Concentrations of riboflavin and related organic acids in children with protein-energy malnutrition

Capo-chichi, Callinice D.; Feillet, François; Guéant, Jean‐Louis; Amouzou, Komla Séna; Zonon, Noël; Sanni, Ambaliou; Lefebvre, E.; Assimadi, K.; Vidailhet, M.

doi:10.1093/ajcn/71.4.978

Cited by 28 publications

(14 citation statements)

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“…10 12-19 Thiamine (Vit B1) * 3.3 (n = 73) 2.5-4.3 2.7 (n = 74) 2.4-3.4 6.8 4.5-7.0 5-12 [129] Thiamine monophosphate (VitB1) 8.5 (n = 105) 6.0-11.4 10.0 c) (n = 93) 7.6-14.1 6.8 5.8-9.0 5-12 [129] Thiamine triphosphate (VitB1) * 4.6 (n = 4) 4.07-5. 28 3.3 (n = 80) 2.8-3.8 9.0 8.4-10.7 5-12 [129] Riboflavin (VitB2) * [130] Flavin adenine dinucleotide (VitB2) 44.8 (n = 100) 36.0-52.0 31.9 c) (n = 95) 28.1-36.9 55.0 30.0-120.0 10-18 [130] Flavin mononucleotide (VitB2) 10.6 (n = 98) 8.2-13.7 8.0 c) (n = 79) 6.7-10.2 13.0 ± 0.7 10.2-18.4 10-18 [130] Nicotinamide (VitB3) 384.0 (n = 106) 310.0-454.0 446.5 c) (n = 97) 369-521.2 261.0 ± 217 20-34 [131] Nudifloramide ( [58] are geometric means. f) Variables were not considered in other analyses since they had more than 25% missing values at any time point.…”

Section: Variability Of Baseline Vitamin Levelsmentioning

confidence: 99%

Clinical and Vitamin Response to a Short‐Term Multi‐Micronutrient Intervention in Brazilian Children and Teens: From Population Data to Interindividual Responses

Mathias¹,

Coelho‐Landell²,

Scott‐Boyer

et al. 2018

Molecular Nutrition Food Res

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ScopeMicronutrients are in small amounts in foods, act in concert, and require variable amounts of time to see changes in health and risk for disease. These first principles are incorporated into an intervention study designed to develop new experimental strategies for setting target recommendations for food bioactives for populations and individuals.Methods and resultsA 6‐week multivitamin/mineral intervention is conducted in 9–13 year olds. Participants (136) are (i) their own control (n‐of‐1); (ii) monitored for compliance; (iii) measured for 36 circulating vitamin forms, 30 clinical, anthropometric, and food intake parameters at baseline, post intervention, and following a 6‐week washout; and (iv) had their ancestry accounted for as modifier of vitamin baseline or response. The same intervention is repeated the following year (135 participants). Most vitamins respond positively and many clinical parameters change in directions consistent with improved metabolic health to the intervention. Baseline levels of any metabolite predict its own response to the intervention. Elastic net penalized regression models are identified, and significantly predict response to intervention on the basis of multiple vitamin/clinical baseline measures.ConclusionsThe study design, computational methods, and results are a step toward developing recommendations for optimizing vitamin levels and health parameters for individuals.

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Section: Variability Of Baseline Vitamin Levelsmentioning

confidence: 99%

Clinical and Vitamin Response to a Short‐Term Multi‐Micronutrient Intervention in Brazilian Children and Teens: From Population Data to Interindividual Responses

Mathias¹,

Coelho‐Landell²,

Scott‐Boyer

et al. 2018

Molecular Nutrition Food Res

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“…Protein/energy malnutrition has been identified as a factor resulting in deficiency of vitamins A, C and E, thiamine and biotin without significant influence on B 12 and folic acid concentration in the blood. Children with severe malnutrition have higher plasma riboflavin (B 6 ) concentration but much lower flavine‐adenine dinucleotide (FAD) concentration because of inhibition of riboflavin kinase activity responsible for conversion of this vitamin into flavine mononucleotide (FMN) and FAD (Capo‐chichi et al., 2000). In children suffering from malnutrition, higher excretion of riboflavin was also reported (Consolazio et al., 1971).…”

Section: Introductionmentioning

confidence: 99%

The Influence of Folic Acid, Vitamins B₂ and B₆ Supplementation on Feed Intake, Body and Organs Weight, and Liver Fatty Acids Composition of Rats Subjected to 3 months Moderate Protein Deprivation

Debski¹,

Bertrandt

Kłos

et al. 2007

Journal of Veterinary Medicine Series A

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This study was conducted to determine the effect of a 3-month dietary protein restriction - protein provided 9% of energy (20% in control group). In this dietary restriction folic acid, vitamins B(2) and B(6) were delivered in amount three times above the standard level. It was observed that animals fed a protein restricted (PR) diet weighed about 5% less than animals consuming adequate diet, but the difference was not statistically significant. Enrichment of PR diet with vitamin B or folic acid caused tendency to further suppression of weight gain, and in case of vitamin B(6) these differences were statistically significant. However, such body weight (BW) suppression was not observed when all studied vitamins were used together. Significant reductions in relative liver weight (vitamin B(2) addition), the heart (folic acid) and the lungs (vitamin B(6)) were observed. The PR diet, when all vitamins were added together, caused a decrease in weights of the lungs, heart and liver scaled to BW of rats, simultaneously with a significant increase in testis weight. Feed intake and feed conversion ratio were higher in animals given PR diet without a significant influence of vitamin supplementation (except vitamin B(6) causing further increase in feed conversion ratio). Hepatic fatty acids composition of rats was not affected by protein restriction, as well as by single vitamin supplementation. However, dietary supplementation of all examined vitamins together caused a decrease in monounsaturated fatty acids followed by an increase in polyunsaturated fatty acids participation in total fatty acids pool. It seems that enrichment of PR diet with a mixture of folic acid, vitamins B(2) and B(6) resulted in a partial reverse of growth suppression and reduction in testis size in rats.

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“…CBS). Considering that both hHCY and acute hypoxia may simultaneously occur in neonates, particularly in some populations at risk of malnutrition (22)(23)(24)(25), we aimed to evaluate the effects of transient neonatal hypoxia on liver HCY metabolism in a rat model of nutritionally induced hHCY during pregnancy.…”

mentioning

confidence: 99%

Mild Neonatal Hypoxia Exacerbates the Effects of Vitamin-Deficient Diet on Homocysteine Metabolism in Rats

et al. 2005

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Elevated plasma homocysteine has been linked to pregnancy complications and developmental diseases. Whereas hyperhomocysteinemia is frequently observed in populations at risk of malnutrition, hypoxia may alter the remethylation of homocysteine in hepatocytes. We aimed to investigate the combined influences of early deficiency in nutritional determinants of hyperhomocysteinemia and of neonatal hypoxia on homocysteine metabolic pathways in developing rats. Dams were fed a standard diet or a diet deficient in vitamins B12, B2, folate, month, and choline from 1 mo before pregnancy until weaning of the offspring. The pups were divided into four treatment groups corresponding to "no hypoxia/standard diet," "hypoxia (100% N2 for 5 min at postnatal d 1)/standard diet," "no hypoxia/ deficiency," and "hypoxia/deficiency," and homocysteine metabolism was analyzed in their liver at postnatal d 21. Hypoxia increased plasma homocysteine in deficient pups (21.2 Ϯ 1.6 versus 13.3 Ϯ 1.2 M, p Ͻ 0.05). Whereas mRNA levels of cystathionine ␤-synthase remained unaltered, deficiency reduced the enzyme activity (48.7 Ϯ 2.9 versus 83.6 Ϯ 6.3 nmol/h/mg, p Ͻ 0.01), an effect potentiated by hypoxia (29.4 Ϯ 4.7 nmol/h/mg, p Ͻ 0.05). The decrease in methylene-tetrahydrofolate reductase activity measured in deficient pups was attenuated by hypoxia (p Ͻ 0.05), and methionine-adenosyltransferase activity was slightly reduced only in the "hypoxia/deficiency" group (p Ͻ 0.05). Finally, hypoxia enhanced the deficiency-induced drop of the S-adenosylmethionine/S-adenosylhomocysteine ratio, which is known to influence DNA methylation and gene expression. In conclusion, neonatal hypoxia may increase homocysteinemia mainly by decreasing homocysteine transsulfuration in developing rats under methyl-deficient regimen. Plasma accumulation of HCY is known to be linked to cardiovascular diseases and ageing-associated disabilities (1-3). Moderate hHCY can arise from genetic determinants (4,5) but is also frequently related to dietary deficiency in vitamins B12, B2, and folate. In newborns, the risk of hHCY is closely related to elevated maternal HCY concentrations during pregnancy, which is determined by the status of B vitamins (6 -8).A strong relationship has been documented between HCY accumulation and pregnancy complications, including recurrent miscarriages, preeclampsia, and placenta abruption (see Ref. 9 for review). In the progeny, hHCY has been associated with fetal death (10), premature birth (11), intrauterine growth retardation (12), neural tube defects (13), craniofacial anomalies (14), cardiac malformation (15), and hepatic steatosis (16).HCY production involves the demethylation of methionine, and, under normal conditions, is essentially regulated in the liver. As summarized in Figure 1, it originates from the hydrolysis of SAH, a product of transmethylation reactions through SAM, and is metabolized via two pathways of remethylation and one pathway of transsulfuration. HCY metabolism strongly depends on the nutritional intake of B vitamins,

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Concentrations of riboflavin and related organic acids in children with protein-energy malnutrition

Abstract: Children in group S had low triiodothyronine concentrations and low conversion of plasma riboflavin into its cofactors, leading to a plasma FAD deficiency. Plasma FAD was not correlated with urinary dicarboxylic acid concentrations.

Cited by 28 publications

References 31 publications

Clinical and Vitamin Response to a Short‐Term Multi‐Micronutrient Intervention in Brazilian Children and Teens: From Population Data to Interindividual Responses

Clinical and Vitamin Response to a Short‐Term Multi‐Micronutrient Intervention in Brazilian Children and Teens: From Population Data to Interindividual Responses

The Influence of Folic Acid, Vitamins B₂ and B₆ Supplementation on Feed Intake, Body and Organs Weight, and Liver Fatty Acids Composition of Rats Subjected to 3 months Moderate Protein Deprivation

Mild Neonatal Hypoxia Exacerbates the Effects of Vitamin-Deficient Diet on Homocysteine Metabolism in Rats

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Concentrations of riboflavin and related organic acids in children with protein-energy malnutrition

Abstract: Children in group S had low triiodothyronine concentrations and low conversion of plasma riboflavin into its cofactors, leading to a plasma FAD deficiency. Plasma FAD was not correlated with urinary dicarboxylic acid concentrations.

Cited by 28 publications

References 31 publications

Clinical and Vitamin Response to a Short‐Term Multi‐Micronutrient Intervention in Brazilian Children and Teens: From Population Data to Interindividual Responses

Clinical and Vitamin Response to a Short‐Term Multi‐Micronutrient Intervention in Brazilian Children and Teens: From Population Data to Interindividual Responses

The Influence of Folic Acid, Vitamins B2 and B6 Supplementation on Feed Intake, Body and Organs Weight, and Liver Fatty Acids Composition of Rats Subjected to 3 months Moderate Protein Deprivation

Mild Neonatal Hypoxia Exacerbates the Effects of Vitamin-Deficient Diet on Homocysteine Metabolism in Rats

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The Influence of Folic Acid, Vitamins B₂ and B₆ Supplementation on Feed Intake, Body and Organs Weight, and Liver Fatty Acids Composition of Rats Subjected to 3 months Moderate Protein Deprivation