Concentration-dependent change in hypothalamic neuronal transcriptome by the dietary fatty acids: oleic and palmitic acids

Lactobacillus rhamnosus Sex-Specifically Attenuates Depressive-like Behavior and Mitigates Metabolic Consequences in Obesity

“…Moreover, elevated central CCK signaling can suppress dopaminergic signaling in addition to TH activity and impact emotional behavior ( 19 , 43 , 44 ). Lastly, on a molecular level, palmitate has been shown to induce CCK signaling in hypothalamic neurons, connecting the exposure to a lard-based HFD to elevated CCK in the brain ( 45 ). Moreover, a decrease in TH and low levels of dopamine due to increased turnover have previously been associated with alterations in emotional behavior ( 5 , 10 ), and we confirmed this observation, showing that TH mRNA levels were decreased in HFD conditions (RNA sequencing and quantitative polymerase chain reaction) as a sign of altered dopaminergic signaling.…”