Concentrations of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 Antigen in Blood Obtained from the Patients with a First-time, Recurrent, or Chronic Cerebral Infarction

Evaluation of nailfold videocapillaroscopy in central serous chorioretinopathy

“…Steroids can cause CSCR through various effects [27,28]: 1) increased capillary fragility and hyperpermeability; 2) interaction with production of nitric oxide, prostaglandins and free radicals, all which can affect choroidal blood flow and hyperpermeability; 3) inhibition of collagen production which is main component of Bruch's membrane; and 4) increased clotting and choroidal hypo-perfusion. In CSCR, some authors reported increased plasminogen activator inhibitor-1 (PAI-1) levels [28][29][30]. In CSCR, high levels of serum PAI-1 suggest thrombotic mechanisms in these vascular changes [28][29][30].…”

“…In CSCR, some authors reported increased plasminogen activator inhibitor-1 (PAI-1) levels [28][29][30]. In CSCR, high levels of serum PAI-1 suggest thrombotic mechanisms in these vascular changes [28][29][30]. Given the known effects of steroids in the pathogenesis of CSCR, we are interested in whether capillaroscopic findings differ in patients with history of steroid use.…”

Central serous chorioretinopathy and risk of ischaemic stroke: a population-based cohort study

“…Increased cardiovascular morbidity and mortality have been reported in patients with Cushing's syndrome, a condition characterised by chronic endogenous hypercortisolism and considered to be a risk factor for developing CSCR 4 30. Furthermore, in addition to increased concentrations of plasminogen activator inhibitor 1,13 lower levels of tissue plasminogen activator activity have also been found in patients with CSCR 31. On the other hand, it is generally accepted that increasing plasma fibrinogen and low blood fibrinolytic activity are risk factors for ischaemic stroke 32.…”

Increased risk of coronary heart disease in male patients with central serous chorioretinopathy: results of a population-based cohort study

“…Imaging studies on indocyanine green angiography have shown that patients with CSCR have delayed choroidal filling 1. Elevated serum plasminogen activator inhibitor 1 (PAI-1) levels were also observed in these patients 2 3. These results indicate that an imbalance between coagulation/coagulysis may predispose patients to choroidal vasculopathy in CSCR.…”