Concentration of Luteinizing and Follicle-Stimulating Hormones in Peripheral and Ovarian Venous Plasma<sup>1</sup>

Llerena, Luis; Guevara, Amelia; Lobotsky, Julia; Lloyd, Charles W.; Weisz, Judith; Pupkin, M; Zañartu, J; J, Puga

doi:10.1210/jcem-29-8-1083

Cited by 13 publications

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“…A major effect by this type of stress can be ruled out by the study of Eik-Nes (12) who did not detect an acute influence of intravenous ACTH on testosterone production in the dog. In the monkey, serum levels of gonadotropin are not modified by surgery (13). On the basis of our data on the peripheral plasma concentrations of testosterone in dogs submitted to a laparotomy and in animals which did not, we can conclude that surgery itself has little effect on the production rate of T in the canine species.…”

Section: Discussionmentioning

confidence: 59%

Studies on the Dynamics of Plasma Androgens and on the Origin of Dihydrotestosterone in Dogs

et al. 1972

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Testosterone and androstenedione dynamics were studied with a constant infusion technique in adult male dogs. The metabolic clearance rate (1370 ± 660 I/day) and blood production rate (1.5 ± 0.7 mg/day) of testosterone were similar to the metabolic clearance rate (1870 ± 760 I/day) and blood production rate (1.2 ± 0.3 mg/day) of androstenedione. Plasma concentrations of testosterone and androstenedione were respectively 115 ± 46 ng/100 ml and 66 ± 15 ng/100 ml. The conversion of these two prehormones to dihydrotestosterone was studied; respectively, 8.6 ± 2.2 and 1.8 ± 1.1% of plasma testosterone and androstenedione were converted to plasma dihydrotestosterone. In addition, testosterone and dihydrotestosterone were simultaneously measured in peripheral, adrenal and spermatic vein plasma. The concentration of testosterone at these three different sites was 116 ± 18, 98 ± 41 and 6620 ± 2100 ng/100 ml while the concentration of dihydrotestosterone was 34 ± 16, 79 d= 24 and 1710 ± 780 ng/100 ml. From these data, it is concluded that about 1/3 of plasma dihydrotestosterone is derived from plasma precursors while the rest arises from glandular secretion, mainly the testes. (Endocrinology 9 1 : 556, 1972)

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Section: Discussionmentioning

confidence: 59%

Studies on the Dynamics of Plasma Androgens and on the Origin of Dihydrotestosterone in Dogs

et al. 1972

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“…Since only one pair of specimens of blood was obtained from one subject, it is impossible to recognize positively the preovulatory peak of LH. However, subjects 23, 12, 26 and 7 were those who had the high LH levels [see previous publication describing ovarian and peripheral plasma gonadotrophins (16)]. This finding, in addition to the menstrual history, endometrial biopsy dating and ovarian morphology, would seem reasonably good evidence that these subjects were operated on close to the time of ovulation.…”

Section: Resultsmentioning

confidence: 65%

“…In addition, pregnenolone, 4 17a-hydroxy progesterone (17-OHP), 20a-dihydroprogesterone (20-OHP) and dehydroepiandrosterone (DHEA) were measured in ovarian venous plasma only. The concentrations of FSH and LH in the peripheral and ovarian venous plasma of the normal subjects in this study as well as of women using steroid contraceptives have been reported (16).…”

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confidence: 59%

“…However, Knobil et al (25) have shown that single or repeated laparotomies and examination of the ovaries do not alter subsequent function of the corpus luteum in the monkey. Gonadotrophin levels in plasma do not change during surgery (16). It is impossible to rule out a short-term alteration in steroid secretion or changes in ovarian blood flow which could alter the concentration of steroids during the sampling of blood from the ovary.…”

Section: Resultsmentioning

confidence: 99%

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Concentration of Unconjugated Estrogens, Androgens and Gestagens in Ovarian and Peripheral Venous Plasma of Women: The Normal Menstrual Cycle¹

Lloyd

Lobotsky

Baird

et al. 1971

The Journal of Clinical Endocrinology & Metabolism

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The concentrations of unconjugated estrone (Ei), estradiol (E 2 ), testosterone (T), androstenedione (A) and progesterone (P) were measured in peripheral and ovarian venous plasma collected from 18 healthy women on days 7-30 of the menstrual cycle at the time of elective tubal ligation. An additional 4 steroids, pregnenolone, 17a-hydroxyprogesterone (17-OHP), 20«-dihydroxyprogesterone (20-OHP) and dehydroepiandrosterone (DHEA), were measured in ovarian venous plasma. In 2 subjects, one in the follicular phase and one in the luteal phase, blood was obtained from both ovaries. There was evidence of secretion by the ovary of all the steroids measured. Of the Cis and Cio steroids, E2 and A, respectively, were secreted by the ovary in largest amounts. There was a wide range of concentration of each steroid in ovarian venous plasma collected at the same time of the cycle from different subjects. High concentrations of E 2 were associated with high levels of Ei, T and A. DHEA appeared to be higher in plasma from the less actively secreting ovary. Equally high values of all these steroids were found in specimens from both phases of the cycle. There clearly was secretion of progesterone in the luteal phase from the ovary containing the corpus luteum. In the subject where bilateral sampling was performed, the ovary that did not contain the corpus luteum secreted lesser, though still significant, amounts of P than the one containing the corpus luteum. In the follicular phase, there was a suggestion of secretion of P in 2 cases. In 3 of 4 subjects in the follicular phase in which 17-OHP was measured, it was increased; in one of these, 17-OHP was higher in blood from the ovary secreting the smaller amount of e3trogen. In the luteal phase, high levels of 17-OHP were found in some subjects. The relationship between 17-OHP and P or E 2 was not consistent. The range of concentrations of all the steroids in the peripheral plasma was much less than in the ovarian plasma. The ratios of A/T and E2/Ei in ovarian vein plasma were 4-6 times higher than in peripheral vein plasma. (J Clin Endocr 32: 155, 1971) M OST of the concepts concerning the endocrine events in the menstrual cycle have been deiived from observations

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“…Smeaton & Robertson (1971) (Ginther, 1971) or indirectly by interfering with gonadotrophic hormones in the ovary (Llerena, Guevara, Lobotsky, Lloyd & Weisz, 1969). The end of the first growth wave occurs when the progesterone level has reached its maximum (Thorburn,Bassett & Smith,439 1969; Stabenfelt, Holt & Ewing, 1969 (Moore, Barrett, Brown, Schindler, Smith & Smyth, 1969).…”

Section: Introductionmentioning

confidence: 99%

Qualitative and Quantitative Micromorphological Investigations of the Tertiary Follicle Population During the Oestrous Cycle in Sheep

Brand¹,

Jong²

1973

Reproduction

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Concentration of Luteinizing and Follicle-Stimulating Hormones in Peripheral and Ovarian Venous Plasma¹

Cited by 13 publications

References 0 publications

Studies on the Dynamics of Plasma Androgens and on the Origin of Dihydrotestosterone in Dogs

Studies on the Dynamics of Plasma Androgens and on the Origin of Dihydrotestosterone in Dogs

Concentration of Unconjugated Estrogens, Androgens and Gestagens in Ovarian and Peripheral Venous Plasma of Women: The Normal Menstrual Cycle¹

Qualitative and Quantitative Micromorphological Investigations of the Tertiary Follicle Population During the Oestrous Cycle in Sheep

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Concentration of Luteinizing and Follicle-Stimulating Hormones in Peripheral and Ovarian Venous Plasma1

Cited by 13 publications

References 0 publications

Studies on the Dynamics of Plasma Androgens and on the Origin of Dihydrotestosterone in Dogs

Studies on the Dynamics of Plasma Androgens and on the Origin of Dihydrotestosterone in Dogs

Concentration of Unconjugated Estrogens, Androgens and Gestagens in Ovarian and Peripheral Venous Plasma of Women: The Normal Menstrual Cycle1

Qualitative and Quantitative Micromorphological Investigations of the Tertiary Follicle Population During the Oestrous Cycle in Sheep

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Concentration of Luteinizing and Follicle-Stimulating Hormones in Peripheral and Ovarian Venous Plasma¹

Concentration of Unconjugated Estrogens, Androgens and Gestagens in Ovarian and Peripheral Venous Plasma of Women: The Normal Menstrual Cycle¹