Concentrations of psychoactive substances in blood samples from non‐fatal and fatal opioid overdoses

Edvardsen, Hilde Marie Erøy; Aamodt, Carl; Bogstrand, Stig Tore; Krajči, Peter; Vindenes, Vigdis; Rognli, Eline Borger

doi:10.1111/bcp.15365

Cited by 5 publications

(4 citation statements)

References 32 publications

(81 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This may seem high in comparison with the literature; for example, Edvardsen et al. [38] found that the median number of drugs present in fatal opioid overdose cases was four, and five for non‐fatal opioid overdoses. This difference can be explained by differences in drug concentrations, suggesting that both the combination of high levels of these drugs, and the number of different drugs present are important factors to consider.…”

Section: Discussionmentioning

confidence: 72%

“…Edvardsen et al. [38] reported concentrations between 0.09 and 5.57 ng/mL, observing a linear relationship between the blood concentration of naloxone and the concomitant pooled opioid concentration. We did not observe the same trend, as the concentrations for four of the five most frequently detected opioids were not significantly different between groups.…”

Section: Discussionmentioning

confidence: 99%

“…We did not observe the same trend, as the concentrations for four of the five most frequently detected opioids were not significantly different between groups. Edvardsen et al [38] suggest that higher doses of naloxone may be needed to effectively treat more severely affected and sedated patients; however, with fatal overdoses, the naloxone dose used was not effective, so this relationship is less relevant. It is possible that the high naloxone concentrations observed were the result of multiple doses being administered in a life-saving effort to reverse respiratory depression [35].…”

Section: Number Of Casesmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence and blood concentrations of benzodiazepines and opioids in opioid‐positive death investigations in Ontario, Canada, from 2017 to 2021

Mocanu,

Woodall,

Solbeck

2024

Journal of Forensic Sciences

View full text Add to dashboard Cite

The aim of this study was to investigate the incidence of benzodiazepines in opioid‐positive death investigations, including trends in frequency and combination of drugs, as well as demographic data and blood concentrations, where available. Additionally, naloxone concentrations in polysubstance compared to opioid‐only cases were analyzed. This was a retrospective study that consisted of all post‐mortem toxicology cases in Ontario, Canada, from January 01, 2017, to December 31, 2021, with an opioid finding in any analyzed autopsy specimen. There were 11,033 death investigations identified. The overall rate of benzodiazepine co‐involvement was 54.5%. Males accounted for the majority of cases (71%), and the most affected age group was 30‐ to 39‐year‐olds. The most frequently detected opioid was fentanyl and the most frequently detected benzodiazepine was etizolam, which was also the most frequently observed opioid/benzodiazepine combination. Findings related to differences in concentrations of opioids when naloxone was also present were mostly non‐significant, except for methadone. The rate of benzodiazepine detection with opioids grew faster than opioid detections overall, potentially due to the increasingly toxic drug supply. Detection of novel psychoactive drugs fluctuated more unpredictably than opioids and benzodiazepines associated with clinical use. These findings can help inform policy decisions by public health agencies in exploring harm reduction efforts, for example, education and drug‐checking services.

show abstract

Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Number Of Casesmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence and blood concentrations of benzodiazepines and opioids in opioid‐positive death investigations in Ontario, Canada, from 2017 to 2021

Mocanu,

Woodall,

Solbeck

2024

Journal of Forensic Sciences

View full text Add to dashboard Cite

show abstract

“…Da samarbeidet ble inngått, ble det knyttet følgeforskning til tilbudet for å se på pasientkarakteristika og blodkonsentrasjoner av rusmidler hos pasientene (11). Vi fulgte derfor nøye med på hvor mange som benyttet seg av tilbudet.…”

Section: K O N T E K S T F O R S T U D I E Nunclassified

Ubenyttet behandlingstilbud ved rusakuttmottak – en kvalitativ studie

Rognli¹,

Dalsrud²,

Wüsthoff³

et al. 2023

Tidsskriftet

Self Cite

View full text Add to dashboard Cite

Seksjon for klinisk rus-og avhengighetsforskning (RusForsk) Klinikk psykisk helse og avhengighet Oslo universitetssykehus Forfatterbidrag: forskningsidé, skaffet midler, lagt til rette for innsamling av data, analyse av data, hovedansvar for skriving av manuskript. Eline Borger Rognli er ph.d., spesialist i rus-og avhengighetspsykologi og forsker. Forfatteren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. Barn av rusmisbrukere Oslo Forfatterbidrag: datainnsamling, transkribert intervjuer, deltatt i analyse av data, skriving av manuskript. Martine Kihle Dalsrud er adjunkt og fagansvarlig. Hun er under videreutdanning i samarbeidsbasert forskning i psykisk helsearbeid. Forfatteren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. Seksjon for klinisk rus-og avhengighetsforskning (RusForsk) Klinikk psykisk helse og avhengighet Oslo universitetssykehus og Senter for rus og avhengighetsforskning (SERAF) Institutt for klinisk medisin Universitetet i Oslo Forfatterbidrag: skriving av manuskript. Linda Elise Couëssurel Wüsthoff er ph.d., spesialist i psykiatri og samfunnsmedisin og forsker. Forfatteren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. Seksjon for klinisk rus-og avhengighetsforskning (RusForsk) Klinikk psykisk helse og avhengighet Oslo universitetssykehus Forfatterbidrag: forskningsidé, analyse av data, skriving av manuskript. Espen Ajo Arnevik er ph.d., psykolog og seksjonsleder. Forfatteren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter.

show abstract

Carfentanil overdose

2022

Reactions Weekly

View full text Add to dashboard Cite

Concentrations of psychoactive substances in blood samples from non‐fatal and fatal opioid overdoses

Cited by 5 publications

References 32 publications

Prevalence and blood concentrations of benzodiazepines and opioids in opioid‐positive death investigations in Ontario, Canada, from 2017 to 2021

Prevalence and blood concentrations of benzodiazepines and opioids in opioid‐positive death investigations in Ontario, Canada, from 2017 to 2021

Ubenyttet behandlingstilbud ved rusakuttmottak – en kvalitativ studie

Carfentanil overdose

Contact Info

Product

Resources

About