Concentrated oat β-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial

Abstract

Background: Soluble fibers lower serum lipids, but are difficult to incorporate into products acceptable to consumers. We investigated the physiological effects of a concentrated oat β-glucan on cardiovascular disease (CVD) endpoints in human subjects. We also compared the fermentability of concentrated oat β-glucan with inulin and guar gum in a model intestinal fermentation system.

Intake of brown rice lees reduces waist circumference and improves metabolic parameters in type 2 diabetes

“…Furthermore, rice bran contains predominantly insoluble fiber. It is well established that soluble dietary fiber has cholesterol-lowering effects, and the mechanism of this effect is well understood [29,30]. In contrast, the effect of insoluble dietary fiber on lipid profiles is unclear.…”

Effects of yeast-derived β-glucans on blood cholesterol and macrophage functionality

“…Therefore, it was important to learn if these glucans also possess a cholesterol-lowering activity. The cholesterol-lowering effects of glucans are wellestablished in numerous models, including humans (Fadel et al, 1987;Queenan et al, 2007;Reyna-Villasmil et al, 2007). These effects are usually described as the result of fiber intake and subsequent decreased absorption of bile acids (Malkki, 2001), albeit without any substantiating proof.…”

“…Due to the high consumption of oats or oat bran, attention has focused mainly on the relationship between oat-derived glucan and cholesterol levels. These glucans were shown to reduce serum cholesterol in both hypercholesterolemic animals (Fadel et al, 1987;Kahlon et al, 1993;Delaney et al, 2003) and humans (Queenan et al, 2007). However, some studies found no such effects (Keogh et al, 2003).…”

Polymorphisms in LEP and NPY genes modify the response to soluble fibre Plantago ovata husk intake on cardiovascular risk biomarkers

“…Plantago ovata husk (Po-husk) is a source of natural, concentrated, soluble fibre. Several studies have shown that the consumption of soluble fibre such as Po-husk reduces the risk of developing cardiovascular disease (CVD) through reduction in total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels (Brown et al 1999;Theuwissen and Mensink 2008;Anderson et al 2009;Queenan et al 2007). Moreover, it has been shown that soluble fibre is more effective in lowering blood cholesterol and LDL-C concentrations than insoluble fibre (Brown et al 1999;Vuksan et al 2011;Fernandez 2001;Jenkins et al 2000;Solà et al 2007).…”