Concentration-dependent behaviors of bone marrow derived mesenchymal stem cells and infectious bacteria toward magnesium oxide nanoparticles

Wetteland, Cheyann Lee; Nguyen, Nhu-Y Thi; Liu, Huinan

doi:10.1016/j.actbio.2016.02.032

Cited by 70 publications

(92 citation statements)

References 42 publications

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“…In addition, MNMS nanosheets released the ROS, which is highly stabilized in basic solution . However, these ROS are the main factors in the bactericidal action of MNMSs nanosheets, causing cytotoxic effect of MNMSs against pathogenic microbes …”

Section: Resultsmentioning

confidence: 99%

Hexagonal Mg(OH)₂ Nanosheets as Antibacterial Agent for Treating Contaminated Water Sources

et al. 2017

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Many water sources are contaminated by Gram‐positive and Gram‐negative pathogenic bacteria. In this work, low‐cost antibacterial mesoporous nano‐hexagonal Mg(OH)2 sheets (MNMSs) with uniform sizes of 250–450 nm were fabricated. Their structural features enabled the sheets to be a powerful antibacterial agent with high surface reactivity owing to well‐scattered pore windows that provide the sheets with a large surface area. Results revealed that the minimum inhibitory concentrations for Staphylococcus aureus and Escherichia coli bacteria were 0.45 and 0.50 mg ml−1, respectively. MNMSs inhibited >97% of very high viable bacterial count 90×104 cfu ml−1 in a one‐step process through 12 hours. Complete inhibition of bacterial growth occurred while maintaining the MNMSs layer composition, indicating reusability. The MNMSs antibacterial agent surface areas were 21.83 and 20.09 m2 g−1 for before and after usage, respectively, while the pore volume has no significant differences for MNMSs before and after usage represented by 0.043 and 0.044 cm3 g−1, respectively. The treated bacterial cells were completely inactivated through the interaction of nanosheets with bacteria, leading to extensively damaged cell membranes and decomposition of internal cellular components. Therefore, the MNMSs can be used to treat biological pollution in water.

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Section: Resultsmentioning

confidence: 99%

Hexagonal Mg(OH)₂ Nanosheets as Antibacterial Agent for Treating Contaminated Water Sources

et al. 2017

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“…Recent studies into Mg-containing nanomaterials include MgONPs for orthopedic implant coating and fabrication of MgO-containing nanocomposites as scaffolds for bone tissue regeneration. Wetteland et al 143 report possible guidelines for MgONP-coated biomaterial design. The study showed a significant increase in bone marrowderived mesenchymal stem cells and antibacterial activity when exposed to 200 µg/mL of MgONPs.…”

mentioning

confidence: 99%

Antibacterial properties and toxicity from metallic nanomaterials

Vimbela¹,

Ngo²,

Fraze³

et al. 2017

IJN

497

334

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The era of antibiotic resistance is a cause of increasing concern as bacteria continue to develop adaptive countermeasures against current antibiotics at an alarming rate. In recent years, studies have reported nanoparticles as a promising alternative to antibacterial reagents because of their exhibited antibacterial activity in several biomedical applications, including drug and gene delivery, tissue engineering, and imaging. Moreover, nanomaterial research has led to reports of a possible relationship between the morphological characteristics of a nanomaterial and the magnitude of its delivered toxicity. However, conventional synthesis of nanoparticles requires harsh chemicals and costly energy consumption. Additionally, the exact relationship between toxicity and morphology of nanomaterials has not been well established. Here, we review the recent advancements in synthesis techniques for silver, gold, copper, titanium, zinc oxide, and magnesium oxide nanomaterials and composites, with a focus on the toxicity exhibited by nanomaterials of multidimensions. This article highlights the benefits of selecting each material or metal-based composite for certain applications while also addressing possible setbacks and the toxic effects of the nanomaterials on the environment.

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“…), and thus increased its direct contact with BMSCs. The nMgO nanoparticles were previously reported to increase BMSC adhesion and proliferation at a low concentration of 200 µg/mL and induced the death of BMSCs at the concentrations >500 µg/mL . This indicated possible cytotoxicity of nMgO at higher concentrations, especially when nMgO was in direct contact with cells.…”

Section: Discussionmentioning

confidence: 92%

“…The nMgO nanoparticles were previously reported to increase BMSC adhesion and proliferation at a low concentration of 200 μg/mL and induced the death of BMSCs at the concentrations >500 μg/mL. 15 This indicated possible cytotoxicity of nMgO at higher concentrations, especially when nMgO was in direct contact with cells. The nMgO/PLGA_A increased cell density at the first 24 h of culture likely because agglomeration reduced direct contact of nMgO with BMSCs and the concentration of nMgO on the top surface was at a low level beneficial to cells.…”

Section: Optical Properties Of the Nanocomposites With Dispersed Versmentioning

confidence: 93%

“…14 Moreover, MgO in the nanoparticle form (that is, nMgO) showed attractive antibacterial properties for potentially reducing infections associated with dowelling medical implants and devices. 15 Hydroxyapatite (HA) is a naturally occurring ceramic material present in human bone and is known to enhance bone regeneration because of its osteoconductivity and osteoinductivity. 16,17 HA in its nanophase (that is, nHA) improved osteoblast cell adhesion and long-term functions in vitro and in vivo.…”

Section: Introductionmentioning

confidence: 99%

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Optical and biological properties of polymer‐based nanocomposites with improved dispersion of ceramic nanoparticles

Wetteland

Liu

2018

J Biomedical Materials Res

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This article reports a new process for creating polymer-based nanocomposites with enhanced dispersion of ceramic nanoparticles without using any surfactants, and the resulted changes in their optical and biological properties. Specifically, dispersion of two different ceramic nanoparticles, that is, hydroxyapatite (nHA) and magnesium oxide (nMgO) nanoparticles, in a model biodegradable polymer, namely poly(lactic-co-glycolic acid) (PLGA), was studied. High-power sonication was integrated with dual asymmetric centrifugal (DAC) mixing to improve dispersion of nanoparticles during solvent casting. The polymer/solvent ratio was optimized to improve nanoparticle dispersion in the multistep processing, including enhancing the efficacy of sonication and DAC mixing and reducing nanoparticle sedimentation during solvent-casting. Microstructural characterization confirmed that this new process improved nanoparticle dispersion in nMgO/PLGA and nHA/PLGA nanocomposites. Improved nanoparticle dispersion increased the optical transparency visually and optical transmission quantitatively for both nHA/PLGA and nMgO/PLGA nanocomposites. Improved dispersion of nanoparticles improved the adhesion of bone marrow derived mesenchymal stem cells (BMSCs) on nHA/PLGA but decreased BMSC viability on nMgO/PLGA. This difference is likely because the chemistry of nHA and nMgO had different effects on BMSCs. This study provided a new process for enhancing dispersion of ceramic nanoparticles in a polymer matrix and revealed the effects of dispersion on optical properties and cell responses, which are valuable for engineering optimal ceramic/polymer nanocomposites for different biomedical applications. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2692-2707, 2018.

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Concentration-dependent behaviors of bone marrow derived mesenchymal stem cells and infectious bacteria toward magnesium oxide nanoparticles

Cited by 70 publications

References 42 publications

Hexagonal Mg(OH)₂ Nanosheets as Antibacterial Agent for Treating Contaminated Water Sources

Hexagonal Mg(OH)₂ Nanosheets as Antibacterial Agent for Treating Contaminated Water Sources

Antibacterial properties and toxicity from metallic nanomaterials

Optical and biological properties of polymer‐based nanocomposites with improved dispersion of ceramic nanoparticles

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Concentration-dependent behaviors of bone marrow derived mesenchymal stem cells and infectious bacteria toward magnesium oxide nanoparticles

Cited by 70 publications

References 42 publications

Hexagonal Mg(OH)2 Nanosheets as Antibacterial Agent for Treating Contaminated Water Sources

Hexagonal Mg(OH)2 Nanosheets as Antibacterial Agent for Treating Contaminated Water Sources

Antibacterial properties and toxicity from metallic nanomaterials

Optical and biological properties of polymer‐based nanocomposites with improved dispersion of ceramic nanoparticles

Contact Info

Product

Resources

About

Hexagonal Mg(OH)₂ Nanosheets as Antibacterial Agent for Treating Contaminated Water Sources

Hexagonal Mg(OH)₂ Nanosheets as Antibacterial Agent for Treating Contaminated Water Sources