Concentrations of transthyretin (prealbumin) and retinol-binding protein in alcoholics during alcohol withdrawal.

Staley, Michael J.; Naidoo, D.; Pridmore, Saxby

doi:10.1093/clinchem/30.11.1887

Cited by 7 publications

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“…It was surprising that concentrations of transthyretin and RBP significantly decreased with alcohol abstinence. Such a phenomenon has already been noticed (Staley et al, 1984;Takase et al, 1985) and could be due to decreased secretion or escape into the circulation. Because many Lp values were compared, some of the significant ANOVA p values may have been obtained by chance.…”

Section: Discussionmentioning

confidence: 79%

Changes in Serum Apolipoprotein and Lipoprotein Profile After Alcohol Withdrawal: Effect of Apolipoprotein E Polymorphism

Guéguen

Herbeth

Pirollet

et al. 2002

Alcoholism: Clinical and Experimental Research

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Section: Discussionmentioning

confidence: 79%

Changes in Serum Apolipoprotein and Lipoprotein Profile After Alcohol Withdrawal: Effect of Apolipoprotein E Polymorphism

Guéguen

Herbeth

Pirollet

et al. 2002

Alcoholism: Clinical and Experimental Research

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“…Young et al [85] found increased concentrations of TTR in ill-surgical patients receiving anabolic steroids, which may enhance amino acid and water uptake by tissues and increase the utilization of fat. Increased TTR concentrations may be seen in acute alcohol intoxication, caused by the leakage of proteins from damaged hepatic cells [86]. Transthyretin was shown to be upregulated also in Hodgkin´s lymphoma and pancreatic cancer [11,87].…”

Section: Disease Markermentioning

confidence: 99%

Transthyretin in the Evaluation of Health and Disease in Human and Veterinary Medicine

Tóthová¹,

Nagy²

2018

Pathophysiology - Altered Physiological States

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Transthyretin (also known as prealbumin) is an important transport protein, which plays an essential role in the binding of thyroid hormones and retinol with varying affinities in mammalian, as well as avian species. The determination of transthyretin concentrations may be used as a diagnostic tool for some disease conditions in humans, but is more often used as a nutritional marker to assess protein-calorie malnutrition and as prognostic indicator in critically ill patients. Transthyretin has shorter half-life (2-3 days) than that of albumin and belongs to negative acute phase proteins. This may complicate the use of transthyretin as a nutritional marker and the interpretation of results in the diagnosis of diseases. Although some studies have been carried out to determine the usefulness of transthyretin in selected disease conditions and disorders also in animals, it is a relatively rarely used parameter to evaluate health state and illness in veterinary medicine. The usefulness of transthyretin in the diagnosis of diseases and evaluation of nutritional status in humans and animals are reviewed in this article, including the laboratory assays available to measure its concentrations and the possible clinical application of the results, as well as its usefulness as a prognostic indicator in some disease conditions.

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Laboratory assessment of protein-energy status

Shenkin

Cederblad²,

Elia³

et al. 1996

Clinica Chimica Acta

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Concentrations of transthyretin (prealbumin) and retinol-binding protein in alcoholics during alcohol withdrawal.

Cited by 7 publications

References 0 publications

Changes in Serum Apolipoprotein and Lipoprotein Profile After Alcohol Withdrawal: Effect of Apolipoprotein E Polymorphism

Changes in Serum Apolipoprotein and Lipoprotein Profile After Alcohol Withdrawal: Effect of Apolipoprotein E Polymorphism

Transthyretin in the Evaluation of Health and Disease in Human and Veterinary Medicine

Laboratory assessment of protein-energy status

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