Concentration of Diphtheria Antitoxin in Cord Blood and Rate of Loss in Babies

Immunochemical Studies of Human Serum Gamma Globulins*

“…The mean biologic half-life of parenterally administered gamma globulin, established by the im-munochemical method, reveals a value which is comparable to that reported by Bruton, Apt, Gitlin and Janeway (11) (23)(24)(25).…”

Demonstration of an Inhibitor of the Muller Phenomenon in Human Sera: Its Identification as Antistaphylokinase*

“…Indeed, the inhibitor titer was one dilution higher in the cord serum in a majority of maternal-cord pairs. A finding of slightly higher antibody titers in cord sera than in maternal sera has been reported for other bacterial antibodies (21,22). Among adults with staphylococcal lesions (chiefly wound infections), the distribution of inhibitor titers was somewhat higher than in normal human adults.…”

Evolution of Titre of Serum IgG in Newborn

“…In 1951 Wiener [38] studied the fall of anti-Rh antibodies in two Rh-negative children: the first sample taken on the day of birth, the second on the 19th day for one child and the 93rd day for the other. Half-life was estimated at 30 days, a figure similar to that of Barr et al [3]. Wiener [38], however, believed that this result was applicable from the first days of life and questioned the validity of the Barr et al [3] figures.…”

“…Half-life was estimated at 30 days, a figure similar to that of Barr et al [3]. Wiener [38], however, believed that this result was applicable from the first days of life and questioned the validity of the Barr et al [3] figures.…”

“…Barr et al [3] found a distinctly higher concentration of diphtheria antitoxin in newborn than in the mother, as early as 1949. They observed a rapid fall during the first days following birth and evaluated the half-life of the antitoxin at about 4.5 weeks later on.…”