Concentration of biologically active compounds extracted from Sideritis ssp. L. by nanofiltration

Tylkowski, Bartosz; Tsibranska, I.; Kochanov, Ruslan; Peev, G.; Giamberini, Marta

doi:10.1016/j.fbp.2010.11.003

Cited by 64 publications

(28 citation statements)

References 22 publications

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“…171 The concentration of biologically active compounds by the SRNF process has also been studied. 172 Because the SRNF process requires little energy and is athermal (thereby avoiding damage the chemical structure of active molecules), many studies have focused on using SRNF in pharmaceutical fields.…”

Section: Pharmaceutical Applicationsmentioning

confidence: 99%

“…Sheth et al 165 claimed that precompacting commercial MPF-50 or MPF-60 with used solvents at operational pressures and temperatures is necessary to remove erythromycin because precompaction increased the rejection of erythromycin by SRNF membranes, which reduced the loss of erythromycin and increased the purification efficiency. Shi et al 166 fabricated a type of PI membrane to concentrate spiramycin 220 (n-alkanes in toluene) [168][169][170][171][173][174][175]180,182,184,[190][191][192]195,197 Starmem TM 228 280 (n-alkanes in toluene) 169,179,184,196 Starmem TM 240 400 (n-alkanes in toluene) [171][172][173][174][175]180,182,184,185,189,196,197 Puramem TM extracts and recover the used solvent (butyl acetate). They indicated that the permeability of the spiramycin solution was significantly affected by the operating conditions, although the rejection of spiramycin (higher than 99%) was not influenced.…”

Section: Pharmaceutical Applicationsmentioning

confidence: 99%

“…124,[161][162][163][164] Most recently, the separation and purification of active molecules in organic medium by NF membranes (called SRNF membranes) has attracted significant attention because unlike conventional distillation, this process is athermal. The SRNF membranes can potentially be used in the pharmaceutical manufacturing industry, [165][166][167][168][169][170][171][172][198][199][200] catalysis recovery processes, [173][174][175][176][177][178][179][180][181][182][183]196,197 the concentration of biologically active compounds in food technology, 192 the recovery of ion liquids, [184][185][186] the purification of fuels and solvents, 188,189 refining technologies, 187 and many other fields. 205 All of these fields have a common feature: the cost and the energy consumption to prepare or recover active molecules are very high, which makes the application of SRNF economically attractive.…”

Section: Advanced Applications Of Srnf Membranesmentioning

confidence: 99%

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Recent Advances in Polymeric Solvent‐Resistant Nanofiltration Membranes

et al. 2014

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When considering energy consumption and environmental issues, solvent-resistant nanofiltration (SRNF) based on polymeric materials emerges as a process for substituting conventional separation processes of organic solutions, such as distillation, which consume high amounts of energy. Because SRNF does not involve phase transition, this process can potentially decrease the energy consumption and solvent waste and increase the yield of active components. Such improvements could significantly benefit a number of fields, such as pharmaceutical manufacturing and catalysis recovery, among others. Therefore, SRNF has gained a lot of attention since the recent introduction of solvent-stable polymeric materials in the manufacture of nanofiltration membranes. The membrane materials and the membrane structures depending on the fabrication methods determine the separation performance of polymeric SRNF membranes. Therefore, this article gives a comprehensive overview of the current state-of-art technologies of generating membrane materials and corresponding fabrication methods for SRNF membranes made from polymeric materials expected to provide the most benefit. The transport mechanisms and the corresponding models of SRNF membranes in organic media are also reviewed to better understand the mass transfer process. Various SRNF applications, such as in pharmaceutical and catalyst, among others, are also discussed. Finally, the difficulties and future research directions to overcome the challenges faced by SRNF processes are proposed. C

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Section: Pharmaceutical Applicationsmentioning

confidence: 99%

Section: Pharmaceutical Applicationsmentioning

confidence: 99%

Section: Advanced Applications Of Srnf Membranesmentioning

confidence: 99%

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Recent Advances in Polymeric Solvent‐Resistant Nanofiltration Membranes

et al. 2014

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“…NF of organic solutions, which is also known as solvent resistant NF (SRNF), is applied to separate compounds dissolved in solvents with molecular weight (MW) ranging from 200 to 1400 Da, with simultaneous passing of the organic solvent through the membrane. Industrially, SRNF-based technologies allow effective recovery of solvent in lube oil dewaxing processes [6], degumming of vegetable oil [7], reuse of extraction solvent in food industries [8] and purification of pharmaceutically active ingredients [9]. Table 1 shows several established areas of SRNF applications together with their separation efficiencies.…”

Section: Introductionmentioning

confidence: 99%

Influence of polymer concentration in casting solution and solvent-solute-membrane interactions on performance of polyphenylsulfone (PPSU) nanofiltration membrane in alcohol solvents

Sani

Lau

Ismail

2014

Journal of Polymer Engineering

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In this work, the performances of solvent resistant nanofiltration (SRNF) membranes made of polyphenylsulfone (PPSU) were evaluated with respect to alcohol solvent (methanol, ethanol and isopropanol) flux and dye rejection. The experimental results showed that the solvent flux decreased while dye rejection increased with increasing polymer concentration in the casting solution from 17 wt% to 25 wt%. Apart from molecular size of the solute and viscosity of the solvent, the affinity between the solvent and the membrane was also confirmed to play a significant role in affecting the transport rate of the solvent through the membrane. With respect to the effect of solvent properties and solute size on the dye rejection of solvent-dye mixtures, it was found that the variation of dye rejection is governed by solvent-solute-membrane interactions. The solvent-solute interaction causes the same solute to have different solute size in each tested solvents, whereas the solvent-membrane interaction would result in a change in membrane pore size, leading to different separation efficiency. However, it must pointed out that solvent-membrane interaction is more pronounced compared to solvent-solute interaction, as the dye rejection of ethanol solution is reportedly higher than that of methanol, even though the size of solute in ethanol is smaller compared to its size in methanol.

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“…as a preliminary stage of the target product concentration . OSN has been studied and applied in many downstream extraction processes, such as vegetable‐oil dewaxing, degumming, deacidification, and decolorization, nutritional enrichment of oils, high‐added value, and bioactive compound concentration . The first large‐scale application of this technology was in solvent recovery from the dewaxing operation in lubes processing (MAX‐DEWAX TM process, developed by Exxon Mobil Corporation) .…”

Section: Introductionmentioning

confidence: 99%

Application of organic solvent nanofiltration for microalgae extract concentration

Lopresto

Darvishmanesh

Ehsanzadeh

et al. 2016

Biofuels Bioprod Bioref

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Microalgae lipids hold significant potential as a biofuel feedstock. The high‐lipid content found in some species of microalgae is a major superiority over other sources. Furthermore, they have a high production rate record per area and survive in areas not already used for food production. This study considered the use of an integrated membrane process for oil extraction from microalgae. Different technologies were explored for laboratory‐scale microalgae oil extraction, including the use of organic solvents, but they would require a further purification. Organic solvent nanofiltration (ONF) was employed for separation of solvent from oil: the solvent passed through the dense polymeric membrane while oil molecules were rejected by the membrane. Since different organic solvents were used in literature for oil extraction from microalgae, this study examined different oil‐solvent mixtures and their separation by commercial hydrophobic and hydrophilic membranes. Experimental results showed that the new generation of ONF membranes has a superior performance compared to the previously used membranes. Based on rejection tests of oil in ethanol, isopropanol, and acetone, the applicability of the new commercial membranes for solvent recovery was demonstrated. Hydrophobic membranes had superior performances when oil was extracted using n‐hexane as the solvent, whereas methanol miscella had the highest flux and rejection in hydrophilic membranes. Finally, the conventional and hybrid approach were simulated in Aspen. The approach including nanofiltration saves around 97% of the energy requirements for the separation. In terms of economic costs, the conventional alternative is slightly more convenient in a short‐term situation. © 2016 Society of Chemical Industry and John Wiley & Sons, Ltd

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Concentration of biologically active compounds extracted from Sideritis ssp. L. by nanofiltration

Cited by 64 publications

References 22 publications

Recent Advances in Polymeric Solvent‐Resistant Nanofiltration Membranes

Recent Advances in Polymeric Solvent‐Resistant Nanofiltration Membranes

Influence of polymer concentration in casting solution and solvent-solute-membrane interactions on performance of polyphenylsulfone (PPSU) nanofiltration membrane in alcohol solvents

Application of organic solvent nanofiltration for microalgae extract concentration

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