Concentration gradients of monoamine metabolites in human cerebrospinal fluid.

Sjöström, Rolf; Ekstedt, Jan; Änggård, Erik

doi:10.1136/jnnp.38.7.666

Cited by 105 publications

(34 citation statements)

References 12 publications

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“…As for HVA and 5-HIAA (e.g. [22,23,25,30,31]), the increases in concentra-tions of t-MH and t-MIAA were also linear ( Fig. 1) with sequential volumes of CSF.…”

Section: Discussionmentioning

confidence: 79%

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Rostral-caudal concentration gradients of histamine metabolites in human cerebrospinal fluid

et al. 1989

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The metabolites of histamine, tele-methylhistamine (t-MH) and tele-methylimidazoleacetic acid (t-MIAA), have a large concentration gradient between cisternal and lumbar CSF in the rhesus monkey. The possibility of a t-MH and/or t-MIAA gradient in man was studied in sequential samples of CSF withdrawn from the lumbar space from a healthy male. The mean levels of t-MH and t-MIAA in the 14-16 ml segment of CSF from 6 male volunteers was also measured. pros-Methylimidazoleacetic acid (p-MIAA), an endogenous isomer of t-MIAA that is not derived from histamine, was also measured. Levels of t-MH, t-MIAA and p-MIAA were measured by gas chromatography-mass spectrometry. With increasing volumes of CSF removed, t-MH and t-MIAA levels increased linearly (p less than 0.01) when plotted against the midpoints of each volume segment. Levels of t-MH and t-MIAA from the volunteers showed little variation; the means of the levels were within 15% of the respective regression lines of the points from the single subject. In contrast, p-MIAA levels showed no gradient (p greater than 0.6) in serially removed CSF; the individual levels in CSF from the volunteers on unrestricted diets varied widely, suggestive of a dietary influence on p-MIAA levels in the CNS. The concentration gradient of histamine metabolites in CSF confirms the rostral-caudal gradient observed in monkey and argues against plasma or spinal cord as major sources of these metabolites.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…As for HVA and 5-HIAA (e.g. [22,23,25,30,31]), the increases in concentra-tions of t-MH and t-MIAA were also linear ( Fig. 1) with sequential volumes of CSF.…”

Section: Discussionmentioning

confidence: 79%

“…[22][23][24], 5-hydroxyindoleacetic acid (5-HIAA) (e.g. [25]), norepinephrine, 3-methoxy-4-hydroxyphenylglycol (MHPG) (e.g. [26]) and 7-aminobutyric acid (e.g.…”

Section: Discussionmentioning

confidence: 99%

Rostral-caudal concentration gradients of histamine metabolites in human cerebrospinal fluid

et al. 1989

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“…Wode-Helgodt and Sedwall (1978) found the same relationship between height and the levels of HVA as we did. Previously, HVA and 5 HIAA levels had been found to exhibit rostrocaudal gradients; higher concentrations were measured in the cisternal rather than in the lumbar CSF (Sjostrom et al, 1975) and in serial lumbar punctures the HVA levels increased by the last puncture (Ben Menachem et al, 1989). However, in an animal study, 5 HIAA was suggested to derive mainly from the spinal cord (Bulat, 1977).…”

Section: Discussionmentioning

confidence: 93%

Neurotransmitter markers in the cerebrospinal fluid of normal subjects effects of aging and other confounding factors

Hartikainen

Soininen

Reinikainen

et al. 1991

J. Neural Transmission

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We have investigated neurotransmitter-related markers of the cerebrospinal fluid (CSF) in a carefully screened series of normally aging subjects in standardized conditions in order to find out the influence of age and other confounding factors on CSF measures. The levels of 3-methoxy-4-hydroxyglycol (MHPG) and the activity of acetylcholinesterase (AChE) also increased with age, while homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5 HIAA) and immunoreactivities of somatostatin (SLI), beta-endorphin (BLI) and adrenocorticotropic hormone (ACTH) were unrelated to age. The gender of subjects had no significant effect on the levels of neurotransmitter markers, while seasonal changes, as well as height and weight of the subjects seemed to cause some variations in the levels of HVA, dopamine-beta-hydroxylase (DBH) and ACTH. The study underscores the importance of standardized conditions and matched patient groups in the CSF studies.

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“…The absence of a negative correlation between height and CSF 5-HlAA in MDMA subjects is notewor thy in one other respect. The inverse relation between height and CSF 5-HIAA is thought to arise, at least in part, from a concentration gradient of 5-HIAA along the craniospinal axis (Sjostrom et al 1975;Weir et al 1973;Garelis et al 197 4). Its absence in MDMA users raises the possibility that MDMA perturbs those proces ses that normally contribute to the CSF 5-HlAA grad ient.…”

Section: Discussionmentioning

confidence: 99%

Serotonin Neurotoxicity after (±)3,4-Methylenedioxymethamphetamine (MDMA; “Ecstasy”): A Controlled Study in Humans

McCann¹,

Ridenour

Shaham

et al. 1994

Neuropsychopharmacol

305

174

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(±)3,4-Methylenedioxymethamphetamine (MDMA; "Ecstasy"), an increasingly popular recreational drug, is known to damage brain serotonin 5-hydroxytryptamine (5-HT) neurons in experimental animals. Whether MDMA is neurotoxic in humans has not been established. Thirty MDMA users and 28 controls were admitted to a controlled inpatient setting for measurement of biologic and behavioral indexes of central 5-HT function. Outcome measures obtained after at least 2 weeks of drug abstinence included concentrations of monoamine metabolites in cerebrospinal fluid (CSF), prolactin responses to L-tryptophan, nociceptive responses to ischemic pain, and personality characteristics in which 5-HT has been implicated (i.e., impulsivity and aggression). Subjects with a history of MDMA exposure had lower levels of CSF 5-hydroxyindoleacetic acid (the

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Concentration gradients of monoamine metabolites in human cerebrospinal fluid.

Cited by 105 publications

References 12 publications

Rostral-caudal concentration gradients of histamine metabolites in human cerebrospinal fluid

Rostral-caudal concentration gradients of histamine metabolites in human cerebrospinal fluid

Neurotransmitter markers in the cerebrospinal fluid of normal subjects effects of aging and other confounding factors

Serotonin Neurotoxicity after (±)3,4-Methylenedioxymethamphetamine (MDMA; “Ecstasy”): A Controlled Study in Humans

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