Concentrations of gentamicin in serum and bronchial lavage fluid after intravenous and aerosol administration of gentamicin to horses

Abstract

Aerosol administration of gentamicin to healthy horses resulted in gentamicin concentrations in bronchial fluid that were significantly greater than those obtained after IV administration. A mild inflammatory cell response was associated with aerosol delivery of gentamicin and repeated bronchial lavage. Aerosol administration of gentamicin may have clinical use in the treatment of bacterial bronchopneumonia in horses.

Concentrations of gentamicin in serum and bronchial lavage fluid after once-daily aerosol administration to horses for seven days

“…3 Samples of BLF were processed as described elsewhere. The timing of all sample collections was the same in treated and untreated horses.…”

“…3 Differential cell counts were reported as the number of cells per 200 cells. The modified assay provided coefficients of variation within and between days of < 5% for BLF and < 10% for serum, respectively.…”

“…[1][2][3][4][5][6] Aerosol administration of antimicrobials may also allow for a decrease in the total dose administered, rapid onset of action, and avoidance of systemic effects. [1][2][3][4][5][6] Aerosol administration of antimicrobials may also allow for a decrease in the total dose administered, rapid onset of action, and avoidance of systemic effects.…”

Antimicrobial drug concentrations and sampling techniques in the equine lung

“…The possible confounding effect of repeated sampling in the same lung can be addressed by sampling in different lung sites (e.g. left ventral, right ventral, left dorsal, right dorsal) in sequential order (McKenzie III and Murray, 2000). However, the quantity of PELF in aspirated BAL fluid (BALF) is often small and variable (Dargaville et al, 1999) which complicates the interpretation of solute concentrations between BALs.…”

Inhalation therapy for equine lower respiratory tract disease

“…Indeed, the achievement of high and prolonged drug concentrations within the airways while maintaining low serum concentrations has been clearly demonstrated with various antibiotics (gentamicin and marbofloxacin) when aerosolised delivery has been compared with systemic (intravenous) administration (McKenzie and Murray 2000, Art and others 2007). …”