Concept of Suicide: Neurophysiological/Genetic Theories and Possible Oxytocin Relevance

Pădurariu, Manuela; Prepelita, Raluca; Ciobîcă, Alin; Dobrin, Romeo; Timofte, Daniel; Ștefănescu, Cristinel; Chiriță, Roxana

doi:10.1007/s11062-016-9603-9

Cited by 13 publications

(14 citation statements)

References 56 publications

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“…Thus, the administration of intranasal oxytocin, which will theoretically reach the brain through some various previously described ways [6,7] seems to exert promising effects in disorders such as schizophrenia [1,8], anxiety and depression [9,10], Prader Willi syndrome [3], frontotemporal dementia [11] and of course autism [2,12,13].…”

mentioning

confidence: 99%

Intranasal Oxytocin in Autism: Models, Pain and Oxidative Stress

Pădurariu¹,

Antioch²,

Ciobîcă³

et al. 2017

Rev. Chim.

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There is an increased interest in the current literature in how relevant the administration of oxytocin, mostly by using its intranasal administration, could be in some neuropsychiatric disorders and especially in those manifesting a deficit at their sociability level. These aspects made the possible usage of oxytocin as extremely attractive for some management and treatment solutions in the autistic pathology. Thus, we are describing here some original data and current literature status on how oxytocin could help pathophysiological autistic manifestations in both animal models and human patients, by mainly focusing on some specific behavioural or pain manifestations and related oxidative stress status.

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confidence: 99%

Intranasal Oxytocin in Autism: Models, Pain and Oxidative Stress

Pădurariu¹,

Antioch²,

Ciobîcă³

et al. 2017

Rev. Chim.

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“…as some kind of anti-stress molecule), since it can modulate neuroendocrine axes and adjusting the cortisol levels especially under stressful conditions [30]. There are also important correlations to be mentioned here between cortisol levels and the anxiety-related states [31], since our group also showed some protective effects of oxytocin in anxietyrelated behaviour and a variety of associated neuropsychiatric manifestations [32][33][34][35][36][37][38].…”

Section: Resultsmentioning

confidence: 86%

Serum Cortisol Levels Modifications in Patients with Depression and Irritable Bowel Syndrome

Hrițcu¹,

Pădurariu²,

Ciobîcă³

et al. 2019

Rev. Chim.

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The correlations between depression and stress are quite accepted nowadays, as well as the fact that cortisol levels could also represent fundamental risk factors for major depressive disorder. However, when it comes to the modifications of cortisol levels in depression, the results are controversial. Same goes for the cortisol modifications in irritable bowel syndrome (IBS), which is a functional digestive disorder characterized by a strong biopsychological component, being highly influenced or exacerbated by stressful stimuli. Thus, in the present report we were interested in seeing if there are any serum cortisol levels variations in patients with depression and irritable bowel syndrome, by looking at cortisol modifications in two different groups of patients: a control group with major depression disorder and another study group composed by major depression disorder + IBS patients. Thus, our data presented here are suggesting that there is a significant increase in cortisol levels in the morning serum of the patients with major depression disorder + IBS, as compared to the group having only depression. The results presented here could have an important relevance in the context of managing the stress-related factors in the pathological entities described above.

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“…Especially in AD brain, it decline more rapidly than normal. An increasing body of evidence indicates that the oxidative damage occurs in earliest stage of AD pathogenesis and promotes the formation of other pathological hallmarks of the disease, such as amyloid plaques and neurofibrillary tangles [21]. Therefore, given all the above facts, researchers hypothesized that combining tacrine with an antioxidant fragment might afford more effective multifunctional molecules, which could not only inhibit AChE and reduce the hepatotoxicity of tacrine but also exhibit neuroprotective effect by decreasing the oxidant damage in brain.…”

Section: Introductionmentioning

confidence: 99%