Concentrated grape juice (G8000™) reduces immunoexpression of iNOS, TNF-alpha, COX-2 and DNA damage on 2,4,6-trinitrobenzene sulfonic acid-induced-colitis

Marchi, Patrícia Gelli Feres de; Paiotti, Ana Paula Ribeiro; Neto, Ricardo Artigiani; Oshima, Celina Tizuko Fujiyama; Ribeiro, Daniel Araki

doi:10.1016/j.etap.2014.02.006

Cited by 32 publications

(17 citation statements)

References 29 publications

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“…22 Administration of 1% GJ at 7 d after TNBS-administration reduced macroscopic and histological damage scores and reduced colonic cyclooxygen-ase-2 (COX-2), TNF-α and iNOS proteins. 22 However, treatment with 1% or 2% GJ at 24 h after TNBS-induction did not prevent macroscopic or histological markers of inflammation. 22 Food & Function Review 3.1.2 Blueberry, bilberry, raspberry and hawthorn berry.…”

Section: Anthocyaninsmentioning

confidence: 96%

A review of the efficacy of dietary polyphenols in experimental models of inflammatory bowel diseases

2015

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Crohn's disease and ulcerative colitis presently have no cure and are treated with anti-inflammatory drugs or monoclonal antibodies targeting pro-inflammatory cytokines. A variety of rodent models have been used to model chronic and acute colitis. Dietary polyphenols in foods and botanicals are of considerable interest for prevention and treatment of colitis. Many dietary polyphenols have been utilized for prevention of colitis in rodent models. Berries, green tea polyphenols, curcumin, and stilbenes have been the most extensively tested polyphenols in rodent models of colitis. The majority of polyphenols tested have inhibited colitis in rodents, but increasing doses of EGCG and green tea, isoflavones, flaxseed, and α-mangostin have exacerbated colitis. Few studies have examined combination of polyphenols or other bioactives for inhibition of colitis. Translating polyphenol doses used in rodent models of colitis to human equivalent doses reveals that supplemental doses are most likely required to inhibit colitis from a single polyphenol treatment. The ability to translate polyphenol treatments in rodent models is likely to be limited by species differences in xenobiotic metabolism and microbiota. Given these limitations, data from polyphenols in rodent models suggests merit for pursuing additional clinical studies for prevention of colitis.

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Section: Anthocyaninsmentioning

confidence: 96%

A review of the efficacy of dietary polyphenols in experimental models of inflammatory bowel diseases

2015

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“…Anti-inflammatory effects of grape juice have been reported in an in vivo study (TABLE 1), which demonstrated oral administration of the grape juice at 1 and 2% doses can decrease proinflammatory cytokines including inducible nitric oxide synthase, TNF-a, COX-2, peripheral blood genotoxicity and morphological signs of cell damage in chronic colitis induced by 2,4,6-trinitrobenzenesulfonic acid [145].…”

Section: Grape Anthocyaninsmentioning

confidence: 97%

“…Oral: 1 and 2% # Morphological signs of cell damage, # TNF-a, iNOS and COX-2, # peripheral blood genotoxicity [145] Bilberry anthocyanins Fruit -Human study Oral: 840 mg/day # Total Mayo score, # Riley index # fecal calprotectin levels [116] Bilberry anthocyanins Fruit DSS-induced UC BALB/c mice Oral: 20% dried bilberry 1 and 10% anthocyanin extract # Secretion of IFN-g, TNF-a and IL-6, # intestinal inflammation, # histological scores, # colon shortening, # leukocytes infiltration, # apoptotic epithelial cells [115] Bilberry anthocyanins…”

Section: Male Wistar Ratsmentioning

confidence: 99%

Dietary anthocyanins as a complementary medicinal approach for management of inflammatory bowel disease

Sodagari

Farzaei

Bahramsoltani

et al. 2015

Expert Review of Gastroenterology & Hepatology

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Inflammatory bowel disease (IBD) is thought to result from a chronic or relapsing activation of the immune system in the GI tract. A growing body of evidence confirms the health benefits of dietary anthocyanins as plant-derived natural agents. The aim of this review is to provide an overview of several natural products rich in anthocyanins used worldwide for the treatment of IBD. Anthocyanins possess both protective and therapeutic functions in the management of IBD by alleviating oxidative stress processes, cytoprotective functions, downregulation of inflammatory cytokines and suppressing cellular signaling pathways of inflammatory processes. In conclusion, the consumption of anthocyanin-rich natural formulations must be promoted on the basis of their possible function in the prevention and treatment of gastrointestinal inflammatory disorders.

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“…We have demonstrated that G8000 was able to exert important human health outcomes using animal models under different protocols and paradigms (Aguiar Jr et al, 2011;de Jesus et al, 2014;Marchi et al, 2014;Moura et al, 2014;Paiotti et al, 2013;Pires et al, 2013).…”

Section: Introductionmentioning

confidence: 98%

Novel natural food colourant G8000 benefits LDL- and HDL-cholesterol in humans

Peres

Gollucke

Soares

et al. 2015

International Journal of Food Sciences and Nutrition

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The aim of this study was to investigate the phenolic composition of a natural food colourant (G8000™) as well as its effects on plasma markers after 28-day consumption by healthy individuals at a dietary dose (70 g). Parameters of total cholesterol and its fractions, triglycerides and plasma enzymes biomarkers of muscle injury were measured. Major compounds identified in G8000™ by ESI-MS showed the presence of anthocyanins, organic acids, phenolic acids as well as monosaccharides. HDL levels significantly increased from 43 ± 10.2 mg/dL to 95 ± 16.9 mg/dL. LDL levels significantly decreased from 110 ± 40.9 mg/dL to 69 ± 39 mg/dL (p < 0.001). No significant statistical differences (p > 0.05) were observed for total cholesterol, triglycerides and VLDL. After the intake, plasma enzyme CK-MB decreased from 20 ± 12.1 U/L to 10 ± 1.9 U/L while LDH levels increased from 275 ± 124.4 U/L to 317 ± 114.7 U/L (p < 0.005). No significant differences were observed for CK levels. Taken together, dietary intake of natural colourant G8000™ was able to exert beneficial effects on atherosclerosis biomarkers.

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Concentrated grape juice (G8000™) reduces immunoexpression of iNOS, TNF-alpha, COX-2 and DNA damage on 2,4,6-trinitrobenzene sulfonic acid-induced-colitis

Cited by 32 publications

References 29 publications

A review of the efficacy of dietary polyphenols in experimental models of inflammatory bowel diseases

A review of the efficacy of dietary polyphenols in experimental models of inflammatory bowel diseases

Dietary anthocyanins as a complementary medicinal approach for management of inflammatory bowel disease

Novel natural food colourant G8000 benefits LDL- and HDL-cholesterol in humans

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