Concentration of circulating tumour DNA in patients with metastatic gastric cancer and its prognostic significance

Karamitrousis, Evangelos; Balgkouranidou, Ioanna; Xenidis, Nikolaos; Amarantidis, Kyriakos; Biziota, Eirini; Koukaki, Triantafyllia; Kakolyris, Stylianos

doi:10.2478/fco-2021-0010

Forum of Clinical Oncology

2021

DOI: 10.2478/fco-2021-0010

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Concentration of circulating tumour DNA in patients with metastatic gastric cancer and its prognostic significance

Evangelos Karamitrousis

Ioanna Balgkouranidou

Nikolaos Xenidis

et al.

Abstract: Gastric cancer is one of the most common cancers worldwide. The amount of cell-free DNA (cfDNA) in the blood of patients with gastric cancer was found to be higher than that of healthy controls (69.1 ng/μL vs. 34.8 ng/μL). Patients with cfDNA ≤ 50 ng/μL were found to have an increased overall survival (OS) and progression free survival (PFS) than in patients with cfDNA > 50 ng/μL.

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“…In the current issue of the journal, articles report on some very interesting areas of research, including the prognostic significance of cell-free DNA in gastric cancer [13] , the relationship between sialic acids and cancer [14] , the development of bioflavonoid-containing chemotherapy delivery systems [15] , and more. We believe the articles will be of great interest and will provide readers the opportunity to connect with novel areas of cancer diagnosis and therapy.…”

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confidence: 99%

Epigenetics and cancer – A dependence relationship

Karamitrousis

Liontos

Tsoukalas

2021

Forum of Clinical Oncology

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mentioning

confidence: 99%

Epigenetics and cancer – A dependence relationship

Karamitrousis

Liontos

Tsoukalas

2021

Forum of Clinical Oncology

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Survival rate and prognostic factors of oral squamous cell carcinoma in Indonesia: A single-center retrospective study

Kartini

Kurnia

Putri

et al. 2022

Forum of Clinical Oncology

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Background Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy in Asia. Most patients in Cipto Mangunkusumo Hospital have been diagnosed with an advanced stage. There had not been any survival study for OSCC in Indonesia. This study aimed to investigate the survival rate and prognostic factors of OSCC in Cipto Mangunkusumo Hospital. Methods A retrospective cohort study was conducted on OSCC patients diagnosed and treated in Cipto Mangunkusumo Hospital from 2014 to 2018. Data regarding age, gender, site of the primary lesion, clinical stage of the disease, tumor differentiation, invasion, and surgical margins were collected. The main outcomes measured were overall survival (OS) and disease-specific survival (DSS). The predictors of survival were then determined. Result 169 patients were included. The majority of patients were male (51.5%) and above 50 years old (55.6%). The most prevalent tumor site was the tongue (72.8%) followed by buccal mucosa (13%). The majority (82.2%) of patients had advanced (clinical stage IV) disease at diagnosis. A smaller majority of patients had a well-differentiated tumor (60.4%) and a low-grade tumor (53.8%). The worst one-year and two-year overall survival rates were found in the stage IV group (53.5% and 37.5%, respectively). The disease-specific survival rate was 66.9%. Conclusion The one-year and two-year overall survival rates of OSCC in Cipto Mangunkusumo Hospital were 58.6% and 43.1%. Moreover, clinical stage, tumor size, and lymph node involvement were the most significant prognostic factors for OSCC.

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Concentration of circulating tumour DNA in patients with metastatic gastric cancer and its prognostic significance

Cited by 2 publications

References 13 publications

Epigenetics and cancer – A dependence relationship

Epigenetics and cancer – A dependence relationship

Survival rate and prognostic factors of oral squamous cell carcinoma in Indonesia: A single-center retrospective study

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