Conception of Schizophrenia within the Last Fifty Years and Today [<i>Abridged</i>]

Bleuler, M

doi:10.1177/003591576305601048

Cited by 49 publications

(23 citation statements)

References 4 publications

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“…These observations in late schizophrenics appear to fit the kind of aetiological framework recently obtained by Manfred Bleuler (1963). After looking back on 50 years of research, he wound up as follows:…”

Section: Some Contributions To the Study Of Schizophreniasupporting

confidence: 65%

Key papers in old age psychiatry series Editor: Alistair Burns

Burns¹

1996

Int. J. Geriat. Psychiatry

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Section: Some Contributions To the Study Of Schizophreniasupporting

confidence: 65%

Key papers in old age psychiatry series Editor: Alistair Burns

Burns¹

1996

Int. J. Geriat. Psychiatry

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“…Thus, different aspects of the deprivation experience may produce different quality of responses and underlying neurophysiological abnormality. Alternatively, a diathesis-stress model that postulates some sort of weak organ hypothesis may also be useful in explaining the heterogeneity of response (Bleuler, 1963). In other words, specific phenotype is the result of both early biological vulnerability, genetic or otherwise, combined with the adverse developmental experience of early severe deprivation.…”

Section: Discussionmentioning

confidence: 99%

Incidence of Specific Absolute Neurocognitive Impairment in Globally Intact Children with Histories of Early Severe Deprivation

Behen¹,

Helder²,

Robert³

et al. 2008

Child Neuropsychology

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Postnatal deprivation is associated with neurocognitive delay/dysfunction. Although "catch up" in global cognition following adoption has been reported, this study examined the incidence of specific absolute impairment in adopted children with intact global cognitive functioning. Eighty-five children (38 males, mean age=112.8, SD=30.3 months; range 61−209 months) raised from birth in orphanages underwent comprehensive neuropsychological evaluation. Fifty-four were deemed globally intact (IQ>85). Of those deemed globally intact, 46 percent evidenced absolute impairment in at least one domain of functioning. Duration of stay in the orphanage was directly associated with incidence of impairment and number of domains affected. A substantial proportion of participants evidenced persistent, absolute impairment in one or more domains of neurocognitive function despite integrity of basic intellectual functions.

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“…First applied to schizophrenia [54][55][56][57], the original diathesis-stress model suggested that schizophrenia develops as an interaction between an underlying biologic or genetic substrate (diathesis) and the expression of that substrate under certain stressful conditions. The diathesis-stress model has since been applied to a number of medical illnesses including heart disease [58], asthma [59], diabetes [60], and phenylketonuria [61], as well as to other psychiatric conditions including depressive disorders [62], and eating disorders [63].…”

Section: History Of Diathesis-stress Modelsmentioning

confidence: 99%

Personality and personality disorders in chronic pain

Weisberg

2000

Current Review of Pain

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Personality characteristics and disorders have long been noted in the chronic pain population. Clinicians and researchers alike will attest to the high rates of personality difficulties encountered in these individuals. Historically, it has been found that certain personality styles such as hypochondriasis and hysteria are common in chronic pain suffers. In addition, the prevalence of personality disorders (PDs) is significantly greater in the pain population than in the general population or in medical or psychiatric populations. A diathesis-stress model has been suggested to account for this finding and is discussed in this article, with implications for both treatment and research.

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Conception of Schizophrenia within the Last Fifty Years and Today [Abridged]

Cited by 49 publications

References 4 publications

Key papers in old age psychiatry series Editor: Alistair Burns

Key papers in old age psychiatry series Editor: Alistair Burns

Incidence of Specific Absolute Neurocognitive Impairment in Globally Intact Children with Histories of Early Severe Deprivation

Personality and personality disorders in chronic pain

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