Concentration of mercury species in hair, blood and urine of individuals occupationally exposed to gaseous elemental mercury in Asturias (Spain) and its comparison with individuals from a control group formed by close relatives

Queipo-Abad, Silvia; González, Pablo Rodríguez; Martínez‐Morillo, Eduardo; Davis, William C.; Alonso, J. Ignacio García

doi:10.1016/j.scitotenv.2019.03.367

Cited by 17 publications

(3 citation statements)

References 62 publications

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“…Post-shift urinary excretion data from di(2-ethylhexyl) phthalate (DEHP) and phthalic acid were taken from an exposure study among workers of a chemical plant producing DEHP from phthalic acid and 2-ethylhexanol [ 55 ]. For these data and other endpoints like mercury in hair [ 54 ] the required number of exposed workers and controls are similar to those indicated for welders. Overall, the target population size for this project, assuming three to four companies from two to four categories of e-waste processing, is presented in Table 7 .…”

Section: Study Populationmentioning

confidence: 60%

HBM4EU Occupational Biomonitoring Study on e-Waste—Study Protocol

Scheepers

Duca

Galea

et al. 2021

IJERPH

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Workers involved in the processing of electronic waste (e-waste) are potentially exposed to toxic chemicals. If exposure occurs, this may result in uptake and potential adverse health effects. Thus, exposure surveillance is an important requirement for health risk management and prevention of occupational disease. Human biomonitoring by measurement of specific biomarkers in body fluids is considered as an effective method of exposure surveillance. The aim of this study is to investigate the internal exposure of workers processing e-waste using a human biomonitoring approach, which will stimulate improved work practices and contribute to raising awareness of potential hazards. This exploratory study in occupational exposures in e-waste processing is part of the European Human Biomonitoring Initiative (HBM4EU). Here we present a study protocol using a cross sectional survey design to study worker’s exposures and compare these to the exposure of subjects preferably employed in the same company but with no known exposure to industrial recycling of e-waste. The present study protocol will be applied in six to eight European countries to ensure standardised data collection. The target population size is 300 exposed and 150 controls. Biomarkers of exposure for the following chemicals will be used: chromium, cadmium and lead in blood and urine; brominated flame retardants and polychlorobiphenyls in blood; mercury, organophosphate flame retardants and phthalates in urine, and chromium, cadmium, lead and mercury in hair. In addition, the following effect biomarkers will be studied: micronuclei, epigenetic, oxidative stress, inflammatory markers and telomere length in blood and metabolomics in urine. Occupational hygiene sampling methods (airborne and settled dust, silicon wristbands and handwipes) and contextual information will be collected to facilitate the interpretation of the biomarker results and discuss exposure mitigating interventions to further reduce exposures if needed. This study protocol can be adapted to future European-wide occupational studies.

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Section: Study Populationmentioning

confidence: 60%

HBM4EU Occupational Biomonitoring Study on e-Waste—Study Protocol

Scheepers

Duca

Galea

et al. 2021

IJERPH

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“…ASGM has heavily elevated the Hg levels in the environment near mining sites and caused significant health impacts on miners and nearby residents ( Gerson et al., 2022 ; Basu et al., 2015 ; Queipo-Abad et al., 2019 ; Gibb and O’Leary, 2014 ; Dong et al., 2015 ; Rajaee et al., 2015 ). Due to the long lifetime of Hg in the atmosphere (∼0.5–1 year), the atmospheric emissions from ASGM can also be transported globally and become part of its global biogeochemical cycles ( Strode et al., 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Global health impact of atmospheric mercury emissions from artisanal and small-scale gold mining

Pang¹,

Gu²,

Wang³

2022

iScience

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“…However, recent studies have reported that the human hair displays significant correlations between the MMHg fraction and δ 202 Hg THg or Δ 199 Hg THg , which suggests distinct isotope properties between the IHg and MMHg fractions. Therefore, using the isotope values of THg to quantify the MMHg exposure sources contains large uncertainties since the human hair, fishery foods, and rice occasionally present low MMHg/THg values, ,− and the mechanisms that are behind the biogeochemical behaviors of different Hg species are poorly understood . Although gas chromatography (GC) has been used for the separation and identification of chemical Hg compounds, this online method may cause variations of up to 0.5‰ in δ 202 Hg, which result in low precision when analyzing the MMHg isotope values. , Recently, a selective extraction method (SEM) has been developed for compound-specific stable isotope analysis (CSIA), which can extract MMHg from aqueous biological samples without GC separation and offers high precision for the MMHg isotope values .…”

Section: Introductionmentioning

confidence: 99%

Compound-Specific Stable Isotope Analysis Provides New Insights for Tracking Human Monomethylmercury Exposure Sources

Yang

Wang

Qin

et al. 2021

Environ. Sci. Technol.

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Monomethylmercury (MMHg) exposure can induce adverse neurodevelopmental effects in humans and is a global environmental health concern. Human exposure to MMHg occurs predominately through the consumption of fishery foods and rice in Asia, but it is challenging to quantify these two exposure sources. Here, we innovatively utilized MMHg compound-specific stable isotope analyses (MMHg-CSIA) of the hair to quantify the human MMHg sources in coastal and inland areas, where fishery foods and rice are routinely consumed. Our data showed that the fishery foods and rice end members had distinct Δ199HgMMHg values in both coastal and inland areas. The Δ199HgMMHg values of the human hair were comparable to those of fishery foods but not those of rice. Positive shifts in the δ202HgMMHg values of the hair from diet were observed in the study areas. Additionally, significant differences in δ202Hg versus Δ199Hg were detected between MMHg and inorganic Hg (IHg) in the human hair but not in fishery foods and rice. A binary mixing model was developed to estimate the human MMHg exposures from fishery foods and rice using Δ199HgMMHg data. The model results suggested that human MMHg exposures were dominated (>80%) by fishery food consumption and were less affected by rice consumption in both the coastal and inland areas. This study demonstrated that the MMHg-CSIA method can provide unique information for tracking human MMHg exposure sources by excluding the deviations from dietary surveys, individual MMHg absorption/demethylation efficiencies, and the confounding effects of IHg.

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Concentration of mercury species in hair, blood and urine of individuals occupationally exposed to gaseous elemental mercury in Asturias (Spain) and its comparison with individuals from a control group formed by close relatives

Cited by 17 publications

References 62 publications

HBM4EU Occupational Biomonitoring Study on e-Waste—Study Protocol

HBM4EU Occupational Biomonitoring Study on e-Waste—Study Protocol

Global health impact of atmospheric mercury emissions from artisanal and small-scale gold mining

Compound-Specific Stable Isotope Analysis Provides New Insights for Tracking Human Monomethylmercury Exposure Sources

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