use for a variety of connotations different from his and ours. The odd, extra day that calendar-makers had to intercalate was an embolus. In surgeons' terminology it stood for throwing in of the humeral or femoral head to reduce a dislocation. In the seventeenth century the plunger of a syringe was an embole.' We do not say 'apoplegia' or 'paraplexy', although we might. In the Greek and English language, chance or euphony have fixed these near homonyms and synonyms to be the way they are. Paraplegia or paraplexia, for Aretaeus, was but a minor variant, a 'para' or 'near' apoplexy. It is the incomplete or circumscribed loss of function, the paresis 'of a part only', 'the letting go of touch and motion in either a hand or a leg'. Paralysis was the more technical term, for it was defined by Aretaeus as a pdresis-evidently the non-technical expression. Paralysis or paresis denotes the loss of function that affects motion-loss, he adds, of 'energeia': energy perhaps, but not quite; 'the thing inherent in work'.' All the terms: apoplexy, paraplegia, paresis, paralysis, here refer to the same sort of thing, or to degrees of it. 'Apoplexy is a paralysis', Aretaeus says, 'but a paralysis 1 Since this was written the student has been enabled to consult L. C. McHenry, Garrison's History of Neurology, Springfield, Ill., Thomas, 1969, pp. 370-87. 'E. Clarke, 'Apoplexy in the Hippocratic writings', Bull. Hist. Med., 1963, 37, 301-14. 8 References to old English usage from the Oxford English Dictionary. 'Aretaeus, the Cappadocean: The Extant Works, ed. and trans.

Henry Duret (1849-1921): A Surgeon and Forgotten Neurologist

“…In Germany in 1872, Julius Cohnheim (1839-1884), student of Rudolf Virchow (1821-1902), structured and named the modern concepts of embolic cerebral infarction, terminal arteries, and anastomoses (backup circulatory routes). However, none of these authors associate specific supply arteries with precise locations [14,15] .…”

“…According to Aitken, he did not find Duret's artères lenticulo-opiques and therefore claimed that Heubner's de- [20][21][22][23] . Despite the beginning of a controversy that has continued from Duret's death until now, these two publications earned Duret the Prix Ernest Godard (1826-1862), discerned by the Biological Society of Paris in 1874 [15,24,25] ( fig. 3 ).…”

Nihilism and stroke therapy.

“…This view is reflected best by the definition of stroke in the 1599 Oxford English Dictionary as a "stroke of God's hands." 2 The logical deduction was that if the disease were caused by divine intervention, no human intervention such as drug therapy could possibly alter the outcome. Often, stroke has been referred to as a "cerebrovasoilar accident," a term that supports the concept of stroke as a random, unpreventable catastrophe.…”

Pharmacoeconomic analysis of treatment of patients with severe and moderate ischemic stroke (NIHSS score > 12)

“…About 16 million cases of stroke are registered in the world annually, including 5,7 million with lethal outcome which equals 10% of total mortality in the world [3][4][5][6]. It should be especially noted that sever and moderate ISs take about 40-65% and this category of patients is characterized with high mortality [7][8][9][10].…”

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Abstract: this study includes pharmacoeconomic analysis of treatment of patients with severe and moderate ischemic stroke (NIHSS score > 12

IntroductionIschemic stroke (IS) is a clinical syndrome manifesting as an acute disorder of local cerebral functions which lasts for more than 24 hours or causes death; it can be caused either by insufficiency of blood supply in certain brain area due to cerebral blood flow reduction, thrombosis or embolism connected with vascular, cardiac or blood diseases [1,2].About 16 million cases of stroke are registered in the world annually, including 5,7 million with lethal outcome which equals 10% of total mortality in the world [3][4][5][6]. It should be especially noted that sever and moderate ISs take about 40-65% and this category of patients is characterized with high mortality [7][8][9][10].

Today severe and moderate IS are one of the main causes of people disability.

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