Concentrations and potential health hazards of organochlorine pesticides in shallow groundwater of Taihu Lake region, China

Wu, Chunfa; Luo, Yongming; Gui, Tong; Huang, Yujuan

doi:10.1016/j.scitotenv.2013.10.056

Cited by 79 publications

(27 citation statements)

References 46 publications

(47 reference statements)

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“…In air, total DDT and HCH levels ranged from 2.5 to 789.3 pg/m and 15 to 274.7 pg/m, respectively91011. In water, 52.5 and 43.7 ng/L of total DDT and HCH, respectively, was detected12. Dietary intake accounted for more than 90% of the OCPs burden in the general population13.…”

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confidence: 99%

Organochloride pesticides impaired mitochondrial function in hepatocytes and aggravated disorders of fatty acid metabolism

Liu

Wang

et al. 2017

Sci Rep

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p,p’-dichlorodiphenyldichloroethylene (p, p’-DDE) and β-hexachlorocyclohexane (β-HCH) were two predominant organochlorine pesticides (OCPs) metabolites in human body associated with disorders of fatty acid metabolism. However, the underlying mechanisms have not been fully clarified. In this study, adult male C57BL/6 mice were exposed to low dose of p, p’-DDE and β-HCH for 8 wk. OCPs accumulation in organs, hepatic fatty acid composition, tricarboxylic acid cycle (TCA) metabolites and other metabolite profiles were analyzed. Expression levels of genes involved in hepatic lipogenesis and β-oxidation were measured. Mitochondrial function was evaluated in HepG2 cells exposed to OCPs. High accumulation of p, p’-DDE and β-HCH was found in liver and damaged mitochondria was observed under electron microscopy. Expression of genes in fatty acid synthesis increased and that in mitochondrial fatty acid β-oxidation decreased in OCPs treatment groups. OCPs changed metabolite profiles in liver tissues, varied hepatic fatty acid compositions and levels of several TCA cycle metabolites. Furthermore, MitoTracker Green fluorescence, ATP levels, mitochondrial membrane potential and OCR decreased in HepG2 cells exposed to OCPs. In conclusion, chronic exposure to OCPs at doses equivalent to internal exposures in humans impaired mitochondrial function, decreased fatty acid β-oxidation and aggravated disorders of fatty acid metabolism.

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confidence: 99%

Organochloride pesticides impaired mitochondrial function in hepatocytes and aggravated disorders of fatty acid metabolism

Liu

Wang

et al. 2017

Sci Rep

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“…In Taihu Basin, total DDT concentrations of up to 1370 ng/l were detected in groundwater samples. Decomposition product concentrations exceeded the p,p 0 -DDT concentrations by orders of magnitude, giving evidence that the groundwater might had been historically polluted with DDT since 1980s (Li et al 2007;Wu et al 2014). Similar results were presented by Li et al (2013), who could demonstrate that the groundwater contamination in a shallow aquifer close to Taihu decreased with distance to the surface water body.…”

Section: Chinese Studies On Water Body Contamination From Pop Contamimentioning

confidence: 52%

Persistent organic pollutants contaminate Chinese water resources: overview of the current status, challenges and European strategies

et al. 2015

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“…Heptachlors were produced and used in China in the 1960s and 1970s as a pesticide primarily used against soil insects and termites (Wu et al 2014) as well as termite control in railway sleepers, and production was halted in 1978. In the present study, the content of heptachlor ranged from 4.30 to 13.95 ng g −1 with a mean value of 9.64 ng g −1 in historical cotton fields and 6.49-13.5 ng g −1 with an average of 10.3 ng g −1 in other fields.…”

Section: Composition and Source Identificationmentioning

confidence: 99%

Levels and patterns of organochlorine pesticides in agricultural soils in an area of extensive historical cotton cultivation in Henan province, China

Wang

Liu

et al. 2015

Environ Sci Pollut Res

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Organochlorine pesticides (OCPs) have attracted widespread concern because of their environmental persistence and toxicity. The historical influence of different agricultural land use types on soil concentrations of OCP residues was investigated by collecting a total of 52 surface soil samples from long-term cotton fields and fields with other crops in Lvdian township, Henan province, eastern central China. The concentration, composition, and possible sources of 16 OCPs were determined and a health risk assessment of these soils was conducted. Hexachlorocyclohexane (HCH), heptachlor, chlordane, and dichloro diphenyl trichloroethane plus its main metabolites (DDTs) were the most frequently detected OCPs with concentrations of 2.9-56.4 ng g −1 , 4.3-14.0 ng g −1 , 18.0-1254.4 ng g −1 , and below detection limit (BDL) −206.1 ng g −1 , respectively. Analysis of variance of p,p-DDE shows significant (P<0.05) differences while other OCPs show no significant differences between historical cotton fields and fields containing other crops. Compositional analysis suggests that the HCH is derived mainly from the use of lindane and that there are recent inputs. Analysis of variance and compositional analysis indicate that the p,p-DDE in surface soil from long-term cotton fields is derived mainly from the aerobic biodegradation of historical residues. The sum of carcinogenic risk values of OCPs for soil samples were found to be 1.58×10 −6 , posing a low cancer risk to the inhabitants of the region studied.

show abstract

Concentrations and potential health hazards of organochlorine pesticides in shallow groundwater of Taihu Lake region, China

Cited by 79 publications

References 46 publications

Organochloride pesticides impaired mitochondrial function in hepatocytes and aggravated disorders of fatty acid metabolism

Organochloride pesticides impaired mitochondrial function in hepatocytes and aggravated disorders of fatty acid metabolism

Persistent organic pollutants contaminate Chinese water resources: overview of the current status, challenges and European strategies

Levels and patterns of organochlorine pesticides in agricultural soils in an area of extensive historical cotton cultivation in Henan province, China

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