Concentration and Fractionation of Polyphenols by Membrane Operations

Tylkowski, Bartosz; Nowak, Martyna; Tsibranska, I.; Trojanowska, Anna; Marciniak, Łukasz; Valls, Ricard Garcia; Gumı́, Tània; Giamberini, Marta; Jastrząb, Renata

doi:10.2174/1381612822666161021124358

Cited by 12 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The concentration and selective fractionation of bioactive compounds from aqueous and alcoholic processing streams of agro-food production by pressure-driven membrane processes, including ultrafiltration (UF) and nanofiltration (NF), have been extensively studied in the last years [14,15,16]. These processes offer several advantages when compared with conventional separation methodologies.…”

Section: Introductionmentioning

confidence: 99%

A Membrane-Based Process for the Recovery of Glycyrrhizin and Phenolic Compounds from Licorice Wastewaters

et al. 2019

View full text Add to dashboard Cite

In this work, the use of polymeric ultrafiltration and nanofiltration membranes was investigated in order to recover glycyrrhizin and phenolic compounds from licorice wastewaters. Filtration experiments were performed on a laboratory scale using four polyamide thin-film composite membranes (GK, GH, GE, and DK, from GE Osmonics) with different molecular weight cut-offs (from 150 to 3500 Da). The permeate flux and retention values of glycyrrhizin, the total polyphenols, the caffeic acid, the total carbohydrate, and the total antioxidant activity as a function of the transmembrane pressure (TMP) and weight reduction factor (WRF) were evaluated. In selected operating conditions, the membrane productivity decreased in the order of GK > DK > GH > GE, with a similar trend to that of water permeability. Glycyrrhizin was totally rejected by selected membranes, independently of TMP and WRF. For the other antioxidant compounds, the retention values increased by increasing both of the parameters. According to the experimental results, a combination of membranes in a sequential design was proposed as a viable approach to produce concentrated fractions enriched in bioactive compounds and purified water from licorice wastewater.

show abstract

Section: Introductionmentioning

confidence: 99%

A Membrane-Based Process for the Recovery of Glycyrrhizin and Phenolic Compounds from Licorice Wastewaters

et al. 2019

View full text Add to dashboard Cite

show abstract

“…It has been reported that plant materials could contain up to 10.000 naturally occurring compounds belonging to the category of "phenolics" with different molecular weights (Mw) 35 . As Tsibranska and co-authors 16 reported, polyphenols with Mw higher than the membrane cut-off are retained on the membrane surface in dead-end filtration methods such as filtration sterilization, resulting in a loss of material. Indeed, the deep inspection of the filter surface with optical microscope after the extract sterilization put into evidence some dark spots (see Fig.…”

Section: Resultsmentioning

confidence: 99%

“…functional groups [13][14][15] . They are classified into the following groups: phenolic acids, flavonoids, lignans, curcuminoids, stilbenes, and tannins 16 . Recently, multiple studies have documented anticancer activity in phenolic acids and flavonoids, which has been attributed to their potent antioxidant and anti-inflammatory properties as well as their capabilities to modulate molecular targets and signaling pathways that have been associated with cell survival, decreased cell proliferation, increased apoptosis, suppression of angiogenesis, detoxification enzymes, immune responses, and many others 7,[17][18][19][20][21][22] .…”

mentioning

confidence: 99%

Stability and anti-proliferative properties of biologically active compounds extracted from Cistus L. after sterilization treatments

Ammendola

Haponska

Balik

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

The growing interest of oncologists in natural compounds such as polyphenols and flavonoids is encouraging the development of innovative and efficient carriers for the delivery of those drugs. This study examines carboxymethyl chitosan-based microcapsules created by spray drying as a method for delivering biologically active compounds isolated from the Cistus herb. Effects of sterilization and encapsulation on the polyphenol and flavonoid content of Cistus extract were investigated to optimize the production process. Furthermore, in vitro studies were carried out to examine the anticancer properties of sterilized polyphenols and flavonoids on glioblastoma cells isolated from oncological patients. Acquired results show high anticancer potential towards glioblastoma as well as low cytotoxicity towards non-cancer cell lines by the substances in question. Steam sterilization is shown to affect the content of biologically active compounds the least. We demonstrate that the investigated form of drug encapsulation is both efficient and potentially possible to scale up from the viewpoint of the pharmaceutical industry. According to apress statement launched by the International Agency for Research on Cancer from the World Health Organization (WHO), in 2018the global cancer burdenaffected 18.1 million new cases and 9.6 million of people passed away. Ten in 50 men and one in 60 women worldwide suffer from cancer during their life, and ten in 80 men and eleven in 110 women posse awaydue to thisillness. Moreover, cancer is a most frequent causeof children death. Worldwide, every year, approximately 300.000 of children are diagnosed by oncologists with a cancer disease 1,2. Furthermore, according to the published statistic data, the total number of people who are alive within 5 years of a cancer diagnosis, called the 5-year prevalence, is arround 43.8 million 3. As stated in the WHO report,the frequent types of cancer in men are cancer of lung, prostate, colorectal, stomach and liver, while in case on women, the most common type of cancer are: breast, colorectal, lung, cervix and thyroid cancer. The uncontrollable growth of tumor cells is the most fundamental aspect of cancer 4. Even if available therapies such as surgery, immunotherapy, chemotherapy, targeted therapy, hormone therapy and radiation therapy play a significant role in cancer treatment, drug resistance and toxicity remain main problems and challenges to cure cancer patients 5. Oncologists have called for basic investigationsand new upstream technologieswhich insustainably, efficiently and safely way will meet the current and future patients' needs 6,7. Additionally, during the last years the "integrative" oncology society has demanded advancesfrom scientists on the development of natural medicals 8,9. Indeed, the anticancer effects of biologically active compounds, such as natural polyphenols synthesized by fruits, vegetables, teas, apples, cocoa and other plants, have become a hot topic in many laboratories 10-12 .

show abstract

“…Continuous processes , and membrane-based separations can significantly improve the sustainability and economics of chemical manufacturing . The field of organic solvent nanofiltration (OSN) has significantly evolved over the past decade, and robust membranes are available for “in-line” solvent recycling, which can drastically reduce solvent consumption. − OSN has recently been proposed for the fractionation of lignin, flavonoids, and polyphenol compounds. However, the obtained fractions contained a mixture of structurally similar compounds with similar molecular weights.…”

Section: Introductionmentioning

confidence: 99%

Process Intensification via Continuous and Simultaneous Isolation of Antioxidants: An Upcycling Approach for Olive Leaf Waste

Voros

Drioli

Fonte³

et al. 2019

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

Isolation of individual pharmaceutical-grade bioactive compounds from complex plant extracts is still a sustainability challenge. Process intensification improves manufacturing design to achieve significant benefits in process efficiency and operation, product quality, and waste management. A process optimization and intensification methodology for the simultaneous isolation of biophenols from agricultural waste using imprinted materials and nanofiltration membranes is reported herein. First, temperature-swing molecular imprinting technology was used to selectively extract individual biophenols from olive leaf extracts.Second, solvent-resistant nanofiltration was used to in line concentrate the product and waste streams as well as recover the solvent. The predictive mathematical models for the adsorption dynamics and the membrane separation resulted in a significant reduction in the carbon footprint, E factor and economic sustainability. The process was designed for easy operation with multi-way valves to aid safety and reduce operating costs. The presented process intensification methodology can be generally exploited for waste upcycling through sustainable isolation of multiple high-value products from complex mixtures.

show abstract

Concentration and Fractionation of Polyphenols by Membrane Operations

Cited by 12 publications

References 0 publications

A Membrane-Based Process for the Recovery of Glycyrrhizin and Phenolic Compounds from Licorice Wastewaters

A Membrane-Based Process for the Recovery of Glycyrrhizin and Phenolic Compounds from Licorice Wastewaters

Stability and anti-proliferative properties of biologically active compounds extracted from Cistus L. after sterilization treatments

Process Intensification via Continuous and Simultaneous Isolation of Antioxidants: An Upcycling Approach for Olive Leaf Waste

Contact Info

Product

Resources

About