Conarubins A–D: Four Monoterpene–Chalcone Conjugates from Conamomum rubidum and Their Anti-inflammatory and Cytotoxic Activities

Abstract

Four novel compounds, conarubins A–D (1–4), were isolated from the whole plants of Conamomum rubidum collected in Vietnam. Their structures were elucidated by extensive spectroscopic analyses and by quantum chemical calculations of NMR and ECD. Compounds 1 and 2 were the first examples of monoterpene–monoterpene–chalcone conjugates in nature, whereas compound 4 was an unprecedented monoterpene-substituted chalcone containing a 3,4,5-trioxygenated cyclohexa-2,5-diene-1-one ring. The anti-inflammatory and cytotoxic activities of all isolates were investigated.

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“…Four monoterpene–chalcone conjugates have been isolated from Conamomum rubidium . 11 Conarubins A 14 and B 15 are the first examples of chalcone meroterpenoids with two monoterpene units and conarubin D 16 has an unusual 3,4,5-trioxygenated cyclohexa-2,5-dien-1-one ring.…”