Objectives: Heavy metals ingested through the consumption of aquatic products can accumulate in the human body over the long-term and cause various health problems. This study aims to present comprehensive data on the amount of heavy metals found in fish and shellfish in Korea using a systematic review of studies that report on that issue. Methods: The study used the following databases: PubMed, Korean Studies Information Service System, and Research Information Sharing Service. The search terms for PubMed included fish OR shellfish OR seafood AND mercury OR cadmium OR lead OR heavy metal AND Korea. The search terms for Korean Studies Information Service System and Research Information Sharing Service included eoryu sueun, eoryu kadeumyum, eoryu nab, eoryu jung-geumsog, paeryu sueun, paeryu kadeumyum, paeryu nab, paeryu jung-geumsog, eopaeryu sueun, eopaeryu kadeumyum, eopaeryu nab, and eopaeryu jung-geumsog. Results: A total of 32 articles were selected for review. The total mercury, lead, and cadmium concentrations in fish and shellfish reported in each of the articles are summarized, as are the species of fish and shellfish with relatively high concentrations of heavy metals. Total mercury concentrations tended to be higher in predatory fish species, such as sharks, billfishes, and tuna, while lead and cadmium concentrations tended to be higher in shellfish. Conclusion: This paper is the first to report a comprehensive summary of the concentrations of heavy metals in fish and shellfish. This data could be used as evidence to protect Koreans from exposure to heavy metals due to the consumption of highly polluted aquatic products. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. � ��� 1 2
ResultsAfter removing duplicate records, 398 bibliographic records were identified. Among these records, 345 articles did not meet the inclusion criteria at the first screening, 53 full-text articles were selected for full-text screening, and 32 articles were obtained and screened. Information about the searching and screening process, and the study inclusion criteria are summarized in the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow diagram presented in Fig. 1.Studies that examined the concentrations of three heavy metals, Hg, Pb, and Cd, in fish and shellfish in Korea are summarized in Supplementary Table 1. The number of samples analyzed, and the mean, standard deviation, and minimum and maximum values of the total Hg, Pb, and Cd concentrations in fish and shellfish reported in the selected literature are summarized in Supplementary Tables 2, 3, and 4, respectively. Of the 32 articles that reported on the concentrations of heavy metals in fish and shellfish, 15 reported Hg concentrations [10-24], 12 reported heavy metal concentrations for...