Concentration of blood and seminal plasma elements and their relationships with semen parameters in men with spinal cord injury

Salsabili, Nasser; Mehrsai, Abdolrasoul; Jalaie, Shohreh

doi:10.1111/j.1439-0272.2008.00885.x

Cited by 21 publications

(10 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported in some studies that SCI accompany with poor semen quality, specially decreased sperm motility, morphology, and viability. [31][32][33][34] With regard to sperm concentration, our result was in contrast with Salsabili et al 33 (2009) study in which a significant elevation was found in the SCI group compared with fertile men. However, in another studies, sperm count had been remained in normal range after SCI.…”

Section: Discussioncontrasting

confidence: 99%

“…16,36 A well-known potential source of ROS production in semen is activated leukocytes 28,37 which are significantly increased among patients with SCI. 33,34,38 It is shown that high levels of oxidative stress in the semen of patients with SCI are negatively related to both semen parameters and sperm DNA integrity. 37 We should consider that each 25% increase of seminal ROS induces 10% increase in sperm DNA fragmentation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sperm chromatin condensation, DNA integrity, and apoptosis in men with spinal cord injury

Talebi

Khalili

Vahidi

et al. 2013

The Journal of Spinal Cord Medicine

View full text Add to dashboard Cite

Objectives: To evaluate the effect of cord injury on (1) sperm parameters and (2) DNA chromatin status. Design: Case-control study. Setting: Data were collected from men referred to Research and Clinical Center for Infertility, Yazd, Iran. Participants: Thirty infertile men with the presence of any level of spinal cord injury (SCI) were compared with 30 healthy donors with definite fertility and normal sperm parameters. Interventions: Not applicable. Outcome measures: Sperm chromatin integrity was assessed using aniline blue (AB), chromomycin A3 (CMA3), toluidine blue (TB), and acridine orange (AO) assays. The rate of apoptotic spermatozoa was evaluated with terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling (TUNEL) staining. Results: Sperm concentration, motility, and morphology in men with SCI were significantly decreased compared with control group (P < 0.05). In addition, with regard to cytochemical staining and TUNEL test, the rate of reacted spermatozoa was increased significantly in SCI group when compared with the controls (P < 0.05). The majority of AB, TB, AO, and CMA3-reacted spermatozoa were higher than the "cut-off" value in men with SCI, as were the number of apoptotic spermatozoa stained with TUNEL. Conclusion: Results showed that SCI disturbs sperm parameters, nuclear maturity, and DNA integrity of spermatozoa. Therefore, the production of spermatozoa with less condensed chromatin and more apoptotic rate increases after cord injury and this may be one possible cause of infertility following SCI.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sperm chromatin condensation, DNA integrity, and apoptosis in men with spinal cord injury

Talebi

Khalili

Vahidi

et al. 2013

The Journal of Spinal Cord Medicine

View full text Add to dashboard Cite

show abstract

“…Count ( epithelium have been reported by Rebrelo et al (1996), while decrease in sperm motility and increase in number of malformed sperm cells were also observed on seminal plasma due to such toxic effects of copper (Salsabili et al, 2009). In agreement with the previous studies, our study clearly demonstrated that overload of copper causes adverse effects on epididymal spermatozoa and testis in the mice.…”

Section: Groupssupporting

confidence: 94%

Effects ofCuminum cyminumL. essential oil on some epididymal sperm parameters and histopathology of testes following experimentally induced copper poisoning in mice

et al. 2015

View full text Add to dashboard Cite

Copper overload can cause sperm cell damage by inducing oxidative stress. On the other hand, cumin has a good antioxidant potential. Therefore, the aim of this study was to evaluate the effects of cumin on sperm quality and testicular tissue following experimentally induced copper poisoning in mice. Forty-eight mature male mice were divided into four equal groups as follows: group Cu which received 0.1 ml copper sulphate at dose of 100 mg kg(-1) , group Cc which received Cuminum cyminum at dose of 1 mg kg(-1) , treatment group which received copper sulphate (100 mg kg(-1) ) and treated with Cuminum cyminum (1 mg kg(-1) ), and control group which received the same volume of normal saline. Six mice in each group were sacrificed at week 4 and week 6. The results showed that sperm concentration, motility and viability in group Cu were significantly decreased at weeks 4 and 6, and severe degenerative changes were observed in testicular tissues in comparison with the control group. In treatment group, significant improvement in the sperm count, motility and viability, and normal architecture in most seminiferous tubules with organised epithelium was observed compared to the group Cu. The sperm quality parameters in the treatment group approached those of the control group.

show abstract

“…As it is shown, spermatozoa with poor DNA integrity may lead to fertilization failure, delayed embryo development, and early pregnancy loss ( 54 , 55 ). Evenson and Wixon reported that pregnancy rate significantly decreased with semen samples containing more than 30% spermatozoa with fragmented DNA ( 56 ).…”

Section: Introductionmentioning

confidence: 99%

The etiologies of sperm DNA abnormalities in male infertility: An assessment and review

Pourmasumi¹,

Sabeti²,

Rahiminia³

et al. 2017

IJRM

View full text Add to dashboard Cite

The sperm DNA damage may occur in testis, genital ducts, and also after ejaculation. Mechanisms altering chromatin remodeling are abortive apoptosis and oxidative stress resulting from reactive oxygen species. Three classifications of intratesticular, post-testicular, and external factors have been correlated with increased levels of human sperm DNA damage which can affect the potential of fertility. Lifestyle, environment, medical, and iatrogenic factors might be considered to cause dysmetabolism to make distracting interactions and endocrine disrupting compounds. As a result, these may induce chromatin/DNA alteration in germ cells, which may be transmitted across generations with phenotypic consequences. Alcohol consumption may not increase the rate of sperm residual histones and protamine deficiency; however, it causes an increase in the percentage of spermatozoa with DNA fragmentation and apoptosis. In a medical problem as spinal cord injury, poor semen parameters and sperm DNA damage were reported. Infection induces reactive oxygen species production, decreases the total antioxidant capacity and sperm DNA fragmentation or antigen production that lead to sperm dysfunctions and DNA fragmentation. While reactive oxygen species generation increases with age, oxidative stress may be responsible for the age-dependent sperm DNA damage. The exposing of reproductive organs in older men to oxidative stress for a long time may produce more DNA-damaged spermatozoa than youngers. Examining the sperm chromatin quality in testicular cancer and Hodgkin’s lymphoma patients prior to chemotherapy demonstrated the high incidence of DNA damage and low compaction in spermatozoa at the time of the diagnosis. In chemotherapy cycle with genotoxic agents in cancer patients, an increase in sperm DNA damage was shown after treatment. In overall, those factors occurring during the prenatal or the adult life alter the distribution of proteins associated with sperm chromatin induce changes in germ cells which can be detected in infertile patients.

show abstract

Concentration of blood and seminal plasma elements and their relationships with semen parameters in men with spinal cord injury

Cited by 21 publications

References 19 publications

Sperm chromatin condensation, DNA integrity, and apoptosis in men with spinal cord injury

Sperm chromatin condensation, DNA integrity, and apoptosis in men with spinal cord injury

Effects ofCuminum cyminumL. essential oil on some epididymal sperm parameters and histopathology of testes following experimentally induced copper poisoning in mice

The etiologies of sperm DNA abnormalities in male infertility: An assessment and review

Contact Info

Product

Resources

About