“…However, we speculate that T lymphocytes are essential for the initiation of this process, but additional experiments are required to determine whether they or other lymphoid cells, e.g., B cells or monocyte- on August 1, 2020 by guest http://iai.asm.org/ Downloaded from macrophages, or both, produce active factors. Furthermore, we speculate that soluble active factors elevate PMN to an enhanced metabolic state in a manner described for several activating compounds (5,9,21,27), namely, interaction with membrane receptors. As shown in this study and our previous report (8) on in vivo-activated PMN, enhanced killing by activated PMN appears linked with severalfold greater production of toxic products from oxidative metabolism after appropriate stimulation.…”