Concentrations of ceftriaxone (1,000 milligrams intravenously) in abdominal tissues during open prostatectomy

Abstract

Ceftriaxone concentrations in abdominal tissues were evaluated at different stages of open prostatectomy. Ceftriaxone was administered as antibiotic prophylaxis, and 15 consecutive patients were given a single dose of ceftriaxone (1,000 mg intravenously in 1 min) 30 min before surgery. Ceftriaxone concentrations in tissue were determined at three stages of the surgical procedure; upon the opening of the abdominal cavity, during the prostatectomy, and upon the closure of the abdominal cavity. Samples of the following tissues or sample were assayed: epiploic and abdominal-wall fat; Retzius' space, bladder, and prostate tissue; and urine. During the different stages of the surgical procedure, for all patients, and in the different tested tissues, ceftriaxone concentrations greater than or equal to the cutoff point (4 micrograms/g of tissue) were measured. The highest concentrations were obtained in the bladder (43 +/- 18 micrograms/g) and in the prostate (35 +/- 18 micrograms/g). In fatty tissues, concentrations were between 13 +/- 5 and 22 +/- 8 micrograms/g. All patients (15 of 15) had ceftriaxone levels in tissue greater than the MICs for the potential pathogens (Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis). In conclusion, during open prostatectomy and after the use of a single dose of ceftriaxone (1,000 mg), high antibiotic levels were obtained throughout the surgical procedure in the tissues potentially involved in postoperative infection.

Cephalosporins for first febrile urinary tract infection from Enterobacteriaceae with antimicrobial resistance in young children

“…Interpretation of in vitro antibiotic susceptibility is based on achievable serum concentrations, which could differ from drug levels in the urine. Urine concentrations of ceftriaxone after a single 1000‐mg intravenous injection were three times higher than serum concentrations, and urine concentrations were tenfold greater than the minimum inhibitory concentration of 4 µg/g of tissue 5 . The high treatment success rate and the low UTI relapse rate in our study could be attributed to the initial intravenous G3C.…”

Penetration of cefuroxime in subcutaneous tissue during coronary artery bypass grafting surgery

“…A review of the literature demonstrated that there are some reports that describe the measurement of cefuroxime and other cephalosporins in several biological matrices such as bone tissue, abdominal fat, and heart tissue [10][11][12][13][14][15][16][17].…”

“…To prevent infections after cardiac surgery, it is important to ensure the presence of adequate plasma concentrations of the antibiotic, thus permitting access of the drug to the site of highest bacterial exposure [10].…”

Ceftriaxone for the Treatment of Chronic Bacterial Prostatitis: A Case Series and Literature Review

“…In this study, before determination of tissue concentration, 100 mg of prostatic tissue was crushed with 1 milliliter of isotonic saline solution. This could have led to a wide spread of the tissue concentration [ 13 ]. Currently, micro-dialysis is used to counter this variation in determined tissue concentration; the reported values could be seen as estimates of the real value [ 14 ].…”