Concentrated small extracellular vesicles from menstrual blood-derived stromal cells improve intrauterine adhesion, a pre-clinical study in a rat model

Zhang, Siwen; Chang, Qiyuan; Li, Pingping; Tong, Xiaoyu; Feng, Yi; Hao, Xinyao; Zhang, Xudong; Yuan, Zhengwei; Tan, Jichun

doi:10.1039/d0nr08942g

Cited by 24 publications

(23 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results allow us to understand the complexity of the molecular networks in uterine stem cell-derived extracellular vesicles and their potential effects on target cells. The application of these vesicles and their contents has also been observed in other studies, such as one where menstrual stem cell-derived small extracellular vesicles are able to alleviate intrauterine adhesion-associated uterine damage, recovering proper endometrial morphology, reversing fibrosis, and promoting gland regeneration and angiogenesis [ 132 ], probably through inhibiting TGFβ1/SMAD3 signaling, along with promoting SMAD1/5/8 and ERK1/2 phosphorylation, as well as upregulating BMP7 [ 132 ]. In fact, these vesicles are more effective in treating intrauterine adhesion compared to cell therapies, as their effects are more localized within the endometrium [ 132 ].…”

Section: The Effects Of the Utero-cardiac Axis For Developing Uterine...mentioning

confidence: 83%

“…The application of these vesicles and their contents has also been observed in other studies, such as one where menstrual stem cell-derived small extracellular vesicles are able to alleviate intrauterine adhesion-associated uterine damage, recovering proper endometrial morphology, reversing fibrosis, and promoting gland regeneration and angiogenesis [ 132 ], probably through inhibiting TGFβ1/SMAD3 signaling, along with promoting SMAD1/5/8 and ERK1/2 phosphorylation, as well as upregulating BMP7 [ 132 ]. In fact, these vesicles are more effective in treating intrauterine adhesion compared to cell therapies, as their effects are more localized within the endometrium [ 132 ]. Extracellular vesicles may also exert their effects through miRNAs, such as exosomal Let-7, which is able to decrease pulmonary fibrosis via alleviating mitochondrial DNA damage [ 133 ], as well as miR-21, which serves as the basis behind the greater cardioprotective capabilities and angiogenesis increases associated with endometrial stem cells, through its activation of PTEN/Akt pathway [ 90 ].…”

Section: The Effects Of the Utero-cardiac Axis For Developing Uterine...mentioning

confidence: 83%

See 1 more Smart Citation

Uterus: A Unique Stem Cell Reservoir Able to Support Cardiac Repair via Crosstalk among Uterus, Heart, and Bone Marrow

Hatta

Yao

2022

Cells

View full text Add to dashboard Cite

Clinical evidence suggests that the prevalence of cardiac disease is lower in premenopausal women compared to postmenopausal women and men. Although multiple factors contribute to this difference, uterine stem cells may be a major factor, as a high abundance of these cells are present in the uterus. Uterine-derived stem cells have been reported in several studies as being able to contribute to cardiac neovascularization after injury. However, our studies uniquely show the presence of an “utero-cardiac axis”, in which uterine stem cells are able to home to cardiac tissue to promote tissue repair. Additionally, we raise the possibility of a triangular relationship among the bone marrow, uterus, and heart. In this review, we discuss the exchange of stem cells across different organs, focusing on the relationship that exists between the heart, uterus, and bone marrow. We present increasing evidence for the existence of an utero-cardiac axis, in which the uterus serves as a reservoir for cardiac reparative stem cells, similar to the bone marrow. These cells, in turn, are able to migrate to the heart in response to injury to promote healing.

show abstract

Section: The Effects Of the Utero-cardiac Axis For Developing Uterine...mentioning

confidence: 83%

Section: The Effects Of the Utero-cardiac Axis For Developing Uterine...mentioning

confidence: 83%

Uterus: A Unique Stem Cell Reservoir Able to Support Cardiac Repair via Crosstalk among Uterus, Heart, and Bone Marrow

Hatta

Yao

2022

Cells

View full text Add to dashboard Cite

show abstract

“…Therefore, subsequent IUA management is considered necessary when IUA occurs. Thus far, there have been many publications addressing the topic of the management of IUA [ 23 , 24 , 26 , 27 , 28 , 29 , 30 , 35 , 40 , 43 , 57 , 58 , 59 , 62 , 64 , 131 , 132 , 133 , 134 , 135 , 136 , 138 , 139 , 140 , 141 , 142 , 155 , 164 , 165 , 166 , 167 , 168 ].…”

Section: Future Vision Of Iua Managementmentioning

confidence: 99%

Focus on the Primary Prevention of Intrauterine Adhesions: Current Concept and Vision

Lee

Liu

Chen

et al. 2021

IJMS

View full text Add to dashboard Cite

Intrauterine adhesion (IUA), and its severe form Asherman syndrome (Asherman’s syndrome), is a mysterious disease, often accompanied with severe clinical problems contributing to a significant impairment of reproductive function, such as menstrual disturbance (amenorrhea), infertility or recurrent pregnancy loss. Among these, its correlated infertility may be one of the most challenging problems. Although there are many etiologies for the development of IUA, uterine instrumentation is the main cause of IUA. Additionally, more complicated intrauterine surgeries can be performed by advanced technology, further increasing the risk of IUA. Strategies attempting to minimize the risk and reducing its severity are urgently needed. The current review will expand the level of our knowledge required to face the troublesome disease of IUA. It is separated into six sections, addressing the introduction of the normal cyclic endometrial repairing process and its abruption causing the formation of IUA; the etiology and prevalence of IUA; the diagnosis of IUA; the classification of IUA; the pathophysiology of IUA; and the primary prevention of IUA, including (1) delicate surgical techniques, such as the use of surgical instruments, energy systems, and pre-hysteroscopic management, (2) barrier methods, such as gels, intrauterine devices, intrauterine balloons, as well as membrane structures containing hyaluronate–carboxymethylcellulose or polyethylene oxide–sodium carboxymethylcellulose as anti-adhesive barrier.

show abstract

“…[ 1 , 2 ] To prevent and treat IUAs, a number of strategies have been developed, such as transcervical resection of adhesions, [ 3 ] uterine cavity balloons, [ 4 ] intrauterine scaffolds, [ 5 , 6 , 7 , 8 , 9 , 10 , 11 ] and other methods. [ 12 , 13 , 14 , 15 , 16 , 17 ] Although with a certain therapeutic effect, these approaches are still faced with problems including high postoperative recurrence rates, easy dislocation, biological inertia, and so on. In contrast, biomedical patches have proven their superior antiadhesive abilities in medical fields, [ 18 , 19 , 20 , 21 , 22 ] some of which have even been imparted with anisotropic structures to improve their performances.…”

Section: Introductionmentioning

confidence: 99%

Arrowhead Composite Microneedle Patches with Anisotropic Surface Adhesion for Preventing Intrauterine Adhesions

et al. 2022

View full text Add to dashboard Cite

Biomedical patches are considered as a promising strategy to help tissue repair and regeneration, prevent tissue adhesion, and reduce neighboring friction. Here, novel arrowhead composite microneedle patches (MNPs) are presented with anisotropic surface adhesion and growth factor encapsulation using a heterogeneous template replication approach for endometrium repair and intrauterine adhesions (IUAs) prevention. The arrowhead structures bring about interlocking between the microneedle (MN) tips and tissues, allowing these MNPs to steadily adhere to the tissues. Besides, benefitting from the cytoadhesive needle‐tip material and the antiadhesive base material, these MNPs possess anisotropic surface adhesion and can facilitate cell adhesion on one surface to repair damaged tissues while restrain tissue contact on the other to prevent adverse adhesion. In the meanwhile, the encapsulated growth factor can be delivered through the MNs to the deep tissue, further accelerating tissue repair. Additionally, as the bases are soft and their patterns are highly tunable, the MNPs can change their shapes flexibly to adjust to the irregular morphology of uteri. It is demonstrated that these MNPs show good performances in treating injured endometrium and preventing IUAs of a rat model, indicating their great potential in versatile postoperative adhesion prevention and other clinical applications.

show abstract

Concentrated small extracellular vesicles from menstrual blood-derived stromal cells improve intrauterine adhesion, a pre-clinical study in a rat model

Abstract: MenSCs-sEVs safely and effectively enhanced endometrial restoration, suggesting a promising non-cellular therapy for endometrial regeneration and a key role in MenSC-mediated IUA treatment.

Cited by 24 publications

References 49 publications

Uterus: A Unique Stem Cell Reservoir Able to Support Cardiac Repair via Crosstalk among Uterus, Heart, and Bone Marrow

Uterus: A Unique Stem Cell Reservoir Able to Support Cardiac Repair via Crosstalk among Uterus, Heart, and Bone Marrow

Focus on the Primary Prevention of Intrauterine Adhesions: Current Concept and Vision

Arrowhead Composite Microneedle Patches with Anisotropic Surface Adhesion for Preventing Intrauterine Adhesions

Contact Info

Product

Resources

About