Concealed for a Long Time on the Marches of Empires: Hepatitis B Virus Genotype I
Agnès Marchio,
Philavanh Sitbounlang,
Eric Deharo
et al.
Abstract:Genotype I, the penultimate HBV genotype to date, was granted the status of a bona fide genotype only in the XXIst century after some hesitations. The reason for these hesitations was that genotype I is a complex recombinant virus formed with segments from three original genotypes, A, C, and G. It was estimated that genotype I is responsible for only an infinitesimal fraction (<1.0%) of the chronic HBV infection burden worldwide. Furthermore, most probably due to its recent discovery and rarity, the natural… Show more
“…This genetic variability has important clinical implications. The virus has been classified into different 10 genotypes and numerous sub-genotypes, with some of them less studied than others [5].…”
Hepatitis B is a “silent epidemic” that is fifty to a hundred (50–100) times more infectious than HIV and is a potentially life-threatening liver infection [...]
“…This genetic variability has important clinical implications. The virus has been classified into different 10 genotypes and numerous sub-genotypes, with some of them less studied than others [5].…”
Hepatitis B is a “silent epidemic” that is fifty to a hundred (50–100) times more infectious than HIV and is a potentially life-threatening liver infection [...]
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