Conception by means of in vitro fertilization is not associated with maternal depressive symptoms during pregnancy or postpartum

Gambadauro, Pietro; Iliadis, Stavros I; Bränn, Emma; Skalkidou, Alkistis

doi:10.1016/j.fertnstert.2017.06.006

Cited by 26 publications

(17 citation statements)

References 43 publications

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“…Despite psychological stress and hormonal stimulation treatments that may expose patients with infertility or subfertility to stress disorders such as depression and anxiety [2], a higher risk of perinatal depressive symptoms has been indicated by one study [17]; our study confirmed in an Italian population the findings of systematic reviews and meta-analyses, showing a lack of correlation between depression and MAR [23,24]. A greater risk of depression in IVF women was also not confirmed by a large Swedish longitudinal study that used the EPDS at the same timepoints as our study [19], and in an Australian study, which found more postpartum adjustment difficulties in women who had gone through several IVF attempts [35,36].…”

Section: Discussionsupporting

confidence: 70%

“…However, an Italian study showed slightly higher anxiety and/or depression rates in both women and partners awaiting IVF/ICSI with respect to the general population, while 18.5% of women and 7.4% of partners who had scored under the threshold at the beginning of the procedures scored above-threshold on anxiety or depression rating scales at the end of the procedures [15]. However, most studies did not find differences in depression between infertile women undergoing treatment for infertility and controls [16][17][18][19][20][21], and one found its prevalence to be reduced in IVF women compared to controls [22]. Results match the conclusions of systematic reviews and meta-analyses, which ruled out a relationship between MAR and postpartum depression [23,24].…”

Section: Introductionmentioning

confidence: 99%

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Perinatal Mood and Anxiety Disorders in Women Undergoing Medically Assisted Reproduction

Koukopoulos

Chiara

Oresti

et al. 2020

Psychiatry International

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Background: Women taking advantage of medically assisted reproduction (MAR) techniques may differ from spontaneously conceiving women (nonMAR) in risk of depression and/or anxiety. We aimed to investigate possible differences between MAR and nonMAR through the use of the Edinburgh Postnatal Depression Scale in a sample of Italian-speaking women at their third trimester of pregnancy. Methods: We administered the Edinburgh Postnatal Depression Scale (EPDS) to two groups of pregnant women, MAR and nonMAR, at the third trimester of pregnancy (T0), one month after delivery (T1), and three months after delivery (T2) from February 2013 to December 2019. EPDS total scores cutoffs were ≥9 for risk of depression, 9–11 mild depression, ≥12 major depression, and the EPDS-3A cluster ≥4 was a proxy for anxiety. Results: Included were 1303 nonMAR women and 92 MAR, an expected disproportion. NonMAR and MAR women did not differ on depression or anxiety at any assessment timepoint. MAR women were older than nonMAR, consumed more alcohol and medical drugs, and displayed more complications during pregnancy. Scoring over the threshold on depression risk was associated with foreign nationality, unemployment, psychiatric history of the patient, family or partner, psychiatric problems in past pregnancies, hyperemesis, premenstrual syndrome (PMS), and stressful life events in the last year at baseline, and, for some of them, at other timepoints. In contrast, MAR past or current was associated with having suprathreshold depression at the first-month postpartum follow-up. Conclusions: Taken together, our data show that women opting for MAR do not differ from spontaneously conceiving women regarding psychiatric outcomes but do differ on some sociodemographic and clinical variables.

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Section: Discussionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Perinatal Mood and Anxiety Disorders in Women Undergoing Medically Assisted Reproduction

Koukopoulos

Chiara

Oresti

et al. 2020

Psychiatry International

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“…A systematic compilation finds out that evidences regarding general anxiety levels of the ART pregnancies are ambiguous (Gourounti 2016). A study performed in Switzerland concludes that despite the psychological distress caused by subfertility and its treatment, conception with IVF is not associated with maternal depression symptoms during pregnancy and after birth (Gambadauro et al 2017). Results of this study reflect perceptions related with the concepts of social gender and motherhood.…”

Section: Analysis Of Quantitative Studiesmentioning

confidence: 68%

İnfertilitede Anne Olma: Kuramsal Bir Analiz

Boz

Özçetin

Teskereci

2018

Psikiyatride Güncel Yaklaşımlar

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Özİnfertilite nedeniyle bir bebeğe sahip olabilmek için çiftler çoğunlukla yardımcı üreme tedavilerine başvurmaktadır. Gebelik gerçekleştiği durumlarda, çiftler için gebeliğin anlamı mutlu ve keyifli bir süreç olsa da, infertilite tanısı ve tedavilerinin getirdiği yükle birlikte zorlu bir sürece dönüşebilmektedir. Özellikle kadınlar bu süreçte gebeliği kabullenememe, bebeğini kaybetme korkusu, bebeğin sağlığı konusunda endişelenme, belirsizlik gibi duygular yaşayabilmektedirler. İnfertilite tedavisi sonrası gebe kalan kadınların spontan gebeler arasında göz ardı edilebildiği bilinmektedir. Uluslararası literatürde niteliksel çalışmalarda yardımcı üreme tedavileri ile gebe kalan kadınların gebeliğe ve doğum sonu döneme kolayca uyum sağlamadığını göstermektedir. Bu derleme ile, infertilite tedavisi sonrası gebe kalan kadınların anne olma sürecinki deneyimleri kuramsal olarak incelenmiş ve analiz edilmiştir. AbstractIn order to have a baby due to infertility, couples often resort to assisted reproduction therapy. In cases of pregnancy, even if the meaning of pregnancy is a happy and enjoyable process for these couples, the burden of infertility diagnosis and treatments can turn into a challenging process. Especially women can experience emotions such as not accepting pregnancy, fear of losing their baby, worrying about their health, uncertainty. It is known that pregnant women after infertility treatment can be ignored among spontaneous pregnancies. In qualitative studies at international literature, pregnant women with assisted reproductive treatments do not easily adjust to gestation and postpartum period. With this review, the experiences of the mother who became pregnant after infertility treatment were reviewed and analyzed theoretically.

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“…[18,21,28,44,45] Twenty-two of the selected studies were hospital based cohort studies, [18-21, 25-28, 31-34, 36-41, 44, 46, 51, 52] while twelve of the selected studies were population based cohort studies. [17,22,29,30,35,42,43,45,[47][48][49][50] Fourteen studies provided data on exclusively IVF procedures, [17, 19-21, 27-29, 32, 35, 39, 43, 44, 46, 47] and six studies on ICSI procedures. [17,18,27,35,44,47] Five studies reported data on fresh embryo transfer and frozen embryo transfer.…”

Section: Study Characteristicsmentioning

confidence: 99%

Caesarean Section in Pregnancies Conceived by Assisted Reproductive Technology: A Systematic Review and Meta-analysis

Lodge-Tulloch

Elias

Pudwell

et al. 2020

Preprint

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Background: Caesarean section rates are higher among pregnancies conceived by assisted reproductive technology (ART) compared to spontaneous conceptions (SC), implying an increase in neonatal and maternal morbidity. We aimed to compare caesarean section rates in ART pregnancies versus SC, overall, by indication (elective versus emergent), and by type of ART treatment (in-vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), fresh embryo transfer, frozen embryo transfer) in a systematic review and meta‐analysis.Methods: We searched Medline, EMBASE and CINAHL databases using the OVID Platform from 1993-2019, and the search was completed in January 2020. The eligibility criteria were cohort studies with singleton conceptions after in-vitro fertilization and/or intracytoplasmic sperm injection using autologous oocytes versus spontaneous conceptions. The study quality was assessed using the Newcastle Ottawa Scale. Meta-analyses were performed using odds ratios (OR) with a 95% confidence interval (CI) using random effect models in RevMan 5.3, and I-squared (I2) test > 75% was considered as high heterogeneity.Results: 1750 studies were identified from the search of which 34 met the inclusion criteria. Compared to spontaneous conceptions, IVF/ICSI pregnancies were associated with a 1.93-fold increase of odds of caesarean section (95% CI 1.78, 2.09). When stratified by indication, IVF/ICSI pregnancies were associated with a 2.12-fold increase of odds of elective caesarean section (95% CI 1.63, 2.77) and 1.57-fold increase of odds of emergent caesarean section (95% CI 1.27, 1.95). Conclusions: The odds of delivering by caesarean section are greater for ART singleton pregnancies compared to spontaneous conceptions. Preconception and pregnancy care plans should focus on minimizing the risks that may lead to emergency caesarean sections and finding strategies to understand and decrease the rate of elective caesarean sections.

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Conception by means of in vitro fertilization is not associated with maternal depressive symptoms during pregnancy or postpartum

Abstract: Despite the psychologic distress characterizing subfertility and its treatment, conception by means of IVF is not associated with maternal depressive symptoms during pregnancy or postpartum.

Cited by 26 publications

References 43 publications

Perinatal Mood and Anxiety Disorders in Women Undergoing Medically Assisted Reproduction

Perinatal Mood and Anxiety Disorders in Women Undergoing Medically Assisted Reproduction

İnfertilitede Anne Olma: Kuramsal Bir Analiz

Caesarean Section in Pregnancies Conceived by Assisted Reproductive Technology: A Systematic Review and Meta-analysis

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