2020
DOI: 10.1590/1678-5150-pvb-6102
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Concentrations of matrix metalloproteinase-2 and interleukin-1 β in the aqueous humor of dogs with normal and cataractous eyes

Abstract: We aimed to determine the concentration of MMP-2 and IL-1β in the aqueous humor of dogs with healthy eyes (n=8) and in those with mature (n=8) and hyper mature cataracts (n=8). Correlations between cytokines, cytokines, and intraocular pressure (IOP), as well as cytokines with ages of patients of each group, were also assessed. In patients with cataract, aqueous humor was collected at the end of the electroretinographic procedure. In healthy dogs, aqueous humor was collected before elective surgeries. Cytokine… Show more

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“…In humans with anterior uveitis, specific pro-inflammatory cytokines have been detected in aqueous humor (AH) including Interleukin (IL)-6, IL-8, IL-10, IL-13, IL-17, interferon-gamma (IFNγ), and tumor necrosis factor-alpha (TNFα) [19][20][21][22]. In dogs, IL-1β levels evaluated by enzyme-linked immunosorbent assay (ELISA) were increased in AH of eyes with cataracts [23]. In horses, IL-10, IL-17, IL-23, and IFNγ have shown potential for being important pro-inflammatory cytokines in horses with equine recurrent uveitis [24].…”
Section: Introductionmentioning
confidence: 99%
“…In humans with anterior uveitis, specific pro-inflammatory cytokines have been detected in aqueous humor (AH) including Interleukin (IL)-6, IL-8, IL-10, IL-13, IL-17, interferon-gamma (IFNγ), and tumor necrosis factor-alpha (TNFα) [19][20][21][22]. In dogs, IL-1β levels evaluated by enzyme-linked immunosorbent assay (ELISA) were increased in AH of eyes with cataracts [23]. In horses, IL-10, IL-17, IL-23, and IFNγ have shown potential for being important pro-inflammatory cytokines in horses with equine recurrent uveitis [24].…”
Section: Introductionmentioning
confidence: 99%