Concentrated Bone Marrow Aspirate Improves Full-Thickness Cartilage Repair Compared with Microfracture in the Equine Model

Fortier, Lisa A.; Potter, Hollis G.; Rickey, Ellen J.; Schnabel, Lauren V.; Foo, Li Foong; Chong, Leroy R; Stokol, Tracy; Cheetham, Jon; Nixon, Alan J.

doi:10.2106/jbjs.i.01284

Cited by 363 publications

(326 citation statements)

References 44 publications

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“…In the equine model, improved cartilage healing has been demonstrated both histologically and radiologically in groups receiving CBMA at the time of BMS, compared with groups receiving BMS alone [94]. In addition, similar results were reported in a goat model when using BMS combination with CBMA and HA [95].…”

Section: Concentrated Bone Marrow Aspiratesupporting

confidence: 64%

Osteochondral lesions of the talus in the athlete: up to date review

Shimozono

Yasui

Ross

et al. 2017

Curr Rev Musculoskelet Med

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Purpose of review Osteochondral lesions of the talus (OLT) are common injuries in athletes. The purpose of this study is to comprehensively review the clinical results and return to sport capacity in athletes following treatment for OLT. Recent findings Reparative procedures, such as bone marrow stimulation, and replacement procedures, such as autologous osteochondral transplantation, provide good clinical outcomes in short-and mid-term follow-up in the athlete. Recently, biological augmentation and scaffold-based therapies have been shown to improve clinical and radiological outcomes in OLT in both the general population and athletes. Summary Most studies are of a low level of evidence. Studies analyzing the return to sport capability in athletes are further lacking. High-level evidence and well-designed clinical trials are required to establish the most effective treatment protocol.

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Section: Concentrated Bone Marrow Aspiratesupporting

confidence: 64%

Osteochondral lesions of the talus in the athlete: up to date review

Shimozono

Yasui

Ross

et al. 2017

Curr Rev Musculoskelet Med

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“…A perfuração ou abrasão do osso subcondral induz a migração de células e dos fatores de crescimento provenientes da vasculatura subcondral e da medula óssea para o local da lesão; além disso, facilita a adesão do coágulo de fibrina (Vinatier et al, 2009;Fortier et al, 2010). Sendo assim, a perfuração do osso subcondral neste estudo iria, de forma significativa, interferir na avaliação dos efeitos do tratamento proposto, sendo, portanto, invariavelmente evitada.…”

Section: Resultsunclassified

“…A presença de fatores de crescimento em abundância no PRP também estimula a produção de proteoglicanos pelos condrócitos e acelera a reparação tecidual (Gaissmaier et al, 2008), o que esclarece a melhora no aspecto histoquímico dos cortes corados com azul de toluidina no G1. A melhora morfológica nos animais do G1 foi resultante dos efeitos mitogênico, quimiotáxico e proliferativo do PRP, já citados por Fortier et al (2010) e Milano et al (2010. Figura 1.…”

Section: Resultsunclassified

“…Consiste, basicamente, em centrifugações do sangue total. Diversos fatores de crescimento são capazes de acelerar e modular os processos de reparação, atuando na proliferação celular, diferenciação e formação de matriz extracelular (Carmona et al, 2009;Fortier et al, 2010). Acredita-se que o PRP seja, ainda, capaz de bloquear a expressão de fatores nucleares e a ação de moléculas pró-inflamatórias, como as interleucinas, atuando de forma anti-inflamatória e analgésica (ElSharkawy et al, 2007).…”

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Plasma rico em plaquetas no tratamento de lesões condrais articulares induzidas experimentalmente em equinos: avaliação clínica, macroscópica, histológica e histoquímica

Yamada

Carvalho

Oliveira

et al. 2012

Arq. Bras. Med. Vet. Zootec.

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Plasma rico em plaquetas no tratamento de lesões condrais articulares induzidas experimentalmente em equinos: avaliação clínica, macroscópica, histológica e histoquímica [Platelet-rich plasma RESUMOEstudou-se a eficácia do plasma rico em plaquetas (PRP) no tratamento de lesões condrais articulares, experimentalmente induzidas em equinos. Para isso, foi induzida uma lesão condral, na tróclea medial femoral dos dois membros pélvicos de quatro animais. Após 30 dias da indução, as oito articulações foram divididas em dois grupos. Os animais do grupo 1 receberam o tratamento intralesional e intra-articular com PRP, e os do grupo 2 foram tratados apenas com solução fisiológica. As avaliações clínicas, constituídas de exames de claudicação e análises do líquido sinovial, foram realizadas antes da indução da lesão  tempo zero , quinzenalmente, até 120 dias e aos 150 dias. Avaliações macroscópicas, histológicas e histoquímicas foram realizadas no tempo zero e aos 150 dias. Os equinos do grupo 1 apresentaram melhora do grau de claudicação em relação aos do grupo 2. Os exames macroscópicos, histológicos e histoquímicos revelaram melhor tecido de reparação igualmente no grupo 1. Concluiu-se que a administração de PRP apresentou efeitos benéficos no tratamento de lesões condrais experimentais de equinos.Palavras-chave: equino, articulação, artroscopia, plasma rico em plaquetas ABSTRACTThe use of platelet-rich plasma (PRP)

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“…Lysis of red blood cells can be performed to enhance the concentration of MSC in porcine bone marrow, which yields a cell population capable of chondrogenic differentiation (Peterbauer-Scherb et al, 2010). In an equine model, application of concentrated bone marrow aspirates in combination with microfracture clearly improved cartilage repair in a onestep procedure (Fortier et al, 2010).…”

Section: Referencementioning

confidence: 99%

State of the art and future perspectives of articular cartilage regeneration: a focus on adipose-derived stem cells and platelet-derived products

Hildner

Albrecht

Gabriel

et al. 2011

J Tissue Eng Regen Med

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Trauma, malposition and age-related degeneration of articular cartilage often result in severe lesions that do not heal spontaneously. Many efforts over the last centuries have been undertaken to support cartilage healing, with approaches ranging from symptomatic treatment to structural cartilage regeneration. Microfracture and matrix-associated autologous chondrocyte transplantation (MACT) can be regarded as one of the most effective techniques available today to treat traumatic cartilage defects. Research is focused on the development of new biomaterials, which are intended to provide optimized physical and biochemical conditions for cell proliferation and cartilage synthesis. New attempts have also been undertaken to replace chondrocytes with cells that are more easily available and cause less donor site morbidity, e.g. adipose derived stem cells (ASC). The number of in vitro studies on adult stem cells has rapidly increased during the last decade, indicating that many variables have yet to be optimized to direct stem cells towards the desired lineage. The present review gives an overview of the difficulties of cartilage repair and current cartilage repair techniques. Moreover, it reviews new fields of cartilage tissue engineering, including stem cells, co-cultures and platelet-rich plasma (PRP).

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Concentrated Bone Marrow Aspirate Improves Full-Thickness Cartilage Repair Compared with Microfracture in the Equine Model

Abstract: Delivery of bone marrow concentrate to cartilage defects has the clinical potential to improve cartilage healing, providing a simple, cost-effective, arthroscopically applicable, and clinically effective approach for cartilage repair.

Cited by 363 publications

References 44 publications

Osteochondral lesions of the talus in the athlete: up to date review

Osteochondral lesions of the talus in the athlete: up to date review

Plasma rico em plaquetas no tratamento de lesões condrais articulares induzidas experimentalmente em equinos: avaliação clínica, macroscópica, histológica e histoquímica

State of the art and future perspectives of articular cartilage regeneration: a focus on adipose-derived stem cells and platelet-derived products

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