Concentrations of selected pharmaceuticals and antibiotics in south-central Pennsylvania waters, March through September 2006

Loper, Connie A.; Crawford, Charles G.; Otto, Kim L.; Manning, R.; Meyer, Michael T.; Furlong, Edward T.

doi:10.3133/ds300

Cited by 12 publications

(13 citation statements)

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“…†Locations: Michigan (Batt et al, 2006), New York (Fogarty et al, 2007), Arkansas (Haggard and Bartsch, 2009), and Pennsylvania (Loper et al, 2007). …”

Section: Resultsmentioning

confidence: 99%

“…This study analyzed the fate of three human antibiotics (sulfamethoxazole [SMX], ofloxacin [OFL], and trimethoprim [TMP]; Table 1) in WWTP effluent, soil, and groundwater in an agricultural system where effluent is spray irrigated. These three antibiotics are commonly found at concentrations ranging from nanograms to micrograms per liter in effluent and natural waterways, with higher concentrations typically in effluent, but concentrations in the micrograms per liter range documented in surface waters (Kolpin et al, 2002; Kim et al, 2007; Loper et al, 2007; Watkinson et al, 2007). At these environmental concentrations, ecotoxicological impacts due to chronic exposure are feasible given estimated threshold concentrations as low as 0.5 μg L −1 (Ferrari et al, 2004; Straub, 2013).…”

Section: Characteristics Of the Three Antibiotic Compounds Analyzed Imentioning

confidence: 99%

“…Assessment of Soil to Mitigate Antibiotics in the Environment Due to Release of Wastewater Treatment Plant Effluent Alison M. Franklin,* Clinton F. Williams, and John E. Watson O ver the last two decades, pharmaceuticals, personal care products (PPCPs), and other emerging contaminants have been measured at low but physiologically active levels in the environment (Kolpin et al, 2002;Kim et al, 2007;Loper et al, 2007;Watkinson et al, 2007). Since most wastewater treatment plants (WWTPs) are not designed to completely remove emerging contaminants, these compounds are commonly present at low levels in effluent that is discharged into waterways.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Soil to Mitigate Antibiotics in the Environment Due to Release of Wastewater Treatment Plant Effluent

2018

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With low levels of human antibiotics in the environment due to release of wastewater treatment plant (WWTP) effluent, concern is rising about impacts on human health and antibiotic resistance development. Furthermore, WWTP effluent may be released into waterways used as drinking water sources. The aim of this study was to analyze three antibiotics important to human health (sulfamethoxazole, ofloxacin, and trimethoprim) in soil and groundwater at a long‐term wastewater reuse system that spray irrigates effluent. Soil samples were collected (i) at a site that had not received irrigation for 7 mo (approximate background concentrations), and then at the same site after (ii) one irrigation event and (iii) 10 wk of irrigation. Water samples were collected three times per year to capture seasonal variability. Sulfamethoxazole was typically at the highest concentrations in effluent (22 ± 3.7 μg L−1) with ofloxacin and trimethoprim at 2.2 ± 0.6 and 1.0 ± 0.02 μg L−1, respectively. In the soil, ofloxacin had the highest background concentrations (650 ± 204 ng kg−1), whereas concentrations of sulfamethoxazole were highest after continuous effluent irrigation (730 ± 360 ng kg−1). Trimethoprim was only quantified in soil after 10 wk of effluent irrigation (190 ± 71 ng kg−1). Groundwater concentrations were typically <25 ng L−1 with high concentrations of 660 ± 20 and 67 ± 7.0 ng L−1 for sulfamethoxazole and ofloxacin, respectively. Given that antibiotics interacted with the soil profile and groundwater concentrations were frequently about 1000‐fold lower than effluent, soil may be an adequate tertiary treatment for WWTP effluent leading to improved water quality and protection of human health. Core Ideas Antibiotics in the environment may pose ecological and health risks. Soil may be a natural filter due to its physical and chemical nature. Soil may help to prevent antibiotics from contaminating groundwater. Soil could provide a tertiary treatment for wastewater effluent.

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“…†Locations: Michigan (Batt et al, 2006), New York (Fogarty et al, 2007), Arkansas (Haggard and Bartsch, 2009), and Pennsylvania (Loper et al, 2007). …”

Section: Resultsmentioning

confidence: 99%

Section: Characteristics Of the Three Antibiotic Compounds Analyzed Imentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of Soil to Mitigate Antibiotics in the Environment Due to Release of Wastewater Treatment Plant Effluent

2018

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“…Globally, significant amounts of antibiotics used in domestic treatments, hospitals and cattle farming end up, directly or indirectly, in wastewater (Priyanka and Nandan, 2014). In municipal wastewater and even in natural streams and wells receiving water from agricultural areas dominated by animal-feeding operations, concentrations of different antibiotics remain very high (Loper et al, 2007;Hong et al, 2013;Ju et al, 2018). Wastewater and wastewater treatment plants (WWTPs) are thus considered to be hotspots for dissemination of antibacterial resistance into the environment.…”

Section: Introductionmentioning

confidence: 99%

Insights into the antibiotic resistance dissemination in a wastewater effluent microbiome: bacteria, viruses and vesicles matter

Maestre‐Carballa

Gomez

Navarro

et al. 2019

Environmental Microbiology

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Summary Wastewater treatment plants effluents are considered as hotspots for the dispersion of antibiotic resistance genes (ARGs) into natural ecosystems. The bacterial resistome (ARG collection in a metagenome) analyses have provided clues on antibacterial resistance dynamics. However, viruses and vesicles are frequently ignored. Here, we addressed the bacterial, viral and vesicle resistomes from a representative wastewater effluent in natural conditions and amended with polymyxin, which is used as a last resort antibiotic. Metagenomics showed that the natural prokaryotic resistome was vast (9000 ARG hits/Gb metagenome) and diverse, while viral resistome was two orders of magnitude lower (50 ARG hits/Gb metagenome) suggesting that viruses rarely encoded ARGs. After polymyxin amendment, data showed no ARG enrichment – including to polymyxin – in the microbiome. Remarkably, microbiomes responded to polymyxin with a vast release of putative vesicles (threefold increase compared with the control), which might be used as 'traps' to decrease the antibiotic concentration. Intriguingly, although polymyxin resistance genes (PRGs) were rare in the microbiome (0.018% of total ARG found), in the viral and vesicle fractions, PRGs were more abundant (0.5%–0.8% of total ARG found). Our data suggest that vesicles could have a more active role in the context of transmission of antibiotic resistances.

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“…The committee is reviewing databases and considering the treatability of potential contaminants. Results from this study were used as part of a data set for a nationwide reconnaissance of emerging contaminants in streams (Loper et al, 2007). The outcome of these studies might result in the development of a regulatory framework through which some of the contaminants could be regulated in the near future.…”

mentioning

confidence: 99%

Linear and Non-Linear Models to Predict Removal Efficiencies of Compounds of Emerging Concern (CECs) During Wastewater Treatment

Erdal¹,

Shayamasundar²,

Schimmoller³

2009

proc water environ fed

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Endocrine disrupting compounds (EDCs), pharmaceutically active compounds (PhACs) and personal care products (PCPs), are a substantial subset of emerging contaminants recently named as contaminant of emerging concern (CEC) that have been detected at trace concentrations in municipal wastewater effluents, groundwater and drinking water. CECs have already been detected at concentrations capable of inducing fish feminization and sexual development defects (known as "intersex"). Even though these compounds are not regulated, they have captured the public's attention, and as a result there is intense interest in preventing their release to surface waters, groundwaters and public water supplies. Investigating and collecting data on the fate and removal rates of these constituents during treatment processes is an important step to understand if these constituents exist at levels that are a concern to human health and warrant regulation as MCLs. Investigating removal efficiencies of these compounds during wastewater treatment is also an important step to understand capabilities of the conventional wastewater treatment processes and what additional treatment needs to be provided to reduce these compounds. Although removal efficiencies of the CECs during wastewater treatment are complex and not widely studied, a substantial body of drinking water research indicates that removal efficiencies highly depend on physical and chemical properties of CECs. In this study, using literature findings, simple linear (one variable), multi variable linear and non-linear models are developed to establish CECs removal as function of operating parameters and physical-chemical properties of the compounds. This paper summarizes study findings.

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Concentrations of selected pharmaceuticals and antibiotics in south-central Pennsylvania waters, March through September 2006

Cited by 12 publications

References 1 publication

Assessment of Soil to Mitigate Antibiotics in the Environment Due to Release of Wastewater Treatment Plant Effluent

Assessment of Soil to Mitigate Antibiotics in the Environment Due to Release of Wastewater Treatment Plant Effluent

Insights into the antibiotic resistance dissemination in a wastewater effluent microbiome: bacteria, viruses and vesicles matter

Linear and Non-Linear Models to Predict Removal Efficiencies of Compounds of Emerging Concern (CECs) During Wastewater Treatment

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