Concentrations and homologue patterns of SCCPs and MCCPs in the serum of the general population of adults in Hangzhou, China

Biomonitoring, exposure routes and risk assessment of chlorinated paraffins in humans: a mini-review

“…43 In our recent published article, we analyzed commercial CP products labeled as i-SCCP and i-M/LCCP purchased in 2019 using GC-NCI-MS, and the M/S ratios were 1.38 and 2.16 for i-SCCP and i- M/LCCP, respectively. 48 The M/S ratios for a commercial CP mixture CP-42 produced in China were also higher than 1, ranging from 1.17 to 1.98, but the ratios varied dramatically for different suppliers 57 for CP-52 and CP-70. More evidence was observed as the global production and emission of MCCPs were estimated to be higher than that of SCCPs by 2020.…”

“…42 The detection rates for both ∑SCCPs and ∑MCCPs were extremely high in multiple cities in China, including Beijing, Wuhan, Jinan, Guangzhou and Hangzhou, up to 100%. 36,37,44,46–48 The sampling period for these studies from China ranges from 2012 to 2020 (summarized in Table 1), which suggests that the detection rates were more likely to be influenced by geographical locations. However, more solid evidence is required such as multi-center studies that include blood samples from different countries and sampling periods.…”

“…44 In our recent investigation, the median ∑SCCP and ∑MCCP levels are one order of magnitude lower in Hangzhou, China. 48 Based on existing evidence, the general population in China bore higher serum CP burden. It is possibly because China has been producing CPs since 1950s and became the primary producer and consumer of CPs worldwide over the last few decades.…”

“…According to the length of the carbon chain in the SCCPs, a regional difference was observed. ΣC 10 was dominant in the Czech Republic, 41 Korea, Japan 51 and multiple cities/provinces in China, including Hangzhou, 48 Dalian, 40 Beijing, 37 Wuhan, 36 Mianyang, 50 and Henan. 59 ΣC 11 wwas found to be dominant in the serum samples collected in Northern Norway 42 and Australia, 43 while ΣC 13 accounted for more than 40% in Jinan; 44,46,47 and Shenzhen, 49 China.…”