COMT Met (158) modulates facial emotion recognition in bipolar I disorder mood episodes

Soeiro-de-Souza, Márcio Gerhardt; Bio, Danielle Soares; David, Denise Petresco; Santos, Domingos Rodrigues dos; Kerr, Daniel Shikanai; Gattaz, Wagner F.; Machado‐Vieira, Rodrigo; Moreno, R.A.

doi:10.1016/j.jad.2011.11.021

Cited by 26 publications

(29 citation statements)

References 45 publications

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“…This study, unlike those reported by other authors [56,61], did not identify a main effect for the COMT Val158Met polymorphism or its interaction with 5-HTTLPR on the recognition of mimicked expression by patients and healthy subjects, despite the use of the appropriate tests. The test used presents high demands on the conscious cognitive processing of mimicked expressions.…”

Section: Resultscontrasting

confidence: 99%

“…Contradictions in existing results can partly be explained in terms of the specific infl uence of COMT on the perception of emotions in different cohorts. For example, studies of patients with bipolar disorder and healthy subjects reported by Soeiro-de-Souza et al [56] showed that the effect of the Met allele on the identifi cation of mimicked expressions depended on both the presence of disease and its phase (depression/mania).…”

Section: Resultsmentioning

confidence: 99%

“…In particular, it has been shown to be associated with responses to stress [13] and modulation of activity in the amygdala and some of the prefrontal areas of the brain in response to emotional stimuli [15,16,30,35,54,63], including in schizophrenia [37]; it is also associated with negative shifts in attention [25,63]. The Val158Met polymorphism has been shown to make a contribution to variation in emotion-recognizing ability in healthy people and patients with affective disorders [56,61]. Additive and epistatic effects of Val158Met COMT and 5-HTTLPR on anxiety [48] and cerebral correlates of the processing of emotional stimuli have also been demonstrated [55,57].…”

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confidence: 99%

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Effects of the 5-HTTLPR Polymorphism of the Serotonin Transporter Gene on the Recognition of Mimicked Emotional Expressions in Schizophrenia

Алфимова

Golimbet

Коровайцева

et al. 2015

Neurosci Behav Physi

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Existing data point to a link, within the general population, between polymorphic variants of the serotonin transporter gene (5-HTTLPR SLC6A4) and catechol-O-methyltransferase on the one hand and the processing of information related to emotional facial expressions on the other. Schizophrenia patients are characterized by a defi cit in the recognition of mimicked emotional expressions, which has adverse effects on their social adaptation. With the aim of seeking the molecular mechanisms of this defi cit, we have assessed the main and epistatic effects of these polymorphisms on the recognition of emotions among schizophrenia patients (n = 299) and healthy control subjects (n = 232). The 5-HTTLPR polymorphism showed a signifi cant relationship with the recognition of emotions by patients. Homozygotes for the long allele identifi ed facial emotions signifi cantly better than carriers of the short allele (F = 8.00, p = 0.005). Although the recognition of emotions in the patients group correlated with negative symptoms, verbal learning, and trait anxiety, these signs did not have signifi cant modifying infl uences on the association detected here. COMT was found to have no effect on the recognition of emotions either in normal subjects or in schizophrenia patients.

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Section: Resultscontrasting

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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confidence: 99%

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Effects of the 5-HTTLPR Polymorphism of the Serotonin Transporter Gene on the Recognition of Mimicked Emotional Expressions in Schizophrenia

Алфимова

Golimbet

Коровайцева

et al. 2015

Neurosci Behav Physi

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“…The impact of the CACNA1C A allele on brain volume in BD type I has previously been evaluated in BD; two studies reported negative results, 32, 57 whereas two reported increased volume associated with the A allele. 1, 6 Perrier et al 1 reported that A carriers had increased GM density in the right amygdala and right hypothalamus in a sample of 41 BD euthymic type I patients compared to 50 HCs.…”

Section: Discussionmentioning

confidence: 99%

The CACNA1C risk allele rs1006737 is associated with age-related prefrontal cortical thinning in bipolar I disorder

et al. 2017

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Calcium channels control the inflow of calcium ions into cells and are involved in diverse cellular functions. The CACNA1C gene polymorphism rs1006737 A allele has been strongly associated with increased risk for bipolar disorder (BD) and with modulation of brain morphology. The medial prefrontal cortex (mPFC) has been widely associated with mood regulation in BD, but the role of this CACNA1C polymorphism in mPFC morphology and brain aging has yet to be elucidated. One hundred seventeen euthymic BD type I subjects were genotyped for CACNA1C rs1006737 and underwent 3 T three-dimensional structural magnetic resonance imaging scans to determine cortical thickness of mPFC components (superior frontal cortex (sFC), medial orbitofrontal cortex (mOFC), caudal anterior cingulate cortex (cACC) and rostral anterior cingulate cortex (rACC)). Carriers of the CACNA1C allele A exhibited greater left mOFC thickness compared to non-carriers. Moreover, CACNA1C A carriers showed age-related cortical thinning of the left cACC, whereas among A non-carriers there was not an effect of age on left cACC cortical thinning. In the sFC, mOFC and rACC (left or right), a negative correlation was observed between age and cortical thickness, regardless of CACNA1C rs1006737 A status. Further studies investigating the direct link between cortical thickness, calcium channel function, apoptosis mechanism and their underlying relationship with aging-associated cognitive decline in BD are warranted.

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“…One study demonstrated a relationship between dopamine catabolism and altruism (Reuter, Frenzel, Walter, Markett, & Montag, 2011), another between dopamine-relevant genes and social facilitation (Walter, Markett, Montag, & Reuter, 2011). Another series of studies has investigated the relationship between dopamine and recognition and neural responses to emotional faces in adults (Blasi et al, 2009; Lelli-Chiesa et al, 2011; Soeiro-de-Souza et al, 2012; Weiss et al, 2007). Only one study has investigated mentalizing, and showed that variation of the dopamine receptor D4 gene was associated with preschoolers' understanding that other people's actions are caused by internal mental states (Lackner, Sabbagh, Hallinan, Liu, & Holden, 2012).…”

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confidence: 99%

Preliminary investigation of the influence of dopamine regulating genes on social working memory

Dumontheil

Jensen

Wood

et al. 2014

Social Neuroscience

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Working memory (WM) refers to mental processes that enable temporary retention and manipulation of information, including information about other people (“social working memory”). Previous studies have demonstrated that nonsocial WM is supported by dopamine neurotransmission. Here, we investigated in 131 healthy adults whether dopamine is similarly involved in social WM by testing whether social and nonsocial WM are influenced by genetic variants in three genes coding for molecules regulating the availability of dopamine in the brain: catechol-O-methyltransferase (COMT), dopamine active transporter (DAT), and monoamine-oxidase A (MAOA). An advantage for the Met allele of COMT was observed in the two standard WM tasks and in the social WM task. However, the influence of COMT on social WM performance was not accounted for by its influence on either standard WM paradigms. There was no main effect of DAT1 or MAOA, but a significant COMT × DAT1 interaction on social WM performance. This study provides novel preliminary evidence of effects of genetic variants of the dopamine neurotransmitter system on social cognition. The results further suggest that the effects observed on standard WM do not explain the genetic effects on effortful social cognition.

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COMT Met (158) modulates facial emotion recognition in bipolar I disorder mood episodes

Cited by 26 publications

References 45 publications

Effects of the 5-HTTLPR Polymorphism of the Serotonin Transporter Gene on the Recognition of Mimicked Emotional Expressions in Schizophrenia

Effects of the 5-HTTLPR Polymorphism of the Serotonin Transporter Gene on the Recognition of Mimicked Emotional Expressions in Schizophrenia

The CACNA1C risk allele rs1006737 is associated with age-related prefrontal cortical thinning in bipolar I disorder

Preliminary investigation of the influence of dopamine regulating genes on social working memory

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