Concentration of Substance P, Neurokinin A, Calcitonin Gene-related Peptide, Neuropeptide Y and Vasoactive Intestinal Polypeptide in Synovial Fluid from Knee Joints in Patients Suffering from Rheumatoid Arthritis

Larsson, Johan; Ekblom, A.; Henriksson, K.; Lundeberg, Thomas; Theodorsson, Elvar

doi:10.3109/03009749109096808

Cited by 125 publications

(56 citation statements)

References 43 publications

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“…Neuropeptides have the potential to contribute to inflammatory disease as the "neurogenic component" via a variety of mechanisms (10). Levels of neuropeptides have been shown to be increased in samples of synovial fluid from patients with rheumatoid arthritis (11), and the ligation of sensory nerves in experimental joint inflammation is associated with a beneficial effect (12), providing evidence for involvement of sensory nerve activation in arthritis. Indeed, continued topical treatment with capsaicin has been shown to be beneficial in patients with hand osteoarthritis (13), and capsaicin creams are marketed for the alleviation of pain in diseases including both osteoarthritis and rheumatoid arthritis (14).…”

Section: 05) In Trpv1mentioning

confidence: 99%

Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation

Keeble¹,

Russell²,

Curtis³

et al. 2005

Arthritis & Rheumatism

154

117

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Objective. To investigate the endogenous involvement of transient receptor potential vanilloid 1 (TRPV1) in a model of knee joint inflammation in the mouse.Methods. Following characterization of wild-type (WT) and TRPV1-knockout mice, inflammation was induced via intraarticular (IA) injection of Freund's complete adjuvant (CFA). Knee swelling was assessed as diameter, and inflammatory heat hyperalgesia was determined using the Hargreaves technique, for up to 3 weeks. At 18 hours, acute hyperpermeability was measured with 125 I-albumin, and cytokines and myeloperoxidase activity, a marker of neutrophils, were assayed in synovial fluid extracts. The possibility that exogenous tumor necrosis factor ␣ (TNF␣) was involved in influencing TRPV1 activation was investigated in separate experiments.Results. Increased levels of knee swelling, hyperpermeability, leukocyte accumulation, and TNF␣ were found in WT mice 18 hours after IA CFA treatment compared with saline treatment. Significantly less knee swelling and hyperpermeability were found in TRPV1 ؊/؊ mice, but leukocyte accumulation and TNF␣ levels were similar in WT and TRPV1 ؊/؊ mice. Knee swelling in response to CFA remained significantly higher for a longer period in WT mice compared with TRPV1 ؊/؊ mice, with thermal hyperalgesic sensitivity observed at 24 hours and at 1 week in WT, but not TRPV1 ؊/؊ , mice. Knee swelling was attenuated (P < 0.05) in TRPV1 ؊/؊ compared with WT mice 4 hours after IA administration of TNF␣.Conclusion. Our findings indicate that TRPV1 has a role in acute and chronic inflammation in the mouse knee joint. Thus, selective antagonism of TRPV1 should be considered as a potential target for treatment of acute and chronic joint inflammation.

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Section: 05) In Trpv1mentioning

confidence: 99%

Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation

Keeble¹,

Russell²,

Curtis³

et al. 2005

Arthritis & Rheumatism

154

117

View full text Add to dashboard Cite

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“…37 In patients with rheumatoid arthritis, and in rat adjuvent arthritis, increased expression of sensory neuropeptides has been reported in the synovial membrane and synovial fluid. [38][39][40][41] Sensory neuropeptides have also been implicated in vasodilatation. 42,43 In our study, CGRP-positive fibres were found mostly around the blood vessels.…”

Section: Discussionmentioning

confidence: 99%

Sensory nerves in the interface membrane of aseptic loose hip prostheses

Ahmed

Bergström

Lundblad

et al. 1998

The Journal of Bone and Joint Surgery. British volume

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We studied the presence of sensory nerves by immunohistochemistry in the interface membranes of hip prostheses after aseptic loosening. Substance P (SP), neurokinin A (NKA) and calcitonin gene-related peptide (CGRP) were analysed as was protein gene product (PGP) 9.5, a general marker for nerve fibres.We identified nerve fibres in all samples but differences in their density were found. SP-and NKA-positive fibres were predominantly non-vascular, forming varicose nerve terminals. CGRP-immunoreactive nerve fibres with varicose terminals were seen mostly close to blood vessels, but also as free nerve endings.Sensory neuropeptides participate not only in nociception but also stimulate immune cells to release cytokines. The presence of sensory nerves in the interface membrane may reflect a pathophysiological response contributing to the aseptic loosening of hip prostheses.J Bone Joint Surg [Br] 1998;80-B:151-5.

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“…In addition to expanding the CD4 ϩ CD25 AM is structurally related to CGRP and is an endogenous ligand of the calcitonin-related-like receptor (CRLR). 5 Although, increased CGRP levels have been found in patients and animals with arthritis, 25,26 and therefore, CGRP has been suspected as immunomodulatory factor, 27 CGRP does not efficiently down-regulate the synovial inflammatory response and fails to prevent CIA ( Figures 1C and 2D). 28 The difference in effectiveness between AM and CGRP could reside in the differential binding of both peptides to different binding complexes, which are formed by the CRLR and various receptor activity-modifying proteins (RAMP1, RAMP2, and RAMP3).…”

Section: Cd4mentioning

confidence: 99%

Adrenomedullin Protects from Experimental Arthritis by Down-Regulating Inflammation and Th1 Response and Inducing Regulatory T Cells

González‐Rey

Chorny

O’Valle

et al. 2007

The American Journal of Pathology

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Rheumatoid arthritis is a chronic autoimmune disease of unknown etiology characterized by chronic inflammation in the joints and subsequent destruction of the cartilage and bone. The present study proposes a new strategy for the treatment of arthritis: the administration of the immunomodulatory neuropeptide adrenomedullin. Treatment with adrenomedullin significantly reduced incidence and severity of collagen-induced arthritis, an experimental model of rheumatoid arthritis, completely abrogating joint swelling and destruction of cartilage and bone. The therapeutic effect of adrenomedullin was associated with a striking reduction of the two deleterious components of the disease, ie, the Th1-driven autoimmune and inflammatory responses. Adrenomedullin also induced the generation and/or activation of efficient CD4 ؉ CD25 ؉ regulatory T cells in arthritis with capacity to suppress autoreactive response and restore immune tolerance, which could play a pivotal role in the therapeutic effect of adrenomedullin on experimental arthritis contributing to the restoration of immune tolerance.

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Concentration of Substance P, Neurokinin A, Calcitonin Gene-related Peptide, Neuropeptide Y and Vasoactive Intestinal Polypeptide in Synovial Fluid from Knee Joints in Patients Suffering from Rheumatoid Arthritis

Cited by 125 publications

References 43 publications

Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation

Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation

Sensory nerves in the interface membrane of aseptic loose hip prostheses

Adrenomedullin Protects from Experimental Arthritis by Down-Regulating Inflammation and Th1 Response and Inducing Regulatory T Cells

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