Concentraciones elevadas de homocisteína en el síndrome de ovario poliquístico

Calle, María de la; Gallardo, Teresa Escrich; Diestro, María Dolores; Hernánz, Ángel; Pérez, E Rodríguez; Fernández‐Miranda, Consuelo

doi:10.1157/13109117

Cited by 7 publications

(2 citation statements)

References 10 publications

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“…It is well established that folate supplementation can increase global DNA methylation and affect gene expression [ 48 , 49 ]. Multiple studies have identified increased homocysteine, an indicator of folate deficiency, in women with PCOS [ 50 , 51 ], and supplementation with folate is useful to increase the beneficial effect of metformin on the vascular endothelium [ 52 ]. Considering the role of global DNA hypomethylation in the GCs of PCOS in our study, we speculate that it is advisable to utilize folate to prevent the global loss of methylation for PCOS women, especially for those undergoing IVF procedure.…”

Section: Discussionmentioning

confidence: 99%

Aberrant expression and DNA methylation of lipid metabolism genes in PCOS: a new insight into its pathogenesis

et al. 2018

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BackgroundPolycystic ovary syndrome (PCOS), whose etiology remains uncertain, is a highly heterogenous and genetically complex endocrine disorder. The aim of this study was to identify differentially expressed genes (DEGs) in granulosa cells (GCs) from PCOS patients and make epigenetic insights into the pathogenesis of PCOS.ResultsIncluded in this study were 110 women with PCOS and 119 women with normal ovulatory cycles undergoing in vitro fertilization acting as the control group. RNA-seq identified 92 DEGs unique to PCOS GCs in comparison with the control group. Bioinformatic analysis indicated that synthesis of lipids and steroids was activated in PCOS GCs. 5-Methylcytosine analysis demonstrated that there was an approximate 25% reduction in global DNA methylation of GCs in PCOS women (4.44 ± 0.65%) compared with the controls (6.07 ± 0.72%; P < 0.05). Using MassArray EpiTYPER quantitative DNA methylation analysis, we also found hypomethylation of several gene promoters related to lipid and steroid synthesis, which might result in the aberrant expression of these genes.ConclusionsOur results suggest that hypomethylated genes related to the synthesis of lipid and steroid may dysregulate expression of these genes and promote synthesis of steroid hormones including androgen, which could partially explain mechanisms of hyperandrogenism in PCOS.Electronic supplementary materialThe online version of this article (10.1186/s13148-018-0442-y) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Aberrant expression and DNA methylation of lipid metabolism genes in PCOS: a new insight into its pathogenesis

et al. 2018

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“…[26,27] The current study assesses the VB12 status with the most robust approach using Fedosov's wellness quotient (4cB12) that incorporated four VB12D markers, i.e., sB12, holotranscobalamine (HTC), HCY, or methylmalonic acid (MMA) which, if taken solitary, may underestimate the actual burden of VB12D. [28,27] Besides assessing clinical, biochemical, hormonal correlation with VB12 status, the study analyses various IMs among reproductive age women practicing vegetarian and nonvegetarian diets.…”

Section: Introductionmentioning

confidence: 99%

Impact of Prevalent Dietary Pattern on Serum Vitamin B12 Status and Its Association With Inflammation Among Reproductive Age Women

Ganie,

Bashir,

Sehar

et al. 2024

Molecular Nutrition Food Res

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ScopeAssociation between vitamin B12 deficiency (VB12D) and dietary patterns being well documented has bearing on obstetrics and neonatal outcomes. However, relationship between VB12D and serum inflammatory markers (IMs), particularly in vegetarian diet and Polycystic ovary syndrome (PCOS), remains elusive. This cross‐sectional study assesses VB12D and IMs among reproductive age women consuming different diets.Methods and resultsNonvegetarian (PCOS, n = 104; healthy, n = 148) and vegetarian women (PCOS n = 112; healthy, n = 186) are for evaluated clinical, biochemical, hormonal assessment, inflammatory, and four vitamin B 12 (VB12) markers. VB12D is defined by Fedosov's wellness quotient (4cB12). Using 4cB12, prevalence of VB12D is discerned in 54.4% (PCOS: 72.1%; healthy 36.5%) and 93.4% (PCOS: 95.9%; healthy: 91.9%) among nonvegetarians and vegetarians, respectively. Vegetarian PCOS women depict lowest median (interquartile range [IQR]) of serum B12 76.2(72.6) pg mL−1, holotranscobalamine (HTC) 37.9(11.3) and highest homocysteine (HCY) 40.32(6.0) µmol L−1, methylmalonic acid (MMA) 352.26(156.7) nmol L−1 with highest Homeostatic Model Assessment for Insulin Resistance (HOMA‐IR) and IMs (Monocyte chemoattractant protein 1 (MCP‐1), High sensitivity C‐reactive protein (hs‐CRP), Tumour Necrosis Factor alpha (TNF‐α) and Interleukin 6 (IL‐6)). Significant correlation of serum hs‐CRP, TNF‐α, and IL‐6 with VB12 markers is observed.ConclusionThe VB12D is rampant among reproductive age women that gets exacerbated by PCOS or vegetarian diet. It is directly correlated with magnitude of proinflammatory markers. The results carry substantial implications for public health policies aimed at improving preconception maternal VB12 status for better future pregnancy and offspring outcomes.

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Síndrome de ovario poliquístico y riesgo cardiovascular

Sesmilo

González‐Sastre

2007

Medicina Clínica

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Concentraciones elevadas de homocisteína en el síndrome de ovario poliquístico

Cited by 7 publications

References 10 publications

Aberrant expression and DNA methylation of lipid metabolism genes in PCOS: a new insight into its pathogenesis

Aberrant expression and DNA methylation of lipid metabolism genes in PCOS: a new insight into its pathogenesis

Impact of Prevalent Dietary Pattern on Serum Vitamin B12 Status and Its Association With Inflammation Among Reproductive Age Women

Síndrome de ovario poliquístico y riesgo cardiovascular

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