Concentration of Procaine in the Cerebrospinal Fluid of the Human Being After Subarachnoid Injection

Studies With a Radioactive Spinal Anaesthetic

“…From thle Departments of Pharmacology and Anatomy, Manchester University (Received October 7, 1949) The need for information about the fate of a spinal anaesthetic after its introduction into the spinal theca was early recognized (Miller, 1901), but many years elapsed before the problem was seriously studied by a number of workers, including Stout (1929), Kustner and Eissner (1930), Koster et al (1936Koster et al ( , 1938Koster et al ( , 1939, Bullock and Macdonald (1938), and Shields (1942). In the main these workers agreed that after the intrathecal injection of procaine there was a rapid initial drop in local concentration with a subsequent period of gradual decrement.…”