We relate non integer powers L s , s > 0 of a given (unbounded) positive selfadjoint operator L in a real separable Hilbert space H with a certain differential operator of order 2⌈s⌉, acting on even curves R → H. This extends the results by Caffarelli-Silvestre and Stinga-Torrea regarding the characterization of fractional powers of differential operators via an extension problem.