Concentrations of C-reactive protein, serum amyloid A, and haptoglobin in uterine arterial and peripheral blood in bitches with pyometra

Dąbrowski, Roman; Kostro, K.; Szczubiał, Marek

doi:10.1016/j.theriogenology.2013.05.012

Cited by 30 publications

(26 citation statements)

References 26 publications

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“…The maximum serum levels of CRP on day 1 and of Hp on day 3 after experimental induction of inflammation observed in controls demonstrate that CRP is the major whereas Hp a moderate APP in dogs [2, 3, 6, 7, 11, 13], which is additionally confirmed by the results in dogs with inflammation and after vaccination (group II, Fig. 2).…”

Section: Discussionsupporting

confidence: 66%

Effects of subclinical inflammation on C-reactive protein and haptoglobin levels as well as specific humoral immunity in dogs vaccinated against canine distemper and parvovirus

2018

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BackgroundThe aim of the present study was to assess the effects of subclinical inflammation on specific humoral immunity in dogs vaccinated with Nobivac® DHP based on serum levels of CRP and Hp. Dogs from the group I were administered Nobivac® DHP, the vaccine against distemper, infectious hepatitis and parvovirus whereas group II animals received subcutaneous turpentine oil to induce subclinical inflammation, followed by Nobivac® DHP after 24 h. Animals in group III received only turpentine oil in the way and amount identical to that as in group II.ResultsNobivac DHP relatively poorly induced the immune inflammatory response showing good immunogenic properties, which was evidenced by only a double increase in mean CRP and Hp levels associated with antigenic stimulation in group I. In group II, serum neutralization (SN) and haemagglutination inhibition (HI) results were quite closely correlated with serum levels of CPR and Hp.ConclusionsOur findings suggest that the efficacy of vaccinations in dogs can be significantly affected by subclinical inflammations, which is indicated by a correlation between serum CRP and Hp levels versus antibody titres for canine distemper and parvovirus in both experimental groups of dogs (group I and II). The correlation of mean CRP and Hp values in dogs with subclinical inflammation and after vaccination with the kinetics of increasing antibody titres against distemper and parvovirus in group II dogs reflects the severity of inflammatory response and the extent of specific humoral immunity. Routine determinations of serum CRP and Hp levels as the indices of inflammation severity can be the essential biochemical markers for assessment of dogs’ health in the period preceding specific immunoprophylaxis and efficacy of the vaccine.

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Section: Discussionsupporting

confidence: 66%

Effects of subclinical inflammation on C-reactive protein and haptoglobin levels as well as specific humoral immunity in dogs vaccinated against canine distemper and parvovirus

2018

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“…Gram-negative bacteria-derived lipopolysaccharides activate B lymphocytes, thereby inducing polyclonal gammopathy, and were shown to induce immune-mediated nephritis, uveitis, myocarditis and arthritis in experimental animals studies (Yoshio and others 2000). A recent study (Dabrowski and others 2013) has documented higher uterine arterial blood as well peripheral venous blood concentrations of C reactive protein, serum amyloid-A and haptoglobin in bitches with closed-cervix pyometra compared with those with an open-cervix disease, thereby suggesting that inflammation is more pronounced in the former dogs. This may potentially account for the higher frequency of GAL in closed-cervix pyometra in the present study, assuming that arthritis may be more common in such dogs.…”

Section: Discussionmentioning

confidence: 99%

“…Secondly, visceral pain, pressure, discomfort and referred pain affecting the spinal cord, nerves or pelvic musculature, resulting from uterine distension and inflammation might have induced lameness, weakness or reluctance to walk (Birnbaum and others 1998, Prescott and others 2002). It is reasonable to assume that in closed-cervix pyometra, uterine size is larger in most cases compared with its size in open-cervix disease (Dabrowski and others 2013), thereby applying more pressure and discomfort in the former. Possibly, this may have played a role in the higher frequency of GAL in bitches with closed-cervix pyometra.…”

Section: Discussionmentioning

confidence: 99%

Hindlimb lameness and gait abnormalities in bitches with pyometra

et al. 2014

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The objective of this study was to assess the frequency of gait abnormalities and lameness (GAL) in bitches with pyometra, and their association with clinical and laboratory findings. The study included 79 bitches diagnosed with pyometra and 35 negative control intact bitches presented with other soft tissue surgical disorders. Dogs with a history of chronic lameness due to orthopaedic or neurological origin were excluded. A history of GAL was more frequent in the pyometra group (47 per cent) compared with the control group (20 per cent) (P=0.007). In the pyometra group, bitches presenting GAL had (P<0.04) higher frequencies of closed-cervix pyometra, anorexia and vomiting, as well as higher serum creatinine concentration and muscle enzymes activity, compared with those in without GAL. GAL signs resolved postovariohysterectomy in all but one bitch. The results suggest that GAL signs occur frequently in bitches with pyometra, especially in closed-cervix disease. Therefore, pyometra should be considered among the differential diagnoses when GAL occurs, especially when the clinical signs are non-specific and the reproductive history is unclear.

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“…In pyometra (Figure 3), CRP, SAA and haptoglobin were valid indicators of the infl ammatory state of the uterus and systemic infl ammation mainly caused by E. coli endotoxins, making it possible to differentiate between open and closed cervix infections and to evaluate the severity of the infl ammatory process especially with post-surgical complications [10,29,30]. A recent study demonstrated the clinical value of SAA determination in bitches with signifi cant differences between septic (130.8 mg/L) and non-septic pyometra (88.5 mg/L) while CRP values did not show signifi cant differences between both groups.…”

Section: Dogsmentioning

confidence: 99%

“…Additionally, CRP concentration in combination with Figure 3. Overview of C-reactive protein, haptoglobin and serum amyloid A concentrations in pyometra in bitches [3,10,29,30,32,34] the percentage of band neutrophils was useful to differentiate between pyometra and cystic endometrial hyperplasia. CRP showed 97.7% sensitivity and 75% specifi city in predicting the presence of pyometra [34].…”

Section: Dogsmentioning

confidence: 99%

Acute Phase Proteins as Markers of Infectious Diseases in small Animals / Proteini Akutne Faze Kao Markeri Infektivnih Bolesti Malih Životinja

Schmidt

Eckersall

2015

Acta Veterinaria

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During the acute phase response, there is an increased production and release of certain proteins known as acute phase proteins (APPs) which can be produced by hepatocytes and peripheral tissues such as C-reactive protein (CRP), serum amyloid A (SAA), haptoglobin (Hp), alpha-1 acid glycoprotein (AGP). These proteins have been investigated as markers of various infectious diseases in small animals and the purpose of this review is to update the current knowledge about APPs in infectious diseases in dogs and cats.

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Concentrations of C-reactive protein, serum amyloid A, and haptoglobin in uterine arterial and peripheral blood in bitches with pyometra

Cited by 30 publications

References 26 publications

Effects of subclinical inflammation on C-reactive protein and haptoglobin levels as well as specific humoral immunity in dogs vaccinated against canine distemper and parvovirus

Effects of subclinical inflammation on C-reactive protein and haptoglobin levels as well as specific humoral immunity in dogs vaccinated against canine distemper and parvovirus

Hindlimb lameness and gait abnormalities in bitches with pyometra

Acute Phase Proteins as Markers of Infectious Diseases in small Animals / Proteini Akutne Faze Kao Markeri Infektivnih Bolesti Malih Životinja

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