Concentrations of Arsenic, Cadmium, Copper, Lead, Mercury, and Zinc in Human Placentas From Two Cities in Ukraine

Zadorozhnaja, Tamara D; Little, Ruth E.; Miller, Richard K.; Mendel, Nikola A; Taylor, Robert J.; Presley, B.J.; Gladen, Beth C.

doi:10.1080/00984100050136571

Cited by 66 publications

(17 citation statements)

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“…Hg concentrations varied widely; the highest were found in China (Shanghai) and Japan (Suzuki et al 1984; Tsuchiya et al 1984; Yang et al 1997), where the mean exceeded 50 ng/g, and in the Faroe Islands, with a median of approximately 90 ng/g (Needham et al 2011). In contrast, in Germany (Schramel et al 1988) and the Ukraine (Zadorozhnaja et al 2000), most samples were < LOD. Three studies also provided the proportion of organic to inorganic Hg (Capelli et al 1986; Soria et al 1992; Suzuki et al 1984).…”

Section: Resultsmentioning

confidence: 96%

“…Some researchers have reported an absence of association with drinking habits (Roels et al 1978), dental fillings (Hsu et al 2007), or tobacco abuse (Roels et al 1978). Some studies reported contradictory results related to residence in areas with industrial exposure (Karp and Robertson 1977; Zadorozhnaja et al 2000), whereas others found no differences between women living in rural and urban settings (Roels et al 1978; Truska et al 1989). Data on occupational exposures were equally sparse: One small study of Chinese women exposed to Hg at a lamp factory reported elevated placental levels (Yang et al 1997), yet we found no studies that had measured placental Hg levels among other occupationally exposed women, such as dentists or chloralkali plant workers.…”

Section: Resultsmentioning

confidence: 99%

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Mercury, Cadmium, and Lead Levels in Human Placenta: A Systematic Review

Esteban-Vasallo¹,

Aragonés

Pollán

et al. 2012

Environ Health Perspect

156

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Background: Placental tissue may furnish information on the exposure of both mother and fetus. Mercury (Hg), cadmium (Cd), and lead (Pb) are toxicants of interest in pregnancy because they are associated with alterations in child development.Objectives: The aim of this study was to summarize the available information regarding total Hg, Cd, and Pb levels in human placenta and possible related factors.Methods: We performed a systematic search of PubMed/MEDLINE, EMBASE, Lilacs, OSH, and Web of Science for original papers on total Hg, Cd, or Pb levels in human placenta that were published in English or Spanish (1976–2011). Data on study design, population characteristics, collection and analysis of placenta specimens, and main results were extracted using a standardized form.Results: We found a total of 79 papers (73 different studies). Hg, Cd, and Pb levels were reported in 24, 46, and 46 studies, respectively. Most studies included small convenience samples of healthy pregnant women. Studies were heterogeneous regarding populations selected, processing of specimens, and presentation of results. Hg concentrations > 50 ng/g were found in China (Shanghai), Japan, and the Faroe Islands. Cd levels ranged from 1.2 ng/g to 53 ng/g and were highest in the United States, Japan, and Eastern Europe. Pb showed the greatest variability, with levels ranging from 1.18 ng/g in China (Shanghai) to 500 ng/g in a polluted area of Poland.Conclusion: The use of the placenta as a biomarker to assess heavy metals exposure is not properly developed because of heterogeneity among the studies. International standardized protocols are needed to enhance comparability and increase the usefulness of this promising tissue in biomonitoring studies.

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Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Mercury, Cadmium, and Lead Levels in Human Placenta: A Systematic Review

Esteban-Vasallo¹,

Aragonés

Pollán

et al. 2012

Environ Health Perspect

156

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“…16, 23–29 Placental arsenic concentrations reported worldwide between 1976–2000 30 were on average 6 ng/g (range: 3–12 ng/g) (wet weight). More recently Jin et al 24 measured placental arsenic concentrations as part of a study of neural tube defects in a rural area of the Shanxi Province in northern China.…”

Section: Discussionmentioning

confidence: 99%

“…In a smaller study of arsenic concentrations in placental tissue from participants living close to a copper smelter in Bulgaria, 28 mean arsenic concentrations of 23 (± SD 21) ng/g were detected in placentas of participants living near the smelter (n=30), whereas an average of 7 (± SD 4) ng/g arsenic was measured in placental samples from those outside of the smelter area (N=15). Previous studies have been hindered by instrumental detection limits 23, 29 , whereas we had the advantage of using ICP-MS for ultra-trace arsenic detection. In light of our low detection limits and our findings of a range of placenta arsenic concentrations that extend below levels previously reported upwards to levels reported in industrially exposed communities, our study presents new information.…”

Section: Discussionmentioning

confidence: 99%

Placental arsenic concentrations in relation to both maternal and infant biomarkers of exposure in a US cohort

Punshon

Davis

Marsit

et al. 2015

J Expo Sci Environ Epidemiol

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Arsenic crosses the placenta and may have adverse consequences in utero and later in life. At present, little is known about arsenic concentrations in placenta and their relation to maternal and infant exposures particularly at common levels of exposure. We measured placenta arsenic in a US cohort potentially exposed via drinking water from private wells, and evaluated the relationships between placenta and maternal and infant biomarker arsenic concentrations. We measured total arsenic concentrations in placental samples from women enrolled in the New Hampshire Birth Cohort Study (N=766). We compared these data to maternal urinary arsenic (total arsenic and individual species) collected at approximately 24–28 week gestation, along with maternal post-partum toenails and infant toenails using non-parametric multivariate analysis of log10-transformed data. We also examined the association between placental arsenic and household drinking water arsenic. Placenta arsenic concentrations were related to arsenic concentrations in maternal urine (β 0.55, P value <0.0001), maternal (β 0.30, P value 0.0196) and infant toenails (β 0.40, P value 0.0293) and household drinking water (β 0.09, P value <0.0001). Thus, our data suggest that placenta arsenic concentrations reflect both maternal and infant exposures.

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“…Cd is absorbed into human body through food, drink, inhalation and smoking. In addition to kidney, liver and bone, placenta is the main target organ where Cd accumulates [1]. One of the major sources of Cd hazard is occupational exposure.…”

Section: Introductionmentioning

confidence: 99%

Down-regulation of ABCG2 and ABCB4 transporters in the placenta of rats exposed to cadmium

Liu

Zhou

et al. 2016

Oncotarget

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As a maternal and developmental toxicant, cadmium (Cd) possesses weak penetrability through the placental barrier. However, the underlying mechanism remains unclear. To gain insight into the protein molecules associated with Cd toxicity in placenta and explore their roles in Cd transportation, a reproductive animal experiment was carried out using Sprague-Dawley rats. We performed proteomic analysis of the placenta by Difference Gel Electrophoresis (DIGE) combined with Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Tandem Mass Spectroscopy (MALDI-TOF/TOF MS). The DIGE assay identified 15 protein spots that were differentially expressed with a greater than 1.5-fold change in placenta of Cd-treated rats compared to the control rats. Based on the expression patterns and biological functions of the proteins, we selected the ABCG2 and ABCB4 transporter proteins for further analysis. Western blot analysis showed that Cd exposure could down-regulate the expression of ABCG2 and ABCB4 in the placenta. There was a negative dose-response relationship between Cd exposure and the expression of ABCG2 or ABCB4 protein. These results indicated that down-regulation of ABCG2 and ABCB4 transporters may regulate Cd across through placenta and thus affect the in vivo toxic effect of Cd to fetus.

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Concentrations of Arsenic, Cadmium, Copper, Lead, Mercury, and Zinc in Human Placentas From Two Cities in Ukraine

Cited by 66 publications

References 0 publications

Mercury, Cadmium, and Lead Levels in Human Placenta: A Systematic Review

Mercury, Cadmium, and Lead Levels in Human Placenta: A Systematic Review

Placental arsenic concentrations in relation to both maternal and infant biomarkers of exposure in a US cohort

Down-regulation of ABCG2 and ABCB4 transporters in the placenta of rats exposed to cadmium

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