We consider theoretical aspects of the intrinsic limit to low-temperature mobility μ in semiconducting structures with single heterojunctions, taking into account the scattering of the two-dimensional (2D) carriers by piezoelectric acoustic phonons. We find that the reduction of the concentration of 2D carriers to n s = 4.2 × 10 11 cm −2 in the region of small-angle scattering will result in a mobility as high as 110 × 10 6 cm 2 (V s) −1 at T = 1.6 K. Since the maximum mobility depends on the concentration of carriers as n 5/2 s , it grows up to 320 × 10 6 cm 2 (V s) −1 at n s = 8.2 × 10 11 cm −2 and approximately the same temperature T = 1.5 K. Detailed numerical results are presented as a function of 2D carrier density and temperature and serve as a guide to experimentalists who wish to achieve peak carriers' mobility.