Concentration of Serum Protein-Bound Iodine in Normal Men 12

The Serum Protein‐bound Iodine Level in Acute Myocardial Infarction

“…These limits were determined from a study of 1,800 clinically healthy subjects by the commercial company that supplies the materials and the method for the determination (15). This range was further corroborated by evaluation of the literature reports of determinations on the blood of euthyroid persons (16–32).…”

“…The mean and range of PBI values found in this series of patients with myocardial infarction were lower than those in apparently healthy subjects (Table 5) (16–32). Half of the patients with acute myocardial infarction had PBI values less than 4.4 μg per 100 ml and 39.7 per cent had values less than 4.0 μg per 100 ml, indicating that in a surprisingly high percentage of them the thyroid gland was functioning marginally or submarginally.…”

“…Even assuming a laboratory difference of error of 1.0 μg per 100 ml in each case and that each error resulted in a lower reading rather than in randomly distributed higher and lower readings (both of which are highly unlikely), and further assuming that each reading needed a correction increase of 1 μg per 100 ml, there would still be a considerable number (23.3 per cent) of myocardial infarction patients (Table 3) who had marginal or submarginal functioning of their thyroid glands as indicated by PBI levels less than 4.5 μg per 100 ml even with the correction. Therefore, it is most improbable that laboratory error or differences between laboratories could account fully for the high percentage of low PBI levels found in this study. Myocardial infarction patients are in an older age group, and some workers have reported finding lower PBI values with age (32–33). However, this is controversial and most reports state that no change was found in the PBI level with age alone (34–38).…”

The Thyroid and Aging*

“…and was thought to be of no significance, though no statistical comparisons were made for either group and statistics later calculated for the males showed the difference to be significant at only the 5 per cent level (20). In another study there was a slight decrease in PBI concentration between young (18–25 years) and middle‐aged (45–56 years) men (21). On the other hand, the data of Soley and Dailey (22) indicate no change in the PBI concentration from the first to the eighth decades, and the data of other studies concur with this conclusion (11, 13, 15, 23).…”

Biochemical Genetics and Its Human Implications

“…The existence of blood groups has been recognized for over fifty years, and it is now well established th a t the individuals are distinctive with respect to the content of immune substances in their blood. The protein-bound iodine of the blood varies from individual to individual over at least a 5-to 10-fold range [9,10,11], and remains relatively constant for each individual [12]. The bloods of different individuals vary in their content of various types of lipides; and in the case of cholesterol, lipide phosphorus, and titrated fatty acids, at least, the individual differences are persistent [13].…”