Concentrations of polychlorinated dibenzodioxins, polychlorodibenzofurans, and polychlorobiphenyls in women of reproductive age in Italy: A human biomonitoring study

Ingelido, Anna Maria; Abate, Vittorio; Abballe, Annalisa; Albano, Fulvia Lucia; Battista, Tatiana; Carraro, Valter; Conversano, Michele; Corvetti, Rosa; Luca, Silvia De; Franchini, S; Fulgenzi, Anna Rita; Giambanco, Laura; Iacovella, Nicola; Iamiceli, Anna Laura; Maiorana, Antonio; Maneschi, Francesco; Marra, Valentina; Pirola, Flavia; Porpora, Maria Grazia; Procopio, Enrico; Suma, N.; Valentini, Silvia; Valsenti, Luisa; Vecchiè, Valerio; Felip, Elena De

doi:10.1016/j.ijheh.2016.11.009

Cited by 20 publications

(10 citation statements)

References 31 publications

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“…The available data are related to the presence of the substances in the various environmental matrices, not necessarily to their concentrations. The existence of human biomonitoring data (blood, serum, and milk) reporting high levels of endocrine disrupting chemicals and other monitoring data (food and plants) regarding the NPCSs was verified by a search in PubMed [39,40,41,42,43,44,45,46,47,48,49,50,51,52]. …”

Section: Methodsmentioning

confidence: 99%

Incidence of Breast, Prostate, Testicular, and Thyroid Cancer in Italian Contaminated Sites with Presence of Substances with Endocrine Disrupting Properties

Benedetti

Zona

Beccaloni

et al. 2017

IJERPH

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The aim of the present study was to investigate the incidence of breast (females), prostate, testicular, and thyroid cancer in the Italian National Priority Contaminated Sites (NPCSs), served by cancer registries, where the presence of endocrine disruptors (EDs), reported to be linked to these tumours, was documented. Evidence of carcinogenicity of EDs present in NPCSs was assessed based on evaluation by international scientific institutions and committees. Standardized Incidence Ratios (SIRs) were computed for each NPCS and cancer site between 1996 and 2005. Excess incidence of one or more cancer site studied was found in twelve out of fourteen NPCSs. Significantly increased SIRs were found for breast cancer in eight NPCSs, for prostate cancer in six, for thyroid cancer (both gender) in four, and for testicular cancer in two. Non-significantly increased SIRs were found in five NPCSs for testicular cancer and in two for thyroid cancer (males). In a small number of instances a significant deficit was reported, mainly for thyroid and prostate cancer. Although increased incidence of one or more cancer sites studied were found in several NPCSs, the ecological study design and the multifactorial aetiology of the considered tumours do not permit concluding causal links with environmental contamination. Regarding the observation of some excesses in SIRs, continuing epidemiological surveillance is warranted.

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Section: Methodsmentioning

confidence: 99%

Incidence of Breast, Prostate, Testicular, and Thyroid Cancer in Italian Contaminated Sites with Presence of Substances with Endocrine Disrupting Properties

Benedetti

Zona

Beccaloni

et al. 2017

IJERPH

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“…The available data are related to the presence of the substances in the various environmental matrices (soil, groundwater, and sea), not to their concentrations. By a search in PubMed, Web of Science, and other sources it was verified: (a) the existence of biomonitoring data reporting presence of high levels of EDs in residents in the NPCSs; and (b) other food and plants monitoring data [57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72].…”

Section: Npcss Descriptionmentioning

confidence: 99%

Incidence of Thyroid Cancer in Italian Contaminated Sites

Benedetti

Zona

Contiero

et al. 2020

IJERPH

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Some human literature suggests a possible role of endocrine disruptors (EDs) exposure in thyroid cancer (TC) development. We investigated TC incidence in selected Italian National Priority Contaminated Sites (NPCS) with documented presence of EDs considered thyroid carcinogens. Adjusted Standardized Incidence Ratios (SIRs), with their 90% confidence intervals, were computed by gender, and age-specific groups (aged 15–39 years, and 40 years or over) for each NPCS in the period 2006 to 2013. In the age group of 15–39 years, a significant excess of TC risk was found in two NPCSs in males; non-significant excess risks were observed in four NPCSs in males, and in five in females. In the age group of 40 years and over, significant excess risks were found in six NPCSs in males and in seven NPCSs in females; non-significant excess risks were identified in two NPCSs in males and females. The findings of several excesses in incidence, mainly observed in adults aged 40 years or over, are suggestive of a possible adverse effect associated with residence in NPCSs, even if a role of other factors cannot be excluded, due to the adoption of an ecological study design. Future analytical studies are needed to clarify if EDs are a TC risk factor for individuals living in NPCSs.

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“…To reach this objective, all European Nations should standardize and regulate the application of tools such as the evaluation of health impact from prevention departments of the local health units to plan controls and prevent environmental emergencies, which would otherwise be more complex to manage. (5) In order to improve the performances of hospital and primary health care departments, it would be desirable to allocate these functions to health professionals who specialize in hygiene, preventive medicine, and to train students of public health in Italian post-graduate schools (24).…”

Section: Actionable Recommendations: the Erice Declarationmentioning

confidence: 99%

“…More recently, environmental emergencies due to perfluoroalkylated substances in the North East of the Italy (Veneto region) ( 23 ) and, in the South Italy, to polychlorinated biphenyls (PCBs) dioxins-specific (Taranto, Apulia region) ( 24 ) and to pollutants emitted from waste management on fire in Sicily island ( 25 ), reaffirmed the need to plan preventive controls and strategies to reduce any types of pollutants in the environmental media and to establish and legislate, based on the most recent scientific evidence, any limits to exposure, if not yet defined.…”

Section: Policy Options and Implicationsmentioning

confidence: 99%

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Proposal for an Alliance Between Healthcare and Legal Area Professionals for Shared Public Health and Preventive Strategies in Italy and Europe

Costantino

Mazzucco

Restivo

et al. 2020

Front. Public Health

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Following the implementation of the new Italian legislation on responsibility of healthcare workers, a multi-professional framework, involving representatives of the Italian public health professionals and legal professionals expert in the field, drafted a proposal of the actionable recommendations to be implemented in the management of civil and penal disputes arising from the practice of public health interventions. In order to prevent legal disputes concerning some public health fields such as vaccinations, cancer screening, environmental health surveillance, and hospital management, it should be primary taken into account to update guidelines in supporting decision-making processes, in accordance with the "best scientific evidence available." Furthermore, a multidisciplinary alliance between public health and legal area professionals should be encouraged and should be promoted both at national and European level.

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Concentrations of polychlorinated dibenzodioxins, polychlorodibenzofurans, and polychlorobiphenyls in women of reproductive age in Italy: A human biomonitoring study

Cited by 20 publications

References 31 publications

Incidence of Breast, Prostate, Testicular, and Thyroid Cancer in Italian Contaminated Sites with Presence of Substances with Endocrine Disrupting Properties

Incidence of Breast, Prostate, Testicular, and Thyroid Cancer in Italian Contaminated Sites with Presence of Substances with Endocrine Disrupting Properties

Incidence of Thyroid Cancer in Italian Contaminated Sites

Proposal for an Alliance Between Healthcare and Legal Area Professionals for Shared Public Health and Preventive Strategies in Italy and Europe

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