Concepts of Regeneration for Spinal Diseases in 2021

Yurube, Takashi; Han, In Ho; Sakai, Daisuke

doi:10.3390/ijms22168356

Cited by 5 publications

(4 citation statements)

References 15 publications

(15 reference statements)

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“…The latest studies have shown that an estimated 103 million people worldwide are affected by DSD, while in the US, ~600 000 patients with lumbar spinal stenosis undergo operations each year 4 – 6 . For severe DSD, surgical resection and/or fusion are the primary treatment, especially in patients with neurological symptoms 7 – 9 . However, although surgery can effectively alleviate the symptoms of patients in a timely manner, some postoperative adverse events are inevitable.…”

Section: Introductionmentioning

confidence: 99%

Risk factors of epidural hematoma in patients undergoing spinal surgery: a meta-analysis of 29 cohort studies

Luo,

Cao,

Zhao

et al. 2023

International Journal of Surgery

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Objective: The authors conducted this meta-analysis to identify risk factors for spinal epidural haematoma (SEH) among patients following spinal surgery. Methods: The authors systematically searched Pub: Med, Embase, and the Cochrane Library for articles that reported risk factors associated with the development of SEH in patients undergoing spinal surgery from inception to 2 July 2022. The pooled odds ratio (OR) was estimated using a random-effects model for each investigated factor. The evidence of observational studies was classified as high quality (Class I), moderate quality (Class II or III) and low quality (Class IV) based on sample size, Egger’s P value and between-study heterogeneity. In addition, subgroup analyses stratified by study baseline characteristics and leave-one-out sensitivity analyses were performed to explore the potential sources of heterogeneity and the stability of the results. Results: Of 21 791 articles screened, 29 unique cohort studies comprising 150 252 patients were included in the data synthesis. Studies with high-quality evidence showed that older patients (≥60 years) (OR, 1.35; 95% CI, 1.03–1.77) were at higher risk for SEH. Studies with moderate-quality evidence suggested that patients with a BMI greater than or equal to 25 kg/m² (OR, 1.39; 95% CI, 1.10–1.76), hypertension (OR, 1.67; 95% CI, 1.28–2.17), and diabetes (OR, 1.25; 95% CI, 1.01–1.55) and those undergoing revision surgery (OR, 1.92; 95% CI, 1.15–3.25) and multilevel procedures (OR, 5.20; 95% CI, 2.89–9.37) were at higher risk for SEH. Meta-analysis revealed no association between tobacco use, operative time, anticoagulant use or American Society of Anesthesiologists (ASA) classification and SEH. Conclusions: Obvious risk factors for SEH include four patient-related risk factors, including older age, obesity, hypertension and diabetes, and two surgery-related risk factors, including revision surgery and multilevel procedures. These findings, however, must be interpreted with caution because most of these risk factors had small effect sizes. Nonetheless, they may help clinicians identify high-risk patients to improve prognosis.

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Section: Introductionmentioning

confidence: 99%

Risk factors of epidural hematoma in patients undergoing spinal surgery: a meta-analysis of 29 cohort studies

Luo,

Cao,

Zhao

et al. 2023

International Journal of Surgery

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“…Spinal diseases have gradually become one of the primary health concerns, with patients typically undergoing spinal surgery to alleviate pain and improve functionality, but with a high risk of postoperative infection. 26 , 27 The incidence rate of post‐spinal surgery wound infection ranges from 0.2% to 16.1%, averaging 3.1%. 28 Postoperative infections can cause difficult‐to‐heal wounds, prolonged hospital stays, increased mortality and endanger patient safety.…”

Section: Discussionmentioning

confidence: 99%

Effect of wound drainage on the wound infection and healing in patients undergoing spinal surgery: A meta‐analysis

Yang,

Bao,

et al. 2024

International Wound Journal

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A meta‐analysis was conducted to comprehensively evaluate the impact of wound drainage on postoperative wound infection and healing in patients undergoing spinal surgery. Computer searches were performed, from database inception to October 2023, in EMBASE, Google Scholar, Cochrane Library, PubMed, Wanfang and China National Knowledge Infrastructure databases for studies related to the application of wound drainage in spinal surgery. Two researchers independently screened the literature, extracted data and conducted quality assessments. Stata 17.0 software was employed for data analysis. Overall, 11 articles involving 2102 spinal surgery patients were included. The analysis showed that, compared to other treatment methods, the use of wound drainage in spinal surgery patients significantly shortened the wound healing time (standardized mean difference [SMD]: −1.35, 95% confidence intervals [CI]: −1.91 to −0.79, p < 0.001). However, there was no statistical difference in the incidence of wound infection (odds ratio: 1.35, 95% CI: 0.83–2.19, p = 0.226). This study indicates that wound drainage in patients undergoing spinal surgery is effective, can accelerate wound healing and is worth promoting in clinical practice.

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“…Spine-related diseases place a heavy financial and psychological burden on the general population ( 1 ). These diseases include discogenic low back pain (DLBP) ( 2 ), lumbar disc herniation ( 3 ), lumbar disc degeneration ( 4 ), spinal cord injury ( 5 ), ligament injury ( 6 ), and sacroiliac joint disease ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Application of platelet-rich plasma in spinal surgery

et al. 2023

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With the aging of the population and changes in lifestyle, the incidence of spine-related diseases is increasing, which has become a major global public health problem; this results in a huge economic burden on the family and society. Spinal diseases and complications can lead to loss of motor, sensory, and autonomic functions. Therefore, it is necessary to identify effective treatment strategies. Currently, the treatment of spine-related diseases includes conservative, surgical, and minimally invasive interventional therapies. However, these treatment methods have several drawbacks such as drug tolerance and dependence, adjacent spondylosis, secondary surgery, infection, nerve injury, dural rupture, nonunion, and pseudoarthrosis. Further, it is more challenging to promote the regeneration of the interstitial disc and restore its biomechanical properties. Therefore, clinicians urgently need to identify methods that can limit disease progression or cure diseases at the etiological level. Platelet-rich plasma (PRP), a platelet-rich form of plasma extracted from venous blood, is a blood-derived product. Alpha granules contain a large number of cytokines, such as platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), epidermal growth factor, platelet factor 4 (PF-4), insulin-like growth factor-1 (IGF-1), and transforming growth factor-β (TGF-β). These growth factors allow stem cell proliferation and angiogenesis, promote bone regeneration, improve the local microenvironment, and enhance tissue regeneration capacity and functional recovery. This review describes the application of PRP in the treatment of spine-related diseases and discusses the clinical application of PRP in spinal surgery.

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Concepts of Regeneration for Spinal Diseases in 2021

Abstract: It is our pleasure to announce the publication of the Special Issue “Regeneration for Spinal Diseases” in the International Journal of Molecular Sciences (IJMS, ISSN 1422-0067) [...]

Cited by 5 publications

References 15 publications

Risk factors of epidural hematoma in patients undergoing spinal surgery: a meta-analysis of 29 cohort studies

Risk factors of epidural hematoma in patients undergoing spinal surgery: a meta-analysis of 29 cohort studies

Effect of wound drainage on the wound infection and healing in patients undergoing spinal surgery: A meta‐analysis

Application of platelet-rich plasma in spinal surgery

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